Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria

Journal of Antimicrobial Chemotherapy

Volumn 58, Issue 4, 2006, Pages 768-772

  Hanoulle, Xavier ^a,c   Wieruszeski, Jean Michel ^a   Rousselot Pailley, Pierre ^a   Landrieu, Isabelle ^a   Locht, Camille ^b   LIppens, Guy ^a   Baulard, Alain R ^b  

^a UNIV LILLE   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

HRMAS NMR; Thioamide; Tuberculosis

Indexed keywords

BACTERIAL ENZYME; DRUG METABOLITE; ETHIONAMIDE; ISONIAZID; PRODRUG; PYRAZINAMIDE; PYRIDINE DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ARTICLE; BACTERIAL CELL; BACTERIAL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; DRUG ACCUMULATION; DRUG ACTIVATION; DRUG MECHANISM; DRUG METABOLISM; DRUG SELECTIVITY; ENZYME ACTIVATION; MEMBRANE PERMEABILITY; MULTIDRUG RESISTANCE; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUBERCULOSIS;

BACTERIAL PROTEINS; BIOTRANSFORMATION; CULTURE MEDIA; ETHIONAMIDE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MYCOBACTERIUM SMEGMATIS; OXYGENASES; PRODRUGS;

EID: 33748681705     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkl332     Document Type: Article

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