Biotransformation and pharmacokinetics of the antiplasmodial naphthylisoquinoline alkaloid dioncophylline A

Xenobiotica

Volumn 36, Issue 9, 2006, Pages 750-762

  Sieber, M ^a   Dekant, W ^a   Faber, J H ^a   Bringmann, G ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Biotransformation; Dioncophylline A; Malaria; Naphthylisoquinoline alkaloids

Indexed keywords

4 HYDROXYDIONCOPHYLLINE A; 5' O DEMETHYLDIONCOPHYLLINE A; ANTIMALARIAL AGENT; DIONCOPHYLLINE A; DRUG METABOLITE; ISOQUINOLINE ALKALOID; LIPID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOTRANSFORMATION; BODY WEIGHT; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STRUCTURE; IN VIVO STUDY; LIVER MICROSOME; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINALYSIS;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; ANTIMALARIALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; INJECTIONS, INTRAVENOUS; ISOQUINOLINES; KINETICS; MALE; MICROSOMES, LIVER; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLASMODIUM FALCIPARUM; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33748699324     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600805501     Document Type: Article

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