Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans

European Journal of Biochemistry

Volumn 270, Issue 19, 2003, Pages 3971-3980

  Pejler, Gunnar ^a   Winberg, Jan Olof ^b   Vuong, Tram T ^c   Henningsson, Frida ^a   Uhlin Hansen, Lars ^b   Kimata, Koji ^d   Kolset, Svein O ^c  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF TROMSØ   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Matrix metalloproteinase; Proteoglycan; Secretion; Urokinase; Xyloside

Indexed keywords

AMILORIDE; GELATINASE B; PHORBOL 13 ACETATE 12 MYRISTATE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEOGLYCAN; THIOXYL DERIVATIVE; UROKINASE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; GELATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; WESTERN BLOTTING; ZYMOGRAPHY;

AMILORIDE; ANIMALS; CELLS, CULTURED; GLYCOSIDES; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MICE; MICROSCOPY, ELECTRON; OLIGOPEPTIDES; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEOGLYCANS; SERINE ENDOPEPTIDASES; TETRADECANOYLPHORBOL ACETATE; URINARY PLASMINOGEN ACTIVATOR;

ANIMALIA; MURINAE;

EID: 0141815493     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03785.x     Document Type: Article

References (37)

1. Nathan, C.F. (1987) Secretory products of macrophages. J. Clin. Invest. 79, 319-326.
2. Uhlin-Hansen, L., Wik, T., Kjellen, L., Berg, E., Forsdahl, F. & Kolset, S.O. (1993) Proteoglycan metabolism in normal and inflammatory human macrophages. Blood 82, 2880-2889.
3. Oynebraten, I., Hansen, B., Smedsrod, B. & Uhlin-Hansen, L. (2000) Serglycin secreted by leukocytes is efficiently eliminated from the circulation by sinusoidal scavenger endothelial cells in the liver. J. Leukoc. Biol. 67, 183-188.
4. Yeaman, C. & Rapraeger, A.C. (1993) Membrane-anchored proteoglycans of mouse macrophages: P388D1 cells express a syndecan-4-like heparan sulfate proteoglycan and a distinct chondroitin sulfate form. J. Cell Physiol. 157, 415-425.
5. Clasper, S., Vekemans, S., Fiore, M., Plebanski, M., Wordsworth, P., David, G. & Jackson, D.G. (1999) Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 (fibroglycan) on human activated macrophages can regulate fibroblast growth factor action. J. Biol. Chem. 274, 24113-24123.
6. Uhlin-Hansen, L., Eskeland, T. & Kolset, S.O. (1989) Modulation of the expression of chondroitin sulfate proteoglycan in stimulated human monocytes. J. Biol. Chem. 264, 14916-14922.
7. Forsberg, E., Pejler, G., Ringvall, M., Lunderius, C., Tomasini-Johansson, B., Kusche-Gullberg, M., Eriksson, I., Ledin, J., Hellman, L. & Kjellen, L. (1999) Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Nature 400, 773-776.
8. Humphries, D.E., Wong, G.W., Friend, D.S., Gurish, M.F., Qiu, W.T., Huang, C., Sharpe, A.H. & Stevens, R.L. (1999) Heparin is essential for the storage of specific granule proteases in mast cells. Nature 400, 769-772.
9. Pejler, G. & Sadler, J.E. (1999) Mechanism by which heparin proteoglycan modulates mast cell chymase activity. Biochemistry 38, 12187-12195.
10. Hallgren, J., Spillmann, D. & Pejler, G. (2001) Structural requirements and mechanism for heparin-induced activation of a recombinant mouse mast cell tryptase, mouse mast cell protease-6: formation of active tryptase monomers in the presence of low molecular weight heparin. J. Biol. Chem. 276, 42774-42781.
11. Tchougounova, E. & Pejler, G. (2001) Regulation of extravascular coagulation and fibrinolysis by heparin-dependent mast cell chymase. FASEB J. 15, 2763-2765.
12. Kolset, S.O., Mann, D.M., Uhlin-Hansen, L., Winberg, J.O. & Ruoslahti, E. (1996) Serglycin-binding proteins in activated macrophages and platelets. J. Leukoc. Biol. 59, 545-554.
13. Toyama-Sorimachi, N., Kitamura, F., Habuchi, H., Tobita, Y., Kimata, K. & Miyasaka, M. (1997) Widespread expression of chondroitin sulfate-type serglycins with CD44 binding ability in hematopoietic cells. J. Biol. Chem. 272, 26714-26719.
14. Kolset, S.O., Sakurai, K., Ivhed, I., Overvatn, A. & Suzuki, S. (1990) The effect of beta-D-xylosides on the proliferation and proteoglycan biosynthesis of monoblastic U-937 cells. Biochem. J. 265, 637-645.
15. Halvorsen, B., Aas, U.K., Kulseth, M.A., Drevon, C.A., Christiansen, E.N: & Kolset, S.O. (1998) Proteoglycans in macrophages: characterization and possible role in the cellular uptake of lipoproteins. Biochem. J. 331, 743-752.
16. Winberg, J.O., Kolset, S.O., Berg, E. & Uhlin-Hansen, L. (2000) Macrophages secrete matrix metalloproteinase 9 covalently linked to the core protein of chondroitin sulfate proteoglycans. J. Mol. Biol. 304, 669-680.
17. Heussen, C. & Dowdle, E.B. (1980) Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal. Biochem. 102, 196-202.
18. Svendsrud, D.H., Loennechen, T. & Winberg, J.O. (1997) Effect of adenosine analogues on the expression of matrix metalloproteinases and their inhibitors from human dermal fibroblasts. Biochem. Pharmacol. 53, 1511-1520.
19. Shively, J.E. & Conrad, H.E. (1976) Formation of anhydrosugars in the chemical depolymerization of heparin. Biochemistry 15, 3932-3942.
20. Vassalli, J.D. & Belin, D. (1987) Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett. 214, 187-191.
21. Novokhatny, V., Medved, L., Mazar, A., Marcotte, P., Henkin, J. & Ingham, K. (1992) Domain structure and interactions of recombinant urokinase-type plasminogen activator. J. Biol. Chem. 267, 3878-3885.
22. Shapiro, S.D., Campbell, E.J., Senior, R.M. & Welgus, H.G. (1991) Proteinases secreted by human mononuclear phagocytes. J. Rheumatol. 27, 95-98.
23. Jones, C.M., Goldfarb, R.H. & Holden, H.T. (1983) Macrophage cell lines behave as activated macrophages in the production and regulation of plasminogen activator. Cancer Invest. 1, 207-213.
24. Carmeliet, P. & Collen, D. (1996) Gene manipulation and transfer of the plasminogen and coagulation system in mice. Semin. Thromb. Hemost. 22, 525-542.
25. Vassalli, J.D. & Pepper, M.S. (1994) Tumour biology. Membrane proteases in focus. Nature 370, 14-15.
26. Khan, K.M. & Falcone, D.J. (1997) Role of laminin in matrix induction of macrophage urokinase-type plasminogen activator and 92-kDa metalloproteinase expression. J. Biol. Chem. 272, 8270-8275.
27. Falcone, D.J., McCaffrey, T.A., Haimovitz-Friedman, A., Vergilio, J.A. & Nicholson, A.C. (1993) Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation. J. Biol. Chem. 268, 11951-11958.
28. Opdenakker, G., Van den Steen, P.E. & Van Damme, J. (2001) Gelatinase B: a tuner and amplifier of immune functions. Trends Immunol. 22, 571-579.
29. Brunner, G., Reimbold, K., Meissauer, A., Schirrmacher, V. & Erkell, L.J. (1998) Sulfated glycosaminoglycans enhance tumor cell invasion in vitro by stimulating plasminogen activation. Exp. Cell Res. 239, 301-310.
30. Metkar, S.S., Wang, B., Aguilar-Santelises, M., Raja, S.M., Uhlin-Hansen, L., Podack, E., Trapani, J.A. & Froelich, C.J. (2002) Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity 16, 417-428.
31. Spaeny-Dekking, E.H., Kamp, A.M., Froelich, C.J. & Hack, C.E. (2000) Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors. Blood 95, 1465-1472.
32. Schmidt, K., Dartsch, H., Linder, D., Kern, H.F. & Kleene, R. (2000) A submembranous matrix of proteoglycans on zymogen granule membranes is involved in granule formation in rat pancreatic acinar cells. J. Cell Sci. 113, 2233-2242.
33. Lemansky, P. & Hasilik, A. (2001) Chondroitin sulfate is involved in lysosomal transport of lysozyme in U937 cells. J. Cell Sci. 114, 345-352.
34. Duval-Jobe, C. & Parmely, M.J. (1994) Regulation of plasminogen activation by human U937 promonocytic cells. J. Biol. Chem. 269, 21353-21357.
35. Henningsson, F., Ledin, J., Lunderius, C., Wilen, M., Hellman, L. & Pejler, G. (2002) Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxy-peptidase A processing. Biol. Chem. 383, 793-801.
36. Schick, B.P., Gradowski, J.F. & San Antonio, J.D. (2001) Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells. Blood 97, 449-458.
37. Hildenbrand, R., Jansen, C., Wolf, G., Bohme, B., Berger, S., von Minckwitz, G., Horlin, A., Kaufmann, M. & Stutte, H.J. (1998) Transforming growth factor-beta stimulates urokinase expression in tumor-associated macrophages of the breast. Laboratory Invest. 78, 59-71.