DNA interstrand crosslinking agents: Synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD)

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5677-5681

  Purnell, Bethany ^a   Sato, Atsushi ^a,b   O'Kelley, Amanda ^a   Price, Carly ^a   Summerville, Kaitlin ^a   Hudson, Stephen ^a   O'Hare, Caroline ^c   Kiakos, Konstantinos ^c   Asao, Tetsuji ^b   Lee, Moses ^a,d   Hartley, John A ^c  

^a FURMAN UNIVERSITY   (United States)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d HOPE COLLEGE   (United States)

Author keywords

Achiral; CC 1065; Dimer; Duocarmycins; Pyrrolobenzodiazepines; Seco amino CBI

Indexed keywords

ADENINE; ALKYLATING AGENT; AMINO ACID; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; DUOCARMYCIN DERIVATIVE; PYRROLOBENZODIAZEPINE DERIVATIVE; RACHELMYCIN; RACHELMYCIN DERIVATIVE; THYMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; AT RICH SEQUENCE; CHIRALITY; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; DNA CROSS LINKING; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; MOUSE; NONHUMAN;

BENZODIAZEPINES; CROSS-LINKING REAGENTS; CYCLOPROPANES; DIMERIZATION; DNA; INDOLES; PYRROLES;

MURINAE;

EID: 33748790445     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.005     Document Type: Article

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