Interleukin-1 gene complex in schizophrenia: An association study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 141, Issue 6, 2006, Pages 678-680

  Saiz, Pilar A ^a,d   Garcia Portilla, Maria P ^a   Arango, Celso ^b   Morales, Blanca ^c   Martinez Barrondo, Sara ^a   Alvarez, Victoria ^c   Coto, Eliecer ^c   Fernandez, Juan ^a   Bousono, Manuel ^a   Bobes, Julio ^a  

^a UNIVERSIDAD DE OVIEDO   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^d Oviedo University School of Medicine   (Spain)

Author keywords

Genetic association; Interleukin 1 gene complex; Polymorphisms; Schizophrenia

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTPATIENT; PRIORITY JOURNAL; SCHIZOPHRENIA;

ALLELES; GENE FREQUENCY; HUMANS; INTERLEUKIN-1; SCHIZOPHRENIA;

EID: 33748938361     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30394     Document Type: Article

References (20)

1. Chowdari KV, Xu K, Zhang F, Ma C, Li T, Xie BY, Wood J, Trucco M, Tsoi WF, Saha N, Rudert WA, Nimgaonkar VL. 2001. Immune related genetic polymorphisms and schizophrenia among the Chinese. Hum Immunol 62:714-724.
2. Cox A, Camp NJ, Nicklin MJH, di Giovine FS, Duff GW. 1998. An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers. Am J Hum Genet 62:1180-1188.
3. Curtis D, Knight J. 2003. Genecounting Program. http:\\www.mds.qmul. ac.uk/statgen/dcurtis.html. Accessed, November 15, 2005.
4. Danis VA, Millington M, Hyland VJ, Grennan D. 1995. Cytokine production by normal human monocytes: Inter-subject variation and relationship to an IL-1 receptor (IL-1Ra) gene polymorphism. Clin Exp Immunol 99:303-310.
5. First MB, Spitzer RL, Gibbon M, Williams JBW. 2001. Entrevista clínica estructurada para los trastornos del eje I del DSM-IV. SCID-I. Barcelona: Masson.
6. Hurme M, Santtila S. 1998. IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1β genes. Eur J Immunol 28:2598-2602.
7. Katila H, Hanninen K, Hurme M. 1999. Polymorphisms of the interleukin-1 gene complex in schizophrenia. Mol Psychiatry 4:179-181.
8. Kim SJ, Lee HJ, Koo HG, Kim JW, Song JY, Kim MK, Shin DH, Jin SY, Hong MS, Park HJ, Yoon SH, Park HK, Chung JH. 2004. Impact of IL-1 receptor antagonist gene polymorphism on schizophrenia and bipolar disorder. Psychiatr Genet 14:165-167.
9. Laurent C, Thibaut F, Ravassard P, Campion D, Samolyk D, Lafargue C, Petit M, Martinez M, Mallet J. 1997. Detection of two new polymorphic sites in the human interleukin-1β gene: Lack of association with schizophrenia in a French population. Psychiatr Genet 7:103-105.
10. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, et al. 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 73:34-48.
11. Nawa H, Takahashi M, Patterson PH. 2000. Cytokine and growth factor involvement in schizophrenia support for the developmental model. Mol Psychiatry 5:594-603.
12. Nicklin MJ, Weith A, Duff GW. 1994. A physical map of the region encompassing the human interleukin-1α, interleukin-1β, and interleukin-1 receptor antagonist gene. Genomics 19:382-384.
13. Nicklin MJH, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K. 2002. A sequence-based map of the nine genes of the human interleukin-1 cluster. Genomics 79:718-725.
14. Papiol S, Rosa A, Gutierrez B, Martin B, Salgado P, Catalan R, Arias B, Fañanas L. 2004. Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder. J Med Genet 41:219-223.
15. Papiol S, Molina V, Desco M, Rosa A, Reig S, Gispert JD, Sanz J, Palomo T, Fañanas L. 2005. Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene. Neuroimage 27:1002-1006.
16. Rosa A, Peralta V, Papiol S, Cuesta MJ, Serrano F, Martinez-Larrea A, Fañanas L. 2004. Interleukin-1beta (IL-1beta) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders. Am J Med Genet B Neuropsychiatr Genet 124B:10-14.
17. Tatsumi M, Sasaki T, Sakai T, Kamijima K, Fukuda R, Kunugi H, Hattori M, Nanko S. 1997. Genes for interleukin-2 receptor β chain, interleukin-1 β, and schizophrenia: No evidence for the association or linkage. Am J Med Genet 74:338-341.
18. Thomas DC, Witte JS. 2002. Point: Population stratification: A problem for case-control studies of candidate-gene associations? Cancer Epidemiol Biomarkers Prev 11:505-512.
19. Yang J, Si T, Ling Y, Ruan Y, Han Y, Wang X, Zhou M, Zhang D, Zhang H, Kong Q, Liu C, Li X, Yu Y, Liu S, Shu L, Ma D, Wei J, Zhang D. 2003. Association study between interleukin-1beta gene (IL-1beta) and schizophrenia. Life Sci 72:3017-3021.
20. Zanardini R, Bocchio-Chiavetto L, Scassellati C, Bonvicini C, Tura GB, Rossi G, Perez J, Gennarelli M. 2003. Association between IL-1beta-511C/T and IL-1RA (86 bp)n repeats polymorphisms and schizophrenia. J Psychiatr Res 37:457-462.