Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease

Molecular Immunology

Volumn 44, Issue 4, 2007, Pages 541-557

  Paley, Elena L ^a,b,c   Smelyanski, Larisa ^d   Malinovskii, Vladimir ^c   Subbarayan, Pochi R ^c   Berdichevsky, Yevgeny ^d   Posternak, Natalia ^d   Gershoni, Jonathan M ^d   Sokolova, Olga ^e   Denisova, Galina ^d,f  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Expert Medical Transcription Inc   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

^e BRANDEIS UNIVERSITY   (United States)

^f MCMASTER UNIVERSITY   (Canada)

Author keywords

Aggregation disaggregation; Alzheimer's disease; Aminoacyl tRNA synthetases; Epitope mapping; Monoclonal antibodies; Neuroblastoma; Pancreatic, cervical and kidney cancer cells

Indexed keywords

6C10 ANTIBODY; 9D7 ANTIBODY; AMIDE; ASPARTIC ACID; CARBOXYLIC ACID; EPITOPE; IMMUNOGLOBULIN G1 ANTIBODY; METHIONINE; MONOCLONAL ANTIBODY; MONOMER; OLIGOMER; RECOMBINANT ENZYME; SERINE; TRYPTOPHAN TRANSFER RNA LIGASE; TYROSINE; UNCLASSIFIED DRUG;

ALGORITHM; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; CANCER GROWTH; CONFORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DATA BASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FIBER; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PANCREAS CANCER; PHAGE DISPLAY; PREDICTION; PRIORITY JOURNAL; PURIFICATION; STATISTICAL SIGNIFICANCE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CATTLE; CELL LINE, TUMOR; CROSS REACTIONS; EPITOPE MAPPING; EPITOPES; HUMANS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROTEIN CONFORMATION; RABBITS; SPECIES SPECIFICITY; TRYPTOPHAN-TRNA LIGASE;

BOS TAURUS; MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33748632378     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.02.006     Document Type: Article

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