N-acetyl-D-glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichia coli

Journal of Bacteriology

Volumn 188, Issue 16, 2006, Pages 5851-5858

  Hirakawa, Hidetada ^a,b,c   Inazumi, Yoshihiko ^a,b   Senda, Yasuko ^a,b   Kobayashi, Asuka ^a,b   Hirata, Takahiro ^a,b   Nishino, Kunihiko ^a,b   Yamaguchi, Akihito ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CARRIER PROTEIN; CYCLIC AMP; CYCLIC AMP BINDING PROTEIN; GLUCOSAMINE; GLUCOSE; N ACETYLGLUCOSAMINE; PHOSPHOTRANSFERASE; PROTEIN MDTEF; UNCLASSIFIED DRUG; ESCHERICHIA COLI PROTEIN; EVGA PROTEIN, E COLI; EVGS PROTEIN, E COLI; GADX PROTEIN, E COLI; MEMBRANE PROTEIN; PROTEIN KINASE; SIGMA FACTOR; SIGMA FACTOR KATF PROTEIN, BACTERIA; TRANSCRIPTION FACTOR; YDEO PROTEIN, E COLI; YHIU PROTEIN, E COLI; YHIV PROTEIN, E COLI;

ARTICLE; BACTERIAL GENE; CATABOLITE ACTIVATION; CONTROLLED STUDY; CRP GENE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME REGULATION; ESCHERICHIA COLI; EVGSA GENE; GADX GENE; GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE INDUCTION; MDTEF GENE; NAGE GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS REGULATION; RPOS GENE; SIGNAL TRANSDUCTION; YDEO GENE; ANTIBIOTIC RESISTANCE; DRUG EFFECT; GENETICS; METABOLISM;

ESCHERICHIA COLI;

ACETYLGLUCOSAMINE; BACTERIAL PROTEINS; CYCLIC AMP RECEPTOR PROTEIN; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; PROTEIN KINASES; SIGMA FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 33748669657     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00301-06     Document Type: Article

References (33)

1. Álvarez-Añorve, L. I., M. L. Calcagno, and J. Plumbridge. 2005. Why does Escherichia coli grow more slowly on glucosamine than on N-acetylglucosamine? Effects of enzyme levels and allosteric activation of GlcN6P deaminase (NagB) on growth rates. J. Bacteriol. 187:2974-2982.
2. Barber, A. M., V. B. Zhurkin, and S. Adhya. 1993. CRP-binding sites: evidence for two structural classes with 6-bp and 8-bp spacers. Gene 130:1-8.
3. Elledge, S. J., and R. W. Davis. 1989. Position and density effects on repression by stationary and mobile DNA-binding proteins. Genes Dev. 3:185-197.
4. Gosset, G., Z. Zhang, S. Nayyar, W. A. Cuevas, and M. H. Saier, Jr. 2004. Transcriptome analysis of Crp-dependent catabolite control of gene expression in Escherichia coli. J. Bacteriol. 186:3516-3524.
5. Hirakawa, H., Y. Inazumi, T. Masaki, T. Hirata, and A. Yamaguchi. 2005. Indole induces the expression of multidrug exporter genes in Escherichia coli. Mol. Microbiol. 55:1113-1126.
6. Hirakawa, H., K. Nishino, T. Hirata, and A. Yamaguchi. 2003. Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J. Bacteriol. 185:1851-1856.
7. Hirakawa, H., K. Nishino, J. Yamada, T. Hirata, and A. Yamaguchi. 2003. β-Lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J. Antimicrob. Chemother. 52:576-582.
8. Jensen, K. F. 1993. The Escherichia coli K-12 "wild types" W3110 and MG1655 have an rph frameshift mutation that leads to pyrimidine starvation due to low pyrE expression levels. J. Bacteriol. 175:3401-3407.
9. Kimata, K., H. Takahashi, T. Inada, P. Postma, and H. Aiba. 1997. cAMP receptor protein-cAMP plays a crucial role in glucose-lactose diauxie by activating the major glucose transporter gene in Escherichia coli. Proc. Natl. Acad. Sci. USA 94:12914-12919.
10. Kobayashi, A., H. Hirakawa, T. Hirata, K. Nishino, and A. Yamaguchi. 2006. Growth phase-dependent expression of drug exporters in Escherichia coli and its contribution to drug tolerance. J. Bacteriol. 188:106-116.
11. Kotrba, P., M. Inui, and H. Yukawa. 2001. Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism. J. Biosci. Bioeng. 92:502-517.
12. Link, A. J., D. Phillips, and G. M. Church. 1997. Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization. J. Bacteriol. 179:6228-6237.
13. Ma, Z., N. Masuda, and J. W. Foster. 2004. Characterization of EvgAS-YdeO-GadE branched regulatory circuit governing glutamate-dependent acid resistance in Escherichia coli. J. Bacteriol. 186:7378-7389.
14. Masuda, N., and G. M. Church. 2003. Regulatory network of acid resistance genes in Escherichia coli. Mol. Microbiol. 48:699-712.
15. Miller, J. H. 1992. A short course in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor N.Y.
16. Morita, Y., K. Kodama, S. Shiota, T. Mine, A. Kataoka, T. Mizushima, and T. Tsuchiya. 1998. NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob. Agents Chemother. 42:1778-1782.
17. Nikaido, H. 1998. Multiple antibiotic resistance and efflux. Curr. Opin. Microbiol. 1:516-523.
18. Nishino, K., J. Yamada, H. Hirakawa, T. Hirata, and A. Yamaguchi. 2003. Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to β-lactams. Antimicrob. Agents Chemother. 47:3030-3033.
19. Nishino, K., and A. Yamaguchi. 2001. Analysis of a complete library of putative drug transporter genes in Escherichia coli. J. Bacteriol. 183:5803-5812.
20. Nishino, K., and A. Yamaguchi. 2002. EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli. J. Bacteriol. 184:2319-2323.
21. Nishino, K., and A. Yamaguchi. 2004. Role of histone-like protein H-NS in multidrug resistance of Escherichia coli. J. Bacteriol. 186:1423-1429.
22. Opdyke, J. A., J.-G. Kang, and G. Storz. 2004. GadY, a small-RNA regulator of acid response genes in Escherichia coli. J. Bacteriol. 186:6698-6705.
23. Plumbridge, J. 2001. DNA binding sites for the Mlc and NagC proteins: regulation of nagE, encoding the N-acetylglucosamine-specific transporter in Escherichia coli. Nucleic Acids Res. 29:506-514.
24. Plumbridge, J. A. 1990. Induction of the nag regulon of Escherichia coli by N-acetylglucosamine and glucosamine: role of the cyclic AMP-catabolite activator protein complex in expression of the regulon. J. Bacteriol. 172:2728-2735.
25. Plumbridge, J. A. 1991. Repression and induction of the nag regulon of Escherichia coli K-12: the roles of nagC and nagA in maintenance of the uninduced state. Mol. Microbiol. 5:2053-2062.
26. Poole, K. 2004. Efflux-mediated multiresistance in Gram-negative bacteria. Clin. Microbiol. Infect. 10:12-26.
27. Postma, P. W., J. W. Lengeler, and G. R. Jacobson. 1993. Phosphoenolpyruvate:carbonylhydrate phosphotransferase systems of bacteria. Microbiol. Mol. Biol. Rev. 57:543-594.
28. Sulavik, M. C., C. Houseweart, C. Cramer, N. Jiwani, N. Murgolo, J. Greene, B. DiDomenico, K. J. Shaw, G. H. Miller, R. Hare, and G. Shimer. 2001. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob. Agents Chemother. 45:1126-1136.
29. Taylor, J. W., J. Ott, and F. Eckstein. 1985. The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate- modified DNA. Nucleic Acids Res. 13:8765-8785.
30. Uehara, T., and J. T. Park. 2004. The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling. J. Bacteriol. 186:7273-7279.
31. van der Vlag, J., and P. W. Postma. 1995. Regulation of glycerol and maltose uptake by the 11AGlc-likc domain of I1Nag of the phosphotransferase system in Salmonella typhimurium LT2. Mol. Gen. Genet. 248:236-241.
32. Wang, L., Y. Hashimoto, C.-Y. Tsao, J. J. Valdes, and W. E. Bentley. 2005. Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli. J. Bacteriol. 187:2066-2076.
33. Wilson, D. O., P. Johnson, and B. R. McCord. 2001. Nonradiochemical DNase I footprinting by capillary electrophoresis. Electrophoresis 22:1979-1986.