The fusion gene at the ABO-secretor locus (FUT2): Absence in Chinese populations

Journal of Human Genetics

Volumn 44, Issue 3, 1999, Pages 181-184

  Liu, Yu Hua ^a,b   Koda, Yoshiro ^a   Soejima, Mikiko ^a   Pang, Hao ^a,b   Wang, Bao Jie ^b   Kim, Doo Sung ^c   Oh, Heung Bum ^c   Kimura, Hiroshi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c Korean Red Cross   (South Korea)

Author keywords

ABO; Fusion gene; FUT2; Japanese; Secretor

Indexed keywords

FUCOSYLTRANSFERASE;

ALLELE; ARTICLE; BLOOD GROUP ABO SYSTEM; BLOOD GROUP LEWIS SYSTEM; CHINESE; CONTROLLED STUDY; DNA SEQUENCE; ETHNIC GROUP; FUSION GENE; GENE FREQUENCY; GENE LOCUS; HETEROZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; JAPAN; NONSENSE MUTATION; NORMAL HUMAN; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SOUTH KOREA;

EID: 0032944671     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380050138     Document Type: Article

References (16)

1. Hammer MF, Horai S (1995) Y chromosomal DNA variation and the peopling of Japan. Am J Hum Genet 56: 951-962
2. Hammer MF, Spurdle AB, Karafet T, Bonner MR, Wood ET, Novelletto A, Malaspina P, Mitchell RJ, Horai S, Jenkins T, Zegura SL (1997) The geographic distribution of human Y chromosome variation. Genetics 145: 787-806
3. Hanihara K (1991) Dual structure model for the population history of the Japanese. Japan Review 2: 1-33
4. Horai S, Murayama K, Hayasaka K, Matsubayashi S, Hattori Y, Fucharoen G, Harihara S, Park K-S, Omoto K, Pan I-H (1996) mtDNA polymorphism in East Asian populations, with special reference to the peopling of Japan. Am J Hum Genet 59: 579-590
5. Kamatani N, Terai C, Kim S-Y, Chen C-L, Yamanaka H, Hakoda M, Totokawa S, Kashiwazaki S (1996) The origin of the most common mutation of adenine phosphoribosyltransferase among Japanese goes back to a prehistoric era. Hum Genet 98: 596-699
6. Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB (1995) Sequence and expression of a candidate for the human secretor blood group α (1, 2)-fucosyltransferase gene (FUT2): homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J Biol Chem 270:4640-4649
7. Koda Y, Soejima M, Liu Y-H, Kimura H (1996) Molecular basis for secretor type α (1, 2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency. Am J Hum Genet 59: 343-350
8. Koda Y, Soejima M, Kimura H (1997a) Structure and expression of the gene encoding secretor-type galactoside 2-α-L-fucosyltransferase (FUT2). Eur J Biochem 246: 750-755
9. Koda Y, Soejima M, Johnson PH, Smart E, Kimura H (1997b) Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. Biochem Biophys Res Commum 238: 21-25
10. Liu Y-H, Koda Y, Soejima M, Pang H, Schlaphoff T, du Toit ED, Kimura H (1998) Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa. Hum Genet 103: 204-210
11. Liu Y-H, Koda Y, Soejima M, Pang H, Wang B-J, Kimura H (1999) Lewis (FUT3) genotypes in two different Chinese populations. J Forensic Sci 44: 82-86
12. Nakagome Y, Young S-R, Akane A, Numabe H, Jin D-K, Yamori Y, Seki S, Tamura T, Nagafuchi S, Shiono H, Nakahori Y (1992) A Y-associated allele may be characteristic of certain ethnic groups in Asia. Ann Hum Genet 56: 311-314
13. Narimatsu H, Iwasaki H, Nakayama F, Ikehara Y, Kudo T, Nishihara S, Sugano K, Okuda H, Fujita S, Hirohashi S (1998) Lewis and Secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res 58: 512-518
14. Nei M (1995) The origin of human populations: genetic, linguistic and archeological data. In: Brenner S, Hanihara K (eds) The origin and past of modern humans as viewed from DNA. World Scientific, Singapore, pp 71-91
15. Omoto K, Saitou N (1997) Genetic origin of the Japanese: a partial support for the dual structure hypothesis. Am J Phys Anthropol 102: 437-446
16. Yu L-C, Broadberry RE, Yang Y-H, Chen Y-H, Lin M (1996) Heterogeneity of the human secretor α (1, 2) fucosyltransferase gene among Lewis (a+b-) non-secretors. Biochem Biophys Res Commun 222: 390-394