Immunohistochemical staining of urokinase plasminogen activator-like and urokinase plasminogen activator receptor-like proteins in the urinary tract of healthy dogs

American Journal of Veterinary Research

Volumn 67, Issue 9, 2006, Pages 1628-1634

  Bailey, Trina R ^a,b   Paulsen, Daniel B ^a   Sehgal, Inder ^a   Hosgood, Giselle ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; UROKINASE; UROKINASE LIKE PROTEIN; UROKINASE RECEPTOR; UROKINASE RECEPTOR LIKE PROTEIN;

AGE DISTRIBUTION; ANIMAL TISSUE; ARTICLE; BLADDER; CASTRATION; CONTROLLED STUDY; DOG; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KIDNEY PARENCHYMA; MALE; MOLECULAR WEIGHT; NONHUMAN; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROSTATE; PROTEIN ANALYSIS; PROTEIN FUNCTION; SPECIES DIFFERENCE; TESTIS; URETER; URETHRA; URINARY TRACT; URINARY TRACT DISEASE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; DOGS; FEMALE; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; PROSTATE; RECEPTORS, CELL SURFACE; TESTIS; URINARY PLASMINOGEN ACTIVATOR;

ANIMALIA; CANIS FAMILIARIS;

EID: 33748757078     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.67.9.1628     Document Type: Article

References (50)

1. Di Cera E, Krem MM. Serine proteases. Vol 2. London: Macmillan Publishers Ltd, Nature Publishing Group, 2003;1-9.
2. Spraggon G, Phillips C, Nowak UK, et al. The crystal structure of the catalytic domain of human urokinase-type plasminogen activator. Structure 1995;3:681-691.
3. Gellert GC, Goldfarb RH, Kitson RP. Physical association of uPAR with the alpha V integrin on the surface of human NK cells. Biochem Biophys Res Commun 2004;315:1025-1032.
4. Andreasen PA, Kjoller L, Christensen L, et al. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 1997;72:1-22.
5. Blasi F, Carmeliet P. uPAR: a versatile signaling orchestrator. Nat Rev Mol Cell Biol 2002;3:932-943.
6. Behrendt N, Ronne E, Dano K. The structure and function of the urokinase receptor, a membrane protein governing plasminogen activation on the cell surface. Biol Chem Hoppe Seyler 1995;376:269-279.
7. Ray P, Bhatti R, Gadarowski J, et al. Inhibitory effect of amiloride on the urokinase plasminogen activators in prostatic cancer. Tumor Biol 1998; 19:60-64.
8. Yoshida E, Ohmura S, Sugiki M, et al. Prostate-specific antigen activates single-chain urokinase-type plasminogen activator. Int J Cancer 1995;63:863-865.
9. Casella R, Shariat SF, Monoski MA, et al. Urinary levels of urokinase-type plasminogen activator and its receptor in the detection of bladder carcinoma. Cancer 2002;95:2494-2499.
10. Darien BJ. Fibrinolytic system. In: Feldman BF, Zinkel JG, Jain NC, eds. Schalm's veterinary hematology. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2000;544-548.
11. Dubeau L, Jones PA, Rideout WM III, et al. Differential regulation of plasminogen activators by epidermal growth factor in normal and neoplastic human urothelium. Cancer Res 1988;48:5552-5556.
12. du Toit PJ, van Aswegen CH, du Plessis DJ. The effect of essential fatty acids on growth and urokinase-type plasminogen activator production in human prostate DU-145 cells. Prostaglandins Leukot Essent Fatty Acids 1996;55:173-177.
13. Memarzadeh S, Kozak KR, Chang L, et al. Urokinase plasminogen activator receptor: prognostic biomarker for endometrial cancer. Proc Natl Acad Sci U S A 2002;99:10647-10652.
14. Stump DC, Thienpont M, Collen D. Purification and characterization of a novel inhibitor of urokinase from human urine. Quantitation and preliminary characterization in plasma. J Biol Chem 1986;261:12759-12766.
15. Deng FM, Ding M, Lavker RM, et al. Urothelial function reconsidered: a new role in urinary protein secretion. Proc Natl Acad Sci U S A 2001;98:154-159.
16. Repine T, Osswald M. Mennorrhea due to a qualitative deficiency of plasminogen activator inhibitor-1: case report and literature review. Clin Appl Thromb Hemost 1994; 10:293-296.
17. Stepanova VV, Tkachuk VA. Urokinase as a multidomain protein and polyfunctional cell regulator. Biochemistry (Mosc) 2002;67:109-118.
18. Florquin S, van den Berg JG, Olszyna DP, et al. Release of urokinase plasminogen activator receptor during urosepsis and endotoxemia. Kidney Int 2001;59:2054-2061.
19. Chavakis T, Kanse SM, May AE, et al. Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation. Biochem Soc Trans 2002;30:168-173.
20. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
21. Prewitt RM, Hoy C, Kong A, et al. Thrombolytic therapy in canine pulmonary embolism. Comparative effects of urokinase and recombinant tissue plasminogen activator. Am Rev Respir Dis 1990;141:290-295.
22. Schaller J, Nick H, Rickli EE, et al. Human low-molecular-weight urinary urokinase. Partial characterization and preliminary sequence data of two polypeptide chains. Eur J Biochem 1982;125:251-257.
23. Blasi F, Stoppelli MP, Cubellis MV. The receptor for urokinase-plasminogen activator. J Cell Biochem 1986;32:179-186.
24. Bequaj S, Shah AM, Ryan JM. Identification of cells responsible for urokinase-type plasminogen activator synthesis and secretion in human diploid kidney cell cultures. In Vitro Cell Dev Biol 2004;40:102-107.
25. Hayashi S, Yamada K. Presence of urokinase-converting protease in the cultured medium of human kidney cells. Nippon Ketsueki Gakkai Zasshi 1988;51:130-136.
26. Larsson LI, Skriver L, Nielsen LS, et al. Distribution of urokinase-type plasminogen activator immunoreactivity in the mouse. J Cell Biol 1984;98:894-903.
27. Rondeau E, Ochi S, Lacave R, et al. Urokinase synthesis and binding by glomerular epithelial cells in culture. Kidney Int 1989;36:593-600.
28. Andrassy K, Buchholz L, Bleyl U, et al. Topography of human urokinase activity in renal tissue. Nephron 1976;16:213-219.
29. Andrassy K, Ritz E. Isolation and renal localization of urokinase. In: Dubach UC, Schmidt U, eds. Proceedings of the International Symposium on the Biochemical Aspects of the Diagnostic Value of Urine. Bern, Switzerland: Hans Huber Publishers, 1979;330-341.
30. Kenichi M, Masanobu M, Takehiko K, et al. Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor. J Lab Clin Med 2004;144:69-77.
31. Xu Y, Hagege J, Mougenot B, et al. Different expression of the plasminogen activation system in renal thrombotic microangiopathy and the normal human kidney. Kidney Int 1996; 50:2011-2019.
32. Roelofs JJ, Rowshani AT, van den Berg JG, et al. Expression of urokinase plasminogen activator and its receptor during acute renal allograft rejection. Kidney Int 2003;64:1845-1853.
33. Tang W, Freiss H, di Mola FF, et al. Activation of the serine proteinase system in chronic kidney rejection. Transplantation 1998;65:1628-1634.
34. Wilson MJ, Sinha AA, Powell JE, et al. Plasminogen activator activities in the developing rat prostate. Biol Reprod 1988; 38:723-731.
35. Wilson MJ, Ditmanson JD, Sinha AA, et al. Plasminogen activator activities in the ventral and dorsolateral prostatic lobes of aging Fischer 344 rats. Prostate 1990;16:147-161.
36. Andreasen PA, Kristensen P, Lund LR, et al. Urokinase-type plasminogen activator is increased in the involuting ventral prostate of castrated rats. Endocrinology 1990;126:2567-2575.
37. Wilson MJ. Proteases in prostate development, function, and pathology. Microsc Res Tech 1995;30:305-318.
38. Wilson MJ, Norris H, Woodson M, et al. Effects of aging and castration on plasminogen activator and metalloprotease activities in the rat prostate complex. Cell Mol Biol Res 1995;41:603-612.
39. Zhang T, Guo CX, Hu ZY, et al. Localization of plasminogen activator and inhibitor, LH and androgen receptors and inhibin subunits in monkey epididymis. Mol Hum Reprod 1997;3:945-952.
40. Zhang T, Zhou HM, Liu YX. Expression of plasminogen activator and inhibitor, urokinase receptor and inhibin subunits in rhesus monkey testes. Mol Hum Reprod 1997;3:223-231.
41. Huang X, Xia W, Xiong C, et al. Studies on the relationship between urokinase plasminogen activator (uPA) and human sperm motility. J Tongji Med Univ 1997;17:213-217.
42. Zhou H, Vassalli JD. The receptor for urokinase-type plasminogen activator is expressed during mouse spermatogenesis. FEBS Lett 1997;413:11-15.
43. Moriwaki H, Stempien-Otero A, Kremen M, et al. Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice. Circ Res 2004;95:637-644.
44. Pejler G, Winberg J, Vuong TT, et al. Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans. Eur J Biochem 2003;270:3971-3980.
45. Usher PA, Thomsen OF, Iverson P, et al. Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue. Int J Cancer 2005;113:870-880.
46. Rao NK, Shi G, Chapman HA. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. J Clin Invest 1995;96:465-474.
47. Hildenbrand R, Dilger I, Horlin A, et al. Urokinase and macrophages n tumor angiogenesis. Br J Cancer 1995;72:818-823.
48. Lange-Sperandio B, Schimpgen K, Rodenbeck B, et al. Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy. Kidney Int 2006;60:81-88.
49. Evans DM, Sloan-Stakleff KD. Maximum effect of urokinase plasminogen activator inhibitors in the control of invasion and metastasis of rat mammary cancer. Invasion Metastasis 1998-99;18:252-260.
50. Lee SW, Kahn ML, Dichek DA. Expression of an anchored urokinase in the apical endothelial cell membrane. J Biol Chem 1992;267:13020-13027.