New antifolate inhibitors for Mycobacterium avium

Medicinal Chemistry

Volumn 2, Issue 5, 2006, Pages 505-510

  Barrow, E W ^a   Suling, W J ^b   Seitz, L E ^b   Reynolds, R C ^b   Barrow, W W ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Antifolates; Deazapteridines; DFHR; IC50; In vitro; M. avium; M. tuberculosis; MIC

Indexed keywords

2,4 DIAMINO 5 METHYLDEAZAPTERIDINE DERIVATIVE; ANTIINFECTIVE AGENT; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; METHOTREXATE; RECOMBINANT ENZYME; SRI 20858; SRI 20903; SRI 20920; SRI 20923; SRI 20924; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; BACTERIUM ISOLATE; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PURIFICATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; NONHUMAN; PRIORITY JOURNAL; VALIDATION PROCESS;

ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; MOLECULAR STRUCTURE; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 33748648603     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340606778250225     Document Type: Article

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