Effect of preparation technique on in vitro release mechanism of huperzine A microspheres

Yaoxue Xuebao

Volumn 41, Issue 7, 2006, Pages 589-594

  Fu, Xu Dong ^a,b   Gao, Yong Liang ^a   Ping, Qi Neng ^c  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b WUHAN GENERAL HOSPITAL OF GUANGZHOU COMMAND   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Drug distribution; Huperzine A; In vitro release rate; O O emulsion solvent evaporation method; Poly(lactic co glycolic acid) microspheres

Indexed keywords

CHOLINESTERASE INHIBITOR; HUPERZINE A; LACTIC ACID; MICROSPHERE; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYMER; SESQUITERPENE;

ARTICLE; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG FORMULATION; METHODOLOGY; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY;

CHOLINESTERASE INHIBITORS; DRUG COMPOUNDING; LACTIC ACID; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; SESQUITERPENES;

EID: 33748943848     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Chen XQ, Jin YY. New Pharmacy [M]. 14th ed. Beijing: People's Medical Publishing House, 2001:581.
2. Fu X, Ping Q, Gao Y. Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A PLGA microspheres [J]. J Microencap, 2005, 22:57-66.
3. Ahmad AM, Flanagan DR. Salt and cosolvents effects on ionic drug loading into microsheres using an O/W method [J]. J Control Release, 2001, 70:169-181.
4. Lamprecht A, Schfer UF, Lehr CM. Characterization of microcapsules by confocal laser scanning microscopy: structure, capsule wall composition and encapsulation rate [J]. Eur J Pharm Biopharm, 2000, 49:1-9.
5. Corre PL, Rytting JH, Gajan V, et al. In vitro controlled release kinetics of local anaesthetics from poly (D, L-lactide) and poly (lactide-co-glycolide) microspheres [J]. J Microencap, 1997, 14:243-253.
6. Kyo M, Hyon SH, Ikada Y. Effects of preparation conditions of cisplatin-loaded microspheres on the in vitro release [J]. J Control Release, 1995, 35:73-82.
7. Sansdrap P, Moes AJ. In vitro evaluation of the hydrolytic degradation of dispersed and aggregated poly (D, L-lactide-co-glycolide) microspheres [J]. J Control Release, 1997, 43:47-58.
8. Iwata M, Nakamura Y, Mcginity JW. In vitro and in vivo release properties of brilliant blue and tumour necrosis factor-alpha (TNF-α) from poly (D,L-lactic-co-glycoclic acid) multiphase microspheres [J]. J Microencap, 1999, 16:777-792.
9. Izumikawa S, Yoshioka S, Aso Y, et al. Preparation of poly (L-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate [J]. J Control Release, 1991, 15:133-140.
10. Matsumoto A, Matsukawa Y, Suzuki T, et al. The polymer-alloys method as a new preparation method of biodegradable microspheres: principle and application to cisplatin-loaded microspheres [J]. J Control Release, 1997, 48:19-27.
11. Yang YY, Chung TS, Ng NP. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method [J]. Biomaterials, 2001, 22:231-241.