An examination of the effects of 5-methoxy-N, N-di(iso)propyltryptamine hydrochloride (Foxy) on cognitive development in rats

Psychological Reports

Volumn 98, Issue 3, 2006, Pages 651-661

  Compton, David M ^a   Selinger, Melissa C ^b   Testa, Erin K ^a   Larkins, Krystal D ^a  

^a PALM BEACH ATLANTIC UNIVERSITY   (United States)

^b Wellington High School   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHOXYTRYPTAMINE; 5-METHOXY-N,N-DIISOPROPYLTRYPTAMINE; DRUG DERIVATIVE; N,N DIISOPROPYL 5 METHOXYTRYPTAMINE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; COGNITION; DEPTH PERCEPTION; DRUG EFFECT; EVALUATION; LONG EVANS RAT; PERCEPTION DISORDER; RANDOMIZATION; RAT;

5-METHOXYTRYPTAMINE; ANIMALS; COGNITION; PERCEPTUAL DISORDERS; RANDOM ALLOCATION; RATS; RATS, LONG-EVANS; SPACE PERCEPTION;

EID: 33748879979     PISSN: 00332941     EISSN: 1558691X     Source Type: Journal    
DOI: 10.2466/PR0.98.3.651-661     Document Type: Article

References (30)

1. CHAPIN, D. S., LOOKINGLAND, K. J., & MOORE, K. E. (1994) Effects of LC mobile phase composition on retention times for biogenic amines, and their precursors and metabolites. Current Separations, 7, 68-70.
2. COHEN, N. J., & EICHENBAUM, H. (1993) Memory, amnesia, and the hippocampus, Cambridge, MA: MIT Press.
3. COMPTON, D. M. (2004) Behavior strategy learning in rat: effects of lesions of the dorsal hippocampus. Behavioural Processes, 67, 335-342.
4. 2 noradrenergic antagonist piperoxane. Psychological Record, 47, 321-334.
5. EICHENBAUM, H., FAGAN, A., MATTHEWS, P., & COHEN, N. J. (1988) Hippocampal system dysfunction and odor discrimination learning in rats: impairment of facilitation depending on representational demands. Behavioral Neuroscience, 102, 331-339.
6. EICHENBAUM, H., STEWART, C., & MORRIS, R. G. M. (1991) Hippocampal representation in place learning, Journal of Neuroscience, 10, 3531-3542.
7. FELLOWS, B. J. (1967) Chance stimulus sequences for discrimination trials. Psychological Bulletin, 67, 87-92.
8. FOX, H. C., MCLEAN, A., TURNER, J. J., PARROTT, A. C., ROGERS, R., & SAHAKIAN, B. J. (2002) Neuropsychological evidence of a relatively selective profile of temporal dysfunction in drug-free MDMA ('ecstasy') polydrug users. Psychopharmacology (Berlin), 162, 203-214.
9. HARLOW, H. F. (1949) The formation of learning sets. Psychological Reviews, 56, 51-65.
10. IKEDA, A., SEKIGUCHI, K., FUJITA, K., YAMADERA, H., & KOG, Y. (2005) 5-methoxy-N,N-diisopro-pyltryptamine-induced flashbacks. American Journal of Psychiatry, 162, 815.
11. MARSTON, H. M., REID, M. E., LAWRENCE, J. A., OLVERMAN, H. J., & BUTCHER, S. P. (1999) Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat. Psychopharmacology (Berlin), 144, 67-76.
12. MCCARDLE, K., LUEBBERS, S., CARTER, J. D., CROFT, R. J., & STOUGH, C. (2004) Chronic MDMA (ecstasy) use, cognition, and mood. Psychopharmacology (Berlin), 173, 391-397.
13. MEATHERALL, R., & SHARMA, P. (2003) Foxy, a designer tryptamine hallucinogen, Journal of Analytical Toxicology, 27, 313-317.
14. MORRIS, R. G. M. (1984) Development of a water-maze procedure for studying spatial learning in the rat. Journal of Neuroscience Methods, 11, 47-60.
15. MOYANO, S., FRECHILLA, D., & DEL RIO, J. (2004) NMDA receptor subunit CaMKII changes in the rat hippocampus induced by acute MDMA treatment: a mechanism for learning impairment. Psychopharmacology (Berlin), 173, 337-345.
16. NATIONAL RESEARCH COUNCIL. (1996) Guide for the care and use of laboratory animals. Washington, DC: National Academic Press.
17. PARROTT, A. C. (2001) Human psychopharmacology of ecstasy (MDMA): a review of 15 years of empirical research. Human Psychopharmacology, 16, 557-577.
18. RICAURTE, G. A., MARKOWSKA, A. L., & WENK, G. L. (1993) 3,4-Methylenedioxymethamphetamine, serotonin and memory. Journal of Pharmacology and Experimental Therapeutics, 266, 1097-1105.
19. RICAURTE, G. A., YUAN, J., & MCCANN, U. D. (2000) (+)3,4-methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals. Neumpsvchobiology, 42, 5-10.
20. RUNZHOU, Z., & MCDANIEL, W. F. (1998) Ginseng improves strategic learning by normal and brain-damaged rats. NeuroReport, 9, 1619-1624.
21. SHULGRIN, A., & SHULGRIN, A. (1997) THINKAL (Tryptamines I have known and loved) the continuation. Berkeley, CA: Transform Press.
22. SITARAM, B. R., LOCKETT, L., BLACKMAN, G. L., & MCLEOD, W. R. (1987) Urinary excretion of 5-methoxy-N,N-dimethyltryptamine, N,N-dimethyltryptamine and their N-oxides in the rat. Biochemical Pharmacology, 36, 2235-2237.
23. SMOLINSKE, S., RASTOGI, R., & SCHENKEL, S. (2003) Foxy methoxy: a new drug of abuse. Clinical Toxicology, 41, 641.
24. SPEAR, L. P. (2000) The adolescent brain and age-related behavioral manifestations. Neuroscience and Biohehavioral Reviews, 24, 417-463.
25. SPRAGUE, J. E., PRESTON, A. S., LEIFHEIT, M., & WOODSIDE, B. (2003) Hippocampal serotonergic damage induced by MDMA (ecstasy): effects on spatial learning. Physiology and Behavior, 79, 281-287.
26. TAFFE, M. A., HUITRON-RESENDIZ, S., SCHROEDER, R., PARSONS, L. H., HENRIKSEN, S. J., & GOLD, L. H. (2003) MDMA exposure alters cognitive and electrophysiological sensitivity to rapid serotonin depletion in rhesus monkeys. Pharmacology, Biochemistry, and Behavior, 76, 141-152.
27. TIRELLI, E., LAVIOLA, G., & ADRIANI, W. (2003) Ontogenesis of behavioral sensitization and conditioned place preference in laboratory rodents. Neuroscience and Biobehavioral Reviews, 23, 163-178.
28. UNITED STATES DRUG ENFORCEMENT ADMINISTRATION. (April 4, 2003) Schedules of controlled substances: temporary placement of alpha-methyltryptamine and 5-methoxy-N,Ndiisopro-pyltryptamine into Schedule I: Final rule. Federal Register, 68(65), 16427-16430.
29. WAREING, M., FISK, J. E., & MURPHY, P. (2005) Visuo-spatial working memory deficits in current and former users of MDMA ('ecstasy'). Human Psychopharmacology: Clinical and Experimental, 20, 115-123.
30. WILSON, J. M., MCGEORGE, F., SMOLINSKE, S., & MEATHERALL, R. (2005) A foxy intoxication. Forensic Science International, 148, 31-36.