Genetic mechanisms for the synthesis of fucosyl GM1 in small cell lung cancer cell lines

Glycobiology

Volumn 16, Issue 10, 2006, Pages 916-925

  Tokuda, Noriyo ^a   Zhang, Qing ^a   Yoshida, Shoko ^a,b   Kusunoki, Susumu ^c   Urano, Takeshi ^a   Furukawa, Keiko ^a   Furukawa, Koichi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; COMPLEMENTARY DNA; FUCOSYLGANGLIOSIDE GM1; FUCOSYLTRANSFERASE; GANGLIOSIDE; GANGLIOSIDE GD3; GLYCOSYLTRANSFERASE; MESSENGER RNA; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER THERAPY; CONTROLLED STUDY; FUCOSYLATION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPOGENESIS; LUNG SMALL CELL CANCER; PRIORITY JOURNAL;

BLOOD GROUP ANTIGENS; CARCINOMA, SMALL CELL; FUCOSE; FUCOSYLTRANSFERASES; G(M1) GANGLIOSIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MUTATION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 33748691364     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwl022     Document Type: Article

References (61)

1. Ariga, T., Macala, L.J., Saito, M., Margolis, R.K., Greene, L.A., Margolis, R.U., and Yu, R.K. (1988) Lipid composition of PC12 pheochromocytoma cells: Characterization of globoside as a major neutral glycolipid. Biochemistry, 27, 52-58.
2. Aubert, M., Panicot, L., Crotte, C., Gibier, P., Lombardo, D., Sadoulet, M.O., and Mas, E. (2000) Restoration of alpha(1,2) fucosyltransferase activity decreases adhesive and metastatic properties of human pancreatic cancer cells. Cancer Res., 60, 1449-1456.
3. Barreaud, J.P., Saunier, K., Souchaire, J., Delourme, D., Oulmouden, A., Oriol, R., Leveziel, H., Julien, R., and Petit, J.M. (2000) Three bovine alpha2-fucosyltransferase genes encode enzymes that preferentially transfer fucose on Ga1beta1-3Ga1NAc acceptor substrates. Glycobiology, 10, 611-621.
4. Brezicka, T., Bergman, B., Olling, S., and Fredman, P. (2000) Reactivity of monoclonal antibodies with ganglioside antigens in human small cell lung cancer tissues. Lung Cancer, 28, 29-36.
5. Brezicka, F., Holmgren, J., Kalies, I., and Lindholm, L. (1991) Tumor-cell killing by Mabs against fucosyl GM1, a ganglioside antigen associated with small-cell lung carcinoma. Int. J. Cancer, 49, 911-918.
6. Brezicka, F.T., Olling, S., Nilsson, O., Bergh, J., Holmgren, J., Sorenson, S., Yngvason, F., and Lindholm, L. (1989) Immunohistological detection of fucosyl-GM1 ganglioside in human lung cancer and normal tissues with monoclonal antibodies. Cancer Res., 49, 1300-1305.
7. Carubia, J.M., Yu, R.K., Macala, L.J., Kirkwood, J.M., and Varga, J.M. (1984) Gangliosides of normal and neoplastic human melanocytes. Biochem. Biophys. Res. Commun., 120, 500-504.
8. Cheung, N.K., Saarinen, U.M., Neely, J.E., Landmeier, B., Donovan, D., and Coccia, P.F. (1985) Monoclonal antibodies to a glycolipid antigen on human neuroblastoma cells. Cancer Res., 45, 2642-2649.
9. Clausen, H. and Hakomori, S. (1989) ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution. Vox Sang., 56, 1-20.
10. Dickler, M.N., Ragupathi, G., Liu, N.X., Musselli, C., Martino, D.J., Miller, V.A., Kris, M.G., Brezicka, F.T., Livingston, P.O., and Grant, S.C. (1999) Immunogenicity of a fucosyl-GM1-keyhole limpet hemocyanin conjugate vaccine in patients with small cell lung cancer. Clin. Cancer Res., 5, 2773-2779.
11. Domino, S.E., Zhang, L., Gillespie, P.J., Saunders, T.L., and Lowe, J.B. (2001) Deficiency of reproductive tract α(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2α (1,2)fucosyltransferase locus. Mol. Cell. Biol., 21, 8336-8345.
12. Ferrari, G., Anderson, B.L., Stephens, R.M., Kaplan, D.R., and Greene, L.A. (1995) Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors. J. Biol. Chem., 270, 3074-3080.
13. Fredman, P., von Holst, H., Collins, V.P., Ammar, A., Dellheden, B., Wahren, B., Granholm, L., and Svennerholm, L. (1986) Potential ganglioside antigens associated with human gliomas. Neurol. Res., 8, 123-126.
14. Fukumoto, S., Mutoh, T., Hasegawa, T., Miyazaki, H., Okada, M., Goto, G., Furukawa, K., and Urano, T. (2000) GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation. J. Biol. Chem., 275, 5832-5838.
15. Goupille, C., Marionneau, S., Bureau, V., Hallouin, F., Meichenin, M., Rocher, J., and Le Pendu, J. (2000) α1,2Fucosyltransferase increases resistance to apoptosis of rat colon carcinoma cells. Glycobiology, 10, 375-382.
16. Hallouin, F., Goupille, C., Bureau, V., Meflah, K., and Le Pendu, J. (1999) Increased tumorigenicity of rat colon carcinoma cells after α1,2-fucosyltransferase FTA anti-sense cDNA transfection. Int. J. Cancer, 80, 606-611.
17. Hamamura, K., Furukawa, K., Hayashi, T., Hattori, T., Nakano, J., Nakashima, H., Okuda, T., Mizutani, H., Hattori, H., Ueda, M., and others. (2005) Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. Proc. Natl. Acad. Sci. U. S. A., 102, 11041-11046.
18. Henry, S., Mollicone, R., Fernandez, P., Samuelsson, B., Oriol, R., and Larson, G. (1996a) Homozygous expression of a missense mutation at nucleotide, 385 in the FUT2 gene associates with the Le (a+b+) partial-secretor phenotype in an Indonesian family. Biochem. Biophys. Res. Commun., 219, 675-678.
19. Henry, S., Mollicone, R., Fernandez, P., Samuelsson, B., Oriol, R., and Larson, G. (1996b) Morecular basis for erythrocyte Le (a+b+) and salivary ABH partial-escretor phenotypes: Expression of a FUT2 secretor allele with an A→T mutation at nucreotide, 385 correlated with reduced alpha (1,2) fucosyltransferase activity. Glycoconj. J., 13, 985-993.
20. Henry, S., Mollicone, R., Low, J.B., Samuelsson, B., and Larson, G. (1996c) A second nonsecretor allele of the blood group a (1,2) fucosyltransferase gene (FUT2). Vox Sang., 70, 21-25.
21. Houghton, A.N., Mintzer, D., Cordon-Cardo, C., Welt, S., Fliegel, B., Vadhan, S., Carswell, E., Melamed, M.R., Oettgen, H.F., and Old, L.J. (1985) Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: A phase I trial in patients with malignant melanoma. Proc. Natl. Acad. Sci. U. S. A., 82, 1242-1246.
22. Iwamori, M. and Domino, S.E. (2004) Tissue-specific loss of fucosylated glycolipids in mice with targeted deletion of α (1,2) fucosyltransferase genes. Biochem. J., 380, 75-81.
23. Ju, T. and Cummings, R.D. (2002) A unique molecular chaperone Cosmc required for activity of the mammalian core, 1 β3-galactosyltransferase. Proc. Natl. Acad. Sci. U. S. A., 99, 16613-16618.
24. Kaneko, M., Nishihara, S., Shinya, N., Kudo, T., Iwasaki, H., Seno, T., Okubo, Y., and Narimatsu, H. (1997) Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme. Blood, 90, 839-849.
25. Kelly, R.J., Rouquier, S., Giorgi, D., Lennon, G.G., and Lowe, J.B. (1995) Sequence and expression of a candidate for the human secretor blood group α (1,2) fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J. Biol. Chem., 270, 4640-4649.
26. Klenk, E. (1942) Uber die ganglioside, eine neue gruppe von zuckerhaltigen gehirnlipoiden. Hoppe-Seyler's Z. Physiol. Chem., 273, 76-86.
27. Koda, Y., Soejima, M., and Kimura, H. (2001) The polymorphisms of fucosyltransferases. Legal Med., 3, 2-14.
28. Koda, Y., Soejima, M., Liu, Y., and Kimura, H. (1996) Molecular basis for secretor type α(1,2)-fucosyltransferase gene deficiency in a Japanese population: A fusion gene generated by unequal crossover responsible for the enzyme deficiency. Am. J. Hum. Genet., 59, 343-350.
29. Koda, Y., Soejima, M., Wang, B., and Kimura, H. (1997) Structure and expression of the gene encoding secretor-type galactoside, 2-α-L-fucosyltransferase (FUT2). Eur. J. Biochem., 246, 750-755.
30. Kosugi, S., Akamizu, T., Miyamoto, M., Sugawa, H., Iwamori, M., Nagai, Y., Mori, T., and Imura, H. (1987) Biological effect of anti-fucosyl GM1 ganglioside antibody on cyclic adenosine, 3!,5!-monophosphate production in FRTL5 rat thyroid cells. Biochem. Biophys. Res. Commun., 143, 848-855.
31. Krug, L.M., Ragupathi, G., Hood, C., Kris, M.G., Miller, V.A., Allen, J.R., Keding, S.J., Danishefsky, S.J., Gomez, J., Tyson, L., and others (2004) Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin. Clin. Cancer Res., 10, 6094-6100.
32. Kudo, T., Iwasaki, H., Nishihara, S., Shinya, N., Ando, T., Nariamtsu, I., and Narimatsu, H. (1996) Molecular genetic analysis of the human Lewis histo-blood group system II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals. J. Biol. Chem., 271, 9830-9837.
33. Kusunoki, S., Chiba, A., Shimizu, T., and Kanazawa, I. (1994) Unique localization of fucosyl GM1 in rabbit spinal cord and peripheral nerve: immunohistochemical study using monoclonal anti-fucosyl GM1 antibody CRD73-6. Biochem. Biophys. Acta, 1214, 27-31.
34. Kusunoki, S. and Inoue, K. (1991) Fucosylated glycoconjugates in human dorsal root ganglion cells with unmyelinated axons. Neurosci. Lett., 126, 159-162.
35. Kusunoki, S., Inoue, K., Iwamori, M., Nagai, Y., Mannen, T., and Kanazawa, I. (1992) Developmental changes of fucosylated glycoconjugates in rabbit dorsal root ganglia. Neurosci. Res., 15, 74-80.
36. Larsen, R.D., Ernst, L.K., Nair, R.P., and Lowe, J.B. (1990) Molecular cloning sequence, and expression of a human GDP-L-fucose: β-D-galactoside, 2-α-L-fucosyltransferase cDNA that can form the H blood group antigen. Proc. Natl. Acad. Sci. U. S. A., 87, 6674-6678.
37. Liu, Y.H., Koda, Y., Soejima, M., Pang, H., Wang, B.J., Kim, D.S., Oh, H.B., and Kimura, H. (1999) The fusion gene at the ABO-secretor locus (FUT2): Absence in Chinese populations. J. Hum. Genet., 44, 181-184.
38. Livingston, P.O., Hood, C., Krug, L.M., Warren, N., Kris, M.G., Brezicka, T., and Ragupathi, G. (2005) Selection of GM2, fucosyl GM1, globo H and polysialic acid as targets on small cell lung cancers for antibody mediated immunotherapy. Cancer Immunol. Immunother., 54, 1018-1025.
39. Lofling, J.C., Hauzenberger, E., and Holgersson, J. (2002) Absorption of anti-blood group A antibodies on P-selectin glycoprotein ligand-1/ immunoglobulin chimeras carrying blood group A determinants: Core saccharide chain specificity of the Se and H gene encoded α1,2 fucosyltransferases in different host cells. Glycobiology, 12, 173-182.
40. Lopez-Ferrer, A. and de Bolos, C. (2002) The expression of human FUT in HT-29/M3 colon cancer cells instruct the glycosylation of MUC1 an MUC5AC apomucins. Glycoconj. J., 19, 13-21.
41. Mas, E., Pasqualini, E., Caillol, N., El Battari, A., Crotte, C., Lombardo, D., and Sadoulet, M.O. (1998) Fucosyltransferase activities in human pancreatic tissue: Comparative study between cancer tissues and established tumoral cell lines. Glycobiology, 8, 605-613.
42. Mathieu, S., Prorok, M., Benoliel, A.M., Uch, R., Langlet, C., Bongrand, P., Gerolami, R., and El-Battari, A. (2004) Transgene expression of α(1,2)-fucosyltransferase-1 (FUT1) in tumor cells selectively inhibits sialyl-Lewis x expression and binding to E-selectin without affecting synthesis of sialyl-Lewis a or binding to P-selectin. Am. J. Pathol., 164, 371-383.
43. Miyazaki, H., Fukumoto, S., Okada, M., Hasegawa, T., and Furukawa, K. (1997) Expression cloning of rat cDNA encoding UDP-galactose: GD2 beta1,3-galactosyltransferase that determines the expression of GD1b/GM1/ GA1. J. Biol. Chem., 272, 24794-24799.
44. Mutoh, T., Tokuda, A., Miyadai, T., Hamaguchi, M., and Fujiki, N. (1995) Ganglioside GM1 binds to the Trk protein and regulates receptor function. Proc. Natl. Acad. Sci. U. S. A., 92, 5087-5091.
45. Narimatsu, H., Iwasaki, H., Nakayama, F., Ikehara, Y., Kudo, T., Nishihara, S., Sugano, K., Okura, H., Fujita, S., and Hirihashi, S. (1998) Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res., 58, 512-518.
46. Nilsson, O., Brezicka, F.T., Holmgren, J., Sorenson, S., Svennerholm, L., Yngvason, F., and Lindholm, L. (1986) Detection of a ganglioside antigen associated with small cell lung carcinomas using monoclonal antibodies directed against fucosyl-GM1. Cancer Res., 46, 1403-1407.
47. Nishio, M., Fukumoto, S., Furukawa, K., Ichimura, A., Miyazaki, H., Kusunoki, S., Urano, T., and Furukawa, K. (2004) Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells. J. Biol. Chem., 279, 33368-33378.
48. Okamura, A., Yazawa, S., Morinaga, N., Asao, T., and Kuwano, H. (2002) Increased thermosensitivity of mouse colorectal carcinoma cells transfected with human FUT1 gene. Cancer Lett., 180, 203-210.
49. Portoukalian, J., Zwingelstein, G., Dore, J.F., and Bourgoin, J.J. (1976) Studies of a ganglioside fraction extracted from human malignant melanoma. Biochimie, 58, 1285-1287.
50. Sarnesto, A., Kohlin, T., Thurin, J., and Blaszczyk-Thurin, M. (1990) Purification of H gene-encoded beta-galactoside alpha, 1→2 fucosyltransferase from human serum. J. Biol. Chem., 265, 15067-15075.
51. Sherwood, A.L., Stroud, M.R., Levery, S.B., and Holmes, E.H. (2001) An amino acid region at the N-terminus of rat hepatoma alpha1→2 fucosyltransferase modulates enzyme activity and interaction with lipids: Strong preference for glycosphingolipids containing terminal Ga1beta1→3Ga1NAc-structures. Biochemistry, 40, 5708-5719.
52. Suchy, S.F., Yamamoto, M., Barbero, L., and Schwarting, G.A. (1988) A monoclonal antibody, WCC4, recognizes a developmentally regulated ganglioside containing alpha-galactose and alpha-fucose present in the rat nervous system. Brain Res., 440, 25-34.
53. Vangsted, A., Drivsholm, L., Andersen, E., Pallesen, T., Zeuthen, J., and Wallin, H. (1994) New serum markers for small-cell lung cancer. I. The ganglioside fucosyl-GM1. Cancer Detect. Prev., 18, 221-229.
54. Wiegandt, H. (1985) Gangliosides. In Wiegandt, H. (ed.), Glycolipid. Elsevier Science Publishers B. V., New York, pp. 199-247.
55. Yamashiro, S., Ruan, S., Furukawa, K., Tai, T., Lloyd, K.O., Shiku, H., and Furukawa, K. (1993) Genetic and enzymatic basis for the differential expression of GM2 and GD2 gangliosides in human cancer cell lines. Cancer Res., 53, 5395-5400.
56. Yoshida, S., Fukumoto, S., Kawaguchi, H., Sato, S., Ueda, R., and Furukawa, K. (2001) Ganglioside G (D2) in small cell lung cancer cell lines: Enhancement of cell proliferation and mediation of apoptosis. Cancer Res., 61, 4244-4252.
57. Yoshino, H., Ariga, T., Latov, N., Miyatake, T., Kushi, Y., Kasama, T., Handa, S., and Yu, R.K. (1993) Fucosyl-GM1 in human sensory nervous tissue is a target antigen in patients with autoimmune neuropathies. J. Neurochem., 61, 658-663.
58. Yu, L.C., Broadberry, R.E., Yang, Y.H., Chen, Y.H., and Lin, M. (1996) Heterogeneity of the human Secretor α(1,2) fucosyltransferase gene among Lewis (a+b;) non-secretors. Biochem. Biophys. Res. Commun., 222, 390-394.
59. Yu, L.C., Lee, H.L., Chu, C.C., Broadberry, R.E., and Lin, M. (1999) A newly identified nonsecretor allel of the human histo-blood group a(1,2) fucosyltransferase gene (FUT2). Vox Sang., 76, 115-119.
60. Yuki, N. and Ariga, T. (1997) Antibodies to fucogangliosides in neurological diseases. J. Neurol. Sci., 150, 81-84.
61. Zhang, S., Cordon-Cardo, C., Zhang, H.S., Reuter, V.E., Adluri, S., Hamilton, W.B., Lloyd, K.O., and Livingston, P.O. (1997) Selection of tumor antigens as targets for immune attack using immunohistochemistry: I. Focus on gangliosides. Int. J. Cancer, 73, 42-49.