Comparison of the hemodynamic effects in acute intoxication with racemic bupivacaine and with 50% enantiomeric excess mixture (S75-R25). An experimental study in dogs;Comparação entre os efeitos hemodinâmicos da intoxicação aguda com bupivacaína racêmica e a mistura com excesso enatiomérico de 50% (S75-R25). Estudo experimental em cães

Revista Brasileira de Anestesiologia

Volumn 56, Issue 4, 2006, Pages 391-401

  Udelsmann, Artur ^a,b   Munhoz, Derli Conceição ^a   Silva, William Adalberto ^a   De Moraes, Ana Cristina ^a   Marcondes, Giancarlo ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b HC UNICAMP ^*  (Brazil)

Author keywords

Anesthetics, local: Racemic, bupivacaine, enantiomeric excess mixture; Animals: Dogs; Cardiovascular system: Hemodynamics alterations; Complications: Sistemic toxicity; Hemodynamic: Intoxication effects

Indexed keywords

BUPIVACAINE; PENTOBARBITAL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DOG; DRUG INTOXICATION; ENANTIOMER; FEMALE; HEART INDEX; HEART LEFT VENTRICLE WORK; HEMODYNAMICS; INTUBATION; MALE; NONHUMAN; RACEMIC MIXTURE; SWAN GANZ CATHETER;

EID: 33748578366     PISSN: 00347094     EISSN: 1806907X     Source Type: Journal    
DOI: 10.1590/S0034-70942006000400007     Document Type: Article

References (20)

1. Groban L, Deal DD, Vernon JC et al - Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg, 2001;92:37-43.
2. Chang DH, Ladd LA, Copeland S et al - Direct cardiac effects of intracoronary bupivacaine, levobupivaciane and ropivacaine in the sheep. Br J Pharmacol, 2001;132:649-658.
3. Albright GA - Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology, 1979;51:285-287.
4. Ohmura S, Kawada M, Ohta T et al - Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine, or ropivacaine-infused rats. Anesth Analg, 2001;93:743-748.
5. Aberg G - Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmacol Toxicol, 1972;31:273-286.
6. Luduena FP, Bogado EF, Tullar BF - Optical isomers of mepivacaine and bupivacaine. Arch Int Pharmacodyn, 1972;200:359-369.
7. Foster RH, Markham A - Levobupivacaine: a review of its pharmacology and use as a local anaesthetic. Drugs, 2000;59:551-579.
8. Bardsley H, Gristwood R, Baker H et al - A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers. Br J Clin Pharmacol, 1998;46:245-249.
9. st Ed, New York, Academic Press,1997;257-273.
10. st Ed, Philadelphia, WB Saunders, 1975;146.
11. rd ed, Philadelphia, Willians & Wilkins, 1996;426-447.
12. Delfino J, Vale NB - Bupivacaína levógira a 0,5% pura versus mistura enantiomérica de bupivacaína (S75-R25) a 0,5% em anestesia peridural para cirurgia de varizes. Rev Bras Anestesiol, 2001;51:474-481.
13. Tanaka PP, Souza RO, Salvalaggio MFO et al - Estudo comparativo entre bupivacaína a 0,5% e a mistura enantiomérica de bupivacaína (S75-R25) a 05% em anestesia peridural em pacientes submetidos a cirurgia ortopédica de membros inferiores. Rev Bras Anestesiol, 2003;53:331-337.
14. Gonçalves RF, Lauretti GR, Mattos Al - Estudo comparativo entre bupivacaína a 0,5% e mistura enantiomérica de bupivacaína (S75-R25) em anestesia peridural. Rev Bras Anestesiol, 2003;53:169-176.
15. Lacassie HJ, Columb MO - The relative motor blocking potencies of bupivacaine and levobupivacaine in labor. Anesth Analg, 2003;97:1509-1513.
16. Valenzuela C, Snyders DJ, Bennett PB et al - Stereosectivite block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. Circulation, 1995;92:3014-3024.
17. Royse CF, Royse AG - The myocardial and vascular effects of bupivacaine, levobupivacaine, and ropivacaine using pressure volume loops. Anesth Analg, 2005;101:679-687.
18. Masuda R, Takeda S, Yoshii S et al - Levobupivacaine exerts the most detrimental effect on the cardiovascular system among enantiomers of bupivacaína in anesthetized dogs. Anesthesiology, 2004;101:(Suppl):A652.
19. Jung CW, Lee KH, Choe YS et al - Comparison of resuscitative effect of insulin between bupivacaine and levobupivacaína induced cardiovascular collapse in dogs. Anesthesiology, 2004;101:(Suppl):A649.
20. Cox B, Durieux ME, Marcus MA - Toxicity of local anaesthetics. Best Pract Res Clin Anaesthesiol, 2003;17:111-136.