Assessment of dosing impact on intra-individual variability in estimation of parameters for basic indirect response models

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 33, Issue 5, 2006, Pages 635-655

  Krzyzanski, Wojciech ^a   Dmochowski, Jacek ^b   Matsushima, Nobuko ^c   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Bias; Indirect response models; Intra individual variability; Parameter estimates; Pharmacodynamics; Precision

Indexed keywords

ACCURACY; ARTICLE; DOSE RESPONSE; DRUG DISPOSITION; DRUG DOSE REGIMEN; HISTOGRAM; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; SIMULATION;

BIOLOGICAL AVAILABILITY; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HUMANS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; OBSERVER VARIATION; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RESEARCH DESIGN; TIME FACTORS;

EID: 33748637113     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-006-9028-y     Document Type: Article

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