Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/βcatenin gene regulatory network

Pediatric Research

Volumn 60, Issue 4, 2006, Pages 382-388

  Torday, John S ^a,b   Rehan, Virender K ^a  

^a LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; ADIPOPHILIN; BETA CATENIN; BUMETANIDE; CYCLIC AMP; DISHEVELLED PROTEIN; FRIZZLED PROTEIN; LITHIUM CHLORIDE; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN[7-34] AMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLCHOLINE; PROTEIN; PROTEIN GLI; PROTEIN PATCHED; RECEPTOR BLOCKING AGENT; SONIC HEDGEHOG PROTEIN; SURFACTANT PROTEIN B; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENDODERM; FEMALE; FETUS; GENE EXPRESSION REGULATION; LIPID TRANSPORT; LUNG ALVEOLUS; LUNG DEVELOPMENT; MALE; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BETA CATENIN; BRONCHOALVEOLAR LAVAGE FLUID; BUMETANIDE; DOWN-REGULATION; FETUS; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; LUNG; MEMBRANE PROTEINS; PARATHYROID HORMONE-RELATED PROTEIN; PHOSPHATIDYLCHOLINES; RATS; RATS, SPRAGUE-DAWLEY; TRANS-ACTIVATORS; TRIGLYCERIDES; WNT PROTEINS;

EID: 33748895841     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000238326.42590.03     Document Type: Article

References (40)

1. Bellusci S, Furuta Y, Rush MG, Henderson R, Winnier G, Hogan BL 1997 Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124:53-63
2. Torday JS, Rehan VK 2002 Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptin. Am J Physiol Lung Cell Mol Physiol 283:L130-L135
3. Torday JS, Sanchez-Esteban J, Rubin LP 1998 Paracrine mediators of mechanotransduction in lung development. Am J Med Sci 316:205-208
4. Torday JS, Sun H, Wang L, Torres E, Sunday ME, Rubin LP 2002 Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. Am J Physiol Lung Cell Mol Physiol 282:L405-L410
5. Warburton D, Schwarz M, Tefft D, Flores-Delgado G, Anderson KD, Cardoso WV 2000 The molecular basis of lung morphogenesis. Mech Dev 92:55-81
6. Umek RM, Friedman AD, McKnight SL 1991 CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251:288-292
7. Brody JS, Williams MC 1992 Pulmonary alveolar epithelial cell differentiation. Annu Rev Physiol 54:351-371
8. Boitano S, Isakson BE, Lubman RL 2002 Culturing alveolar type I, alveolar type II, and mixed cell populations by altering the extracellular matrix promotes changes in intercellular signaling mechanisms. Chest 121:35S-36S
9. Torday JS, Rehan VK 2003 Mechanotransduction determines the structure and function of lung and bone: a theoretical model for the pathophysiology of chronic disease. Cell Biochem Biophys 37:235-246
10. Ballard PL, Gonzales LW, Williams MC, Roberts JM, Jacobs MM 1991 Differentiation of type II cells during explant culture of human fetal lung is accelerated by endogenous prostanoids and adenosine 3′, 5′-monophosphate. Endocrinology 128:2916-2924
11. Mendelson CR 2000 Endocrinology of the Lung: Development and Surfactant Synthesis. Humana Press, Totowa, NJ, pp 1-336
12. Boros LG, Torday JS, Paul Lee WN, Rehan VK 2002 Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts. Mol Genet Metab 77:230-236
13. Hastings RH, Ryan RM, D'Angio CT, Holm BA, Patel A, Quintana R, Biederman E, Burton DW, Deftos LJ 2002 Parathyroid hormone-related protein response to hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol 282:L1198-L1208
14. Torday J, Hua J, Slavin R 1995 Metabolism and fate of neutral lipids of fetal lung fibroblast origin. Biochim Biophys Acta 1254:198-206
15. Rehan V, Torday J 2003 Hyperoxia augments pulmonary lipofibroblast-to- myofibroblast transdifferentiation. Cell Biochem Biophys 38:239-250
16. Moss TJ, Nitsos I, Kramer BW, Ikegami M, Newnham JP, Jobe AH 2002 Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep. Am J Obstet Gynecol 187:1059-1065
17. Rubin LP, Kovacs CS, De Paepe ME, Tsai SW, Torday JS, Kronenberg HM 2004 Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev Dyn 230:278-289
18. Rubin LP, Kifor O, Hua J, Brown EM, Torday JS 1994 Parathyroid hormone (PTH) and PTH-related protein stimulate surfactant phospholipid synthesis in rat fetal lung, apparently by a mesenchymal-epithelial mechanism. Biochim Biophys Acta 1223:91-100
19. Speziale MV, Mannino FL, Hastings RH, Deftos LJ 1998 Parathyroid hormone-related protein in tracheal aspirates of newborn infants. Pediatr Res 43:660-665
20. Torday JS, Torres E, Rehan VK 2003 The role of fibroblast transdifferentiation in lung epithelial cell proliferation, differentiation, and repair in vitro. Pediatr Pathol Mol Med 22:189-207
21. Rehan VK, Wang Y, Sugano S, Romero S, Chen X, Santos J, Khazanchi A, Torday JS 2005 Mechanism of nicotine-induced pulmonary fibroblast transdifferentiation. Am J Physiol Lung Cell Mol Physiol 289:L667-L676
22. Bostrom H, Willetts K, Pekny M, Leveen P, Lindahl P, Hedstrand H, Pekna M, Hellstrom M, Gebre-Medhin S, Schalling M, Nilsson M, Kurland S, Tornell J, Heath JK, Betsholtz C 1996 PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 85:863-873
23. Low RB 1999 Modulation of myofibroblast and smooth-muscle phenotypes in the lung. Curr Top Pathol 93:19-26
24. Kapur P, Holm BA, Irish MS, Patel A, Glick PL 1999 Tracheal ligation and mechanical ventilation do not improve the antioxidant enzyme status in the lamb model of congenital diaphragmatic hernia. J Pediatr Surg 34:270-272
25. McCray PB Jr., Bettencourt JD, Bastacky J 1992 Secretion of lung fluid by the developing fetal rat alveolar epithelium in organ culture. Am J Respir Cell Mol Biol 6:609-616
26. Gross I, Smith GJ, Maniscalco WM, Czajka MR, Wilson CM, Rooney SA 1978 An organ culture model for study of biochemical development of fetal rat lung. J Appl Physiol 45:355-362
27. Torday JS 1990 Androgens delay human fetal lung maturation in vitro. Endocrinology 126:3240-3244
28. Kaesler S, Luscher B, Ruther U 2000 Transcriptional activity of GLI1 is negatively regulated by protein kinase A. Biol Chem 381:545-551
29. Walterhouse DO, Lamm ML, Villavicencio E, Iannaccone PM 2003 Emerging roles for hedgehog-patched-Gli signal transduction in reproduction. Biol Reprod 69:8-14
30. McGowan SE, Torday JS 1997 The pulmonary lipofibroblast (lipid interstitial cell) and its contributions to alveolar development. Annu Rev Physiol 59:43-62
31. Alcorn D, Adamson TM, Lambert TF, Maloney JE, Ritchie BC, Robinson PM 1977 Morphological effects of chronic tracheal ligation and drainage in the fetal lamb lung. J Anat 123:649-660
32. Moessinger AC, Harding R, Adamson TM, Singh M, Kiu GT 1990 Role of lung fluid volume in growth and maturation of the fetal sheep lung. J Clin Invest 86:1270-1277
33. Aeberhard EE, Scott ML, Barrett CT, Kaplan SA 1984 Effects of cyclic AMP analogues and phosphodiesterase inhibitors on phospholipid biosynthesis in fetal type II pneumocytes. Biochim Biophys Acta 803:29-38
34. Mendelson CR, Acarregui MJ, Odom MJ, Boggaram V 1991 Developmental and hormonal regulation of surfactant protein A (SP-A) gene expression in fetal lung. J Dev Physiol 15:61-69
35. Huelsken J, Birchmeier W 2001 New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 11:547-553
36. Karperien M, van Dijk TB, Hoeijmakers T, Cremers F, Abou-Samra AB, Boonstra J, de Laat SW, Defize LH 1994 Expression pattern of parathyroid hormone/parathyroid hormone related peptide receptor mRNA in mouse postimplantation embryos indicates involvement in multiple developmental processes. Mech Dev 47:29-42
37. Schultz CJ, Torres E, Londos C, Torday JS 2002 Role of adipocyte differentiation-related protein in surfactant phospholipids synthesis by type II cells. Am J Physiol Lung Cell Mol Physiol 283:L288-L296
38. Burton PB, Moniz C, Quirke P, Malik A, Bui TD, Juppner H, Segre GV, Knight DE 1992 Parathyroid hormone-related peptide: expression in fetal and neonatal development. J Pathol 167:291-296
39. Shannon JM, Hyatt BA 2004 Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol 66:625-645
40. Demayo F, Minoo P, Plopper CG, Schuger L, Shannon J, Torday JS 2002 Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process? Am J Physiol Lung Cell Mol Physiol 283:L510-L517