Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease

Biochemical Journal

Volumn 398, Issue 3, 2006, Pages 345-352

  Xu, Zheng ^a   Chau, So Fun ^a   Lam, Kwok Ho ^a   Chan, Ho Yin ^a   Ng, Tzi Bun ^a   Au, Shannon W N ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Conjugation; Cysteine protease; De conjugation; Maturation; Small ubiquitin related modifier (Sumo); Thioester linkage

Indexed keywords

CATALYSIS; CONFORMATIONS; CRYSTAL STRUCTURE; HYDROLYSIS; METABOLISM; REACTION KINETICS;

CONJUGATION; CYSTEINE PROTEASE; DE-CONJUGATION; MATURATION; SMALL UBIQUITIN-RELATED MODIFIER (SUMO); THIOESTER LINKAGE;

PROTEINS;

AMINO ACID; CYSTEINE; MUTANT PROTEIN; PROTEINASE; SERINE; SUMO PROTEIN; SUMO SPECIFIC PROTEASE 1; THIOESTER; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; SENP1 PROTEIN, HUMAN; SENP2 PROTEIN, HUMAN; SUMO 1 PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CELL CYCLE PROGRESSION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; X RAY DIFFRACTION; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SUMO-1 PROTEIN;

EID: 33748754202     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060526     Document Type: Article

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