Alcoholism and AIDS: Magnetic resonance imaging approaches for detecting interactive neuropathology

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 7, 2002, Pages 1031-1046

  Pfefferbaum, Adolf ^a,b   Rosenbloom, Margaret ^a,b   Sullivan, Edith V ^b  

^a SRI INTERNATIONAL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Alcohol; Brain; Comorbidity; HIV; MRI

Indexed keywords

PROTON;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AGE; AGING; ALCOHOLISM; BRAIN FUNCTION; BRAIN REGION; CADAVER; CELL TYPE; CLINICAL TRIAL; DISEASE ASSOCIATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMAGING; IN VIVO STUDY; NEUROPATHOLOGY; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PREVALENCE; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS; WHITE MATTER; METHODOLOGY; PATHOLOGY; PSYCHOLOGICAL ASPECT;

HUMAN IMMUNODEFICIENCY VIRUS;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AGING; ALCOHOLISM; HUMANS; MAGNETIC RESONANCE IMAGING;

EID: 0035995988     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2002.tb02638.x     Document Type: Review

References (242)

1. Brain magnetic resonance: Biochemical, functional, and microstructural imaging
2. Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage
3. Hippocampal volume in patients with alcohol dependence
4. Demyelination of the mamillary bodies in alcoholism. A combined morphological and biochemical study
5. White-matter hyperintensity and neuropsychological functions in dementia and healthy aging
6. Axonal damage revealed by accumulation of beta-APP in HIV-positive individuals without AIDS
7. Early HIV-1 infection of the central nervous system
8. The use of magnetic resonance spectroscopy in the evaluation of the natural history of multiple sclerosis
9. Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia
10. Reduced basal ganglia volume in HIV-1-associated dementia: Results from quantitative neuroimaging
11. Quantitative proton spectroscopy of canine brain: In vivo and in vitro correlations
12. AIDS dementia complex: Evaluation with proton MR spectroscopic imaging
13. Proton MRSI in HIV+ patients: Effect of highly active antiretroviral therapy
14. Microstructural and physiological features of tissues elucidated by quantitative diffusion tensor MRI
15. Chronic alcohol intoxication attenuates human immunodeficiency virus-1 glycoprotein 120-induced superoxide anion release by isolated Kupffer cells
16. Visuospatial perception, construction and memory in alcoholism
17. Problem-solving deficits in alcoholics: Evidence from the California Card Sorting Test
18. Learning to associate names and faces: Impaired acquisition on an ecologically relevant memory task by male alcoholics
19. The neuropathology of adult HIV infection
20. HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS. Effect of neocortical involvement
21. Effect of chronic alcoholism on neuronal nuclear size and neuronal population in the mammillary body and the anterior thalamic complex of man
22. Diffusion tensor imaging in HIV infection: What is it telling us?
23. Cerebrovascular changes in the basal ganglia with HIV dementia
24. Magnetic resonance imaging of white matter lesions in HIV infection
25. Drug and alcohol use and neuropsychological performance in asymptomatic HIV infection
26. Change in neuropsychological performance in asymptomatic HIV infections: 1-Year follow-up
27. NMR studies on the energy metabolism of glial and neuronal cells
28. Cognitive loss and recovery in long-term alcohol abusers
29. Cytomegalovirus encephalitis and primary cerebral lymphoma mimicking Wernicke's encephalopathy
30. MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
31. Assessment of ADIS-related cognitive changes: Recommendations of the NIMH Workshop on Neuropsychological Assessment Approaches
32. Cerebral dysfunction in chronic alcoholism: Role of alcoholic liver disease
33. Thiamine-dependent enzyme changes in the brains of alcoholics-relationship to the Wernicke-Korsakoff syndrome
34. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins
35. Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients
36. Proton MR spectroscopy in inflammatory and infectious brain disorders
37. In vivo magnetic resonance spectroscopy in HIV and HIV-related brain diseases
38. MR spectroscopy and diffusion-weighted MR imaging in focal brain lesions in AIDS
39. Perfusion MRI detects rCBF abnormalities in early stages of HIV-cognitive motor complex
40. Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex
41. Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia
42. In vivo proton magnetic resonance spectroscopy of the normal aging human brain
43. Cerebral metabolite abnormalities in antiretroviral-naive HIV patients before and after HAART
44. Brain lesions in patients with AIDS: H-1 MR spectroscopy
45. Brain lesions in alcoholics
46. Toxoplasmosis and primary central nervous system lymphoma in HIV infection: Diagnosis with MR spectroscopy
47. Localized cerebral proton MR spectroscopy in HIV infection and AIDS
48. Proton spectroscopy of the brain in HIV infection: Correlation with clinical, immunologic, and MR imaging findings
49. Alcohol and human immunodeficiency virus infection
50. Mammillary body and cerebellar shrinkage in chronic alcoholics: An MRI and neuropsychological study
51. Disproportionate atrophy of cerebral white matter in chronic alcoholics
52. Prevalence and predictors of depressive, anxiety and substance use disorders in HIV-infected and uninfected men: A longitudinal evaluation
53. Pathophysiology of ataxia in humans
54. Is alcohol a cofactor of HIV and AIDS? Evidence from immunological and behavioral studies
55. Brain atrophy in HIV infection is more strongly associated with CDC clinical stage than with cognitive impairment
56. Magnetization transfer imaging in AIDS-related brain diseases
57. Relative concentration of proton MR visible neurochemicals in gray and white matter in human brain
58. Elevated frontal lobe cytosolic choline levels in minimal or mild AIDS dementia complex patients: A proton magnetic resonance spectroscopy study
59. Frontotemporal dementia and early Alzheimer disease: Differentiation with frontal lobe H-1 MR spectroscopy
60. Progressive multifocal leukoencephalopathy and human immunodeficiency virus-associated white matter lesions in AIDS: Magnetization transfer MR imaging
61. 1H MRS and SPECT study
62. Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder
63. Effects of alcohol and drug use on neuropsychological performance in HIV asymptomatic individuals
64. Alcohol abuse and HIV infection have additive effects on frontal cortex function as measured by auditory evoked potential P3A latency
65. Effect of chronic alcohol abuse on the CNS morbidity of HIV disease
66. 1H Magnetic resonance spectroscopic imaging separates neuronal from glial changes in alcohol-related brain atrophy
67. Diffusion tensor imaging of patients with HIV and normal-appearing white matter on MR images of the brain
68. Proton MR spectroscopic findings correspond to neuropsychological function in traumatic brain injury
69. MR imaging of white matter lesions in uncomplicated chronic alcoholism
70. Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues
71. Neuropsychological and neurological function of human immunodeficiency virus seropositive asymptomatic individuals
72. Aging, abstinence and medical risk factors in the prediction of neuropsychologic deficit among long-term alcoholics
73. Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Studies with neuropsychologic testing and magnetic resonance imaging
74. Neuropsychological and NMR abnormalities in HIV infection: The St. Mary's-Queen Square study
75. Depressed mood does not explain neuropsychological deficits in HIV-infected persons
76. Inverse correlation between choline magnetic resonance spectroscopy signal intensity and the apparent diffusion coefficient in human glioma
77. Chronic alcohol consumption does not cause hippocampal neuron loss in humans
78. The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain?
79. Nutritional and metabolic disorders
80. Patterns of neuronal loss in the cerebral cortex in chronic alcoholic patients
81. Corpus callosal thickness in alcoholics
82. Are we drinking our neurones away?
83. Brain shrinkage in chronic alcoholics: A pathological study
84. How important are brain banks for alcohol research?
85. Evidence of CNS impairment in HIV infection: Clinical, neuropsychological, EEG, and MRI/MRS study
86. The HNRC 500-neuropsychology of HIV infection at different disease stages
87. Muscarinic and nicotinic receptor changes in the cortex and thalamus of brains of chronic alcoholics
88. 1H spectroscopic imaging of human brain at 4.1 T using image segmentation
89. HIV and AIDS - United States 1981-2000
90. Decreased corpus callosum size among alcoholic women
91. Evidence for a gender-related effect of alcoholism on brain volumes
92. Diffuse axonal injury by simple fall
93. Brain metabolite changes in alcoholism: An in vivo proton magnetic resonance spectroscopy (MRS) study
94. Neurological and neuropsychological manifestations of HIV-1 infection: Association with AIDS-related complex but not asymptomatic HIV-1 infection
95. Proton MR spectroscopy of HIV-infected patients - Characterization of abnormalities with imaging and clinical correlation
96. Differential association of HIV-related neuropsychological impairment with semantic versus repetition priming
97. Magnetic resonance imaging morphometric analysis of cerebral volume loss in human immunodeficiency virus infection
98. Cerebral structure on MRI. I. Localization of age-related changes
99. Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging
100. Reduction of blood flow in cerebral white matter in alcoholics related to hepatic function
101. Frontal lobe function in Korsakoff and non-Korsakoff alcoholics: Planning and spatial working memory
102. N-Acetyl-aspartyl-glutamate: Regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method
103. Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations
104. The cerebral cortex is damaged in chronic alcoholics
105. Alcohol abuse and stage of HIV disease in intravenous drug abusers
106. Ethanol and white matter damage in the brain
107. Neuropathology of thiamine deficiency: An update on the comparative analysis of human disorders and experimental models
108. HIV-related metabolic abnormalities in the brain: Depiction with proton MR spectroscopy with short echo times
109. Recovery of visual-spatial learning and memory in chronic alcoholics
110. Effects of hypernatremia on organic brain osmoles
111. Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia
112. Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging
113. Estimating NAA in cortical gray matter with applications for measuring changes due to aging
114. Dopamine systems in human immunodeficiency virus-associated dementia
115. High spatial resolution MRI and proton MRS of human frontal cortex
116. Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy
117. A preliminary report on the neuropsychologic sequelae of human immunodeficiency virus
118. Serial MRI of the brain in asymptomatic patients infected with HIV: Results from the UCMSM/Medical Research Council neurology cohort
119. Absence of N-acetylaspartate in the human brain: Impact on neurospectroscopy?
120. Brain proton magnetic resonance spectroscopy studies in recently abstinent alcoholics
121. Changes in pathological findings at autopsy in AIDS cases for the last 15 years
122. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders
123. Incidental white matter hyperintensities on magnetic resonance imaging in HIV-1 infection
124. Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment
125. Proton MR spectroscopy of the brain in AIDS dementia complex
126. Effects of alcohol and HIV infection on the central nervous system
127. Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients
128. Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus seropositive individuals - In vivo H-1 magnetic resonance spectroscopic imaging
129. Effects of chronic alcohol abuse and HIV infection on brain phosphorus metabolites
130. Deep gray matter structures in HIV infection: A proton MR spectroscopic study
131. Absolute concentrations of metabolites in the adult human brain in vivo - Quantification of localized proton MR spectra
132. The role of magnetic resonance techniques in understanding and managing multiple sclerosis
133. Neuropsychological performance in HIV-1-infected homosexual men: The Multicenter AIDS Cohort Study (MACS)
134. Central pontine myelinolysis in AIDS
135. Abnormal cerebral metabolite concentrations in patients with probable Alzheimer's disease
136. Metabolic characterization of AIDS dementia complex by spectroscopic imaging
137. Anisotropy in diffusion-weighted MRI
138. High spatial resolution MRS and segmented MRI to study NAA in cortical gray matter and white matter of the human brain
139. N-acetyl-aspartic acid content of human neural tumours and bovine peripheral nervous tissue
140. Regional in vivo proton magnetic resonance spectroscopy of brain
141. The AIDS dementia complex. II: Neuropathology
142. Frequency and topographical distribution of CD68-positive macrophages and HIV-1 core proteins in HIV-associated brain lesions
143. Alcohol-related efficiency deficits using an ecologically valid test
144. Behavioral dysfunction and cognitive efficiency in male and female alcoholics
145. Regional and global changes in cerebral diffusion with normal aging
146. Signs of cognitive change in HIV disease - An event-related brain potential study
147. Effects of abstinence on the brain: Quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuse
148. Frontal lobe changes after chronic alcohol ingestion
149. Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline
150. Depression and neuropsychological performance in asymptomatic HIV infection
151. Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging
152. Impaired neuropsychological cognitive functioning in sober alcoholics
153. Cognitive functioning in sober social drinkers: A review of the research since 1986
154. Alcohol consumption as a cofactor in the progression of HIV infection and AIDS
155. Symbiosis between in vivo and in vitro NMR spectroscopy: The creatine, N-acetylaspartate, glutamate and GABA content of the epileptic human brain
156. In vivo brain concentrations of N-acetyl compounds, creatine and choline in Alzheimer's disease
157. In vivo spectroscopic quantification of the N-acetyl moiety, creatine and choline from large volumes of gray and white matter: Effects of normal aging
158. Reorganization of frontal systems used by alcoholics for spatial working memory: An fMRI study
159. Thinning of the corpus callosum in older alcoholic men: A magnetic resonance imaging study
160. Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: A quantitative MRI study
161. Microstructural but not macrostructural disruption of white matter in women with chronic alcoholism
162. Genetic regulation of regional microstructure of the corpus callosum in late life
163. In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism
164. Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging
165. Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics
166. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics
167. A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval
168. A quantitative histological study of the cerebellar vermis in alcoholic patients
169. Towards a quantitative assessment of diffusion anisotropy
170. White matter abnormalities in HIV-1 infection: A diffusion tensor imaging study
171. Asymptomatic and neurologically symptomatic HIV-seropositive subjects: Results of long-term MR imaging and clinical follow-up
172. Progressive multifocal leukoencephalopathy in AIDS: Are there any MR findings useful to patient management and predictive of patient survival?
173. Asymptomatic and neurologically symptomatic HIV-seropositive individuals - Prospective evaluation with cranial MR imaging
174. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS
175. Specific memory deficits associated with prolonged alcohol abuse
176. Nuclear medicine applications to the neuroimaging of AIDS. A neuroradiologist's perspective
177. HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study. 1990-1998
178. Psychomotor slowing in HIV infection: A predictor of dementia, AIDS and death
179. Brain proton magnetic resonance spectroscopy in HIV-related encephalopathy: Identification of evolving metabolic patterns in relation to dementia and therapy
180. Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS
181. Alzheimer disease: Quantitative H-1 MR spectroscopic imaging of frontoparietal brain
182. Elevated myo-inositol in gray matter of recently detoxified but not long-term abstinent alcoholics: A preliminary MR spectroscopy study
183. 1H magnetic resonance spectroscopy investigation of alcohol-associated frontal lobe injury
184. Cerebellar degeneration associated with HIV infection
185. Localized proton magnetic resonance spectroscopy of the cerebellum in detoxifying alcoholics
186. HIV-1 infection - No evidence of cognitive decline during the asymptomatic stages
187. Volumetric magnetic resonance imaging quantification of longitudinal brain changes in abstinent alcoholics
188. Mammillary body and cerebellar shrinkage in chronic alcoholics with and without amnesia
189. Size of mamillary bodies in health and disease: Useful measurements in neuroradiological diagnosis of Wernicke's encephalopathy
190. Probable Alzheimer disease: Diagnosis with proton MR spectroscopy
191. 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV
192. Quantitative proton MR spectroscopic imaging of the human brain
193. Brain HIV burden and length of survival after AIDS diagnosis
194. Diffusion-weighted imaging of clinical stroke
195. Influence of cognitive reserve on neuropsychological functioning in asymptomatic human immunodeficiency virus-1 infection
196. Ethanol suppression of the functional state of polymorphonuclear leukocytes obtained from uninfected and simian immunodeficiency virus infected rhesus macaques
197. In vitro ethanol suppresses alveolar macrophage TNF-α during simian immunodeficiency virus infection
198. Progressive cerebral volume loss in human immunodeficiency virus infection: A longitudinal volumetric magnetic resonance imaging study
199. Human brain vulnerability to alcoholism: Evidence from neuroimaging studies
200. Equivalent disruption of regional white matter microstructure in aging healthy men and women
201. N-Acetyl aspartate - A marker of neuronal integrity
202. Cerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: Relation to ataxia
203. Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia
204. Speed and efficiency but not accuracy or timing deficits of limb movements in alcoholic men and women
205. In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics
206. Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics
207. Relationship between alcohol withdrawal seizures and temporal lobe white matter volume deficits
208. The contribution of constructional accuracy and organizational strategy to nonverbal recall in schizophrenia and chronic alcoholism
209. Factors of the Wisconsin Card Sorting Test as a test of dorsolateral prefrontal cortical function in schizophrenia and alcoholism
210. MR relaxometry reveals central pontine abnormalities in clinically asymptomatic alcoholic men
211. Pattern of motor and cognitive deficits in detoxified alcoholic men
212. Patterns of content, contextual, and working memory impairment in schizophrenia and nonamnesic alcoholism
213. Survival after introduction of Haart in people with known duration of Hiv-1 infection. The Cascade Collaboration. Concerted Action on SeroConversion to AIDS and Death in Europe
214. Magnetic resonance spectroscopy of the brain in neurologically asymptomatic HIV-infected patients
215. Does an increase in sulcal or ventricular fluid predict where brain tissue is lost?
216. Alcohol and AIDS - Is the relationship all in our heads?
217. Cerebellar degeneration associated with human immunodeficiency virus infection
218. Studies on the distribution of N-acetyl-L-aspartate acid in brain
219. fMRI measurement of brain dysfunction in alcohol-dependent young women
220. Morphological changes in the corpus callosum in chronic alcoholism
221. Multifactorial etiology of neuropsychological impairment in alcoholics
222. Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging
223. Increased cerebral blood volume in HIV-positive patients detected by functional MRI
224. From human immunodeficiency virus (HIV) infection of the brain to dementia
225. Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex?
226. Utility of DWI, tensor imaging, and MR spectroscopy in HIV patients with normal brain MR scans
227. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro
228. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types
229. The relationship between age and cognitive impairment in HIV-1 infection: Findings from the Multicenter AIDS Cohort Study and a clinical cohort
230. Normal aging and the subcortical encephalopathy of AIDS: A neuropsychological comparison
231. Basal ganglia metabolite abnormalities in minor motor disorders associated with human immunodeficiency virus type 1
232. 1H magnetic resonance spectroscopy
233. Is alcohol consumption a cofactor in the development of acquired immunodeficiency syndrome?
234. Distribution of brain HIV load in AIDS
235. Implications of self-reported cognitive and motor dysfunction in HIV-positive patients
236. Proton MRS and quantitative MRI assessment of the short term neurological response to antiretroviral therapy in AIDS
237. Alcohol, sex, age, and the hippocampus
238. Hand movement speed and accuracy in detoxified alcoholics
239. Cerebral lymphomas in AIDS. Neuropathological study