Establishment of long-term perfusion cultures of recombinant moss in a pilot tubular photobioreactor

Process Biochemistry

Volumn 41, Issue 10, 2006, Pages 2180-2187

  Lucumi, Alexander ^a   Posten, Clemens ^a  

^a UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Cross flow filtration (CFF); Perfusion culture; Physcomitrella patens; rhVEGF

Indexed keywords

BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE; GENETIC ENGINEERING; ROTORS;

CROSS-FLOW FILTRATION (CFF); PERFUSION CULTURE; PHYSCOMITRELLA PATENS;

PROTEINS;

BRYOPHYTA; PHYSCOMITRELLA; PHYSCOMITRELLA PATENS;

EID: 33748529252     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2006.06.017     Document Type: Article

References (32)

1. Schillberg S., Emans N., and Fischer R. Antibody molecular farming in plants and plant cells. Phytochem Rev 1 (2002) 45-54
2. Hohe A., and Reski R. From axenic spore germination to molecular farming. Plant Cell Rep 23 (2005) 513-521
3. Schaefer D. Gene targeting in Physcomitrella patens. Curr Opinion Plant Sci 4 (2001) 143-150
4. Schween G., Gorr G., Hohe A., and Reski R. Unique tissue-specific cell cycle in Physcomitrella. Plant Biol 5 (2003) 50-58
5. Schaefer D., and Zryd J.-P. The moss Physcomitrella patens, now and then. Plant Physiol 127 (2001) 1430-1438
6. Hohe A., and Reski R. Optimisation of a bioreactor culture of the moss Physcomitrella patens for mass production of protoplasts. Plant Sci 163 (2002) 69-74
7. Lucumi A., Fleck P., and Posten C. Scale-down of photobioreactors for moss cell suspension cultures. Proceedings of the first international congress on bioreactor technology in cell, tissue culture and biomedical applications (2003) 175-187
8. Garcia-Casado G., Sanchez-Monje R., Chrispeels M.J., Armentia A., Salcedo G., and Gomez L. Role of complex asparagine-linked glycans in the allergenicity of plant glycoproteins. Glyco-Biology 6 (1996) 471-477
9. Koprivova A., Stemmer C., Altmann F., Hoffmann A., Kopriva S., Gorr G., et al. Targeted knockouts of Physcomitrella patens lacking plant-specific immunogenic N-glycans. Plant Biotechnol J 2 (2004) 517-523
10. Huether C.M., Lienhart O., Baur A., Stemmer C., Gorr G., Reski R., et al. Glyco-engineering of moss lacking plant-specific sugar residues. Plant Biol 7 (2005) 292-299
11. Gorr G., and Wagner S. Humanized glycosylation: production of biopharmaceuticals in a moss bioreactor. Mod Biopharm 3 (2005) 919-930
12. Ferrara N., and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 18 (1997) 4-25
13. Baur A., Kaufmann F., Rolli H., Weise A., Luethje R., Berg B., et al. A fast and flexible PEG-mediated transient expression in plants for high level expression of secreted recombinant proteins. J Biotechnol 119 4 (2005) 332-342
14. Jost W., Link S., Horstmann V., Decker E., Reski R., and Gorr G. Isolation and characterisation of three moss derived beta-tubulin promoters suitable for recombinant expression. Curr Gene 47 (2005) 111-120
15. Baur A., Reski R., and Gorr G. Enhanced recovery of a secreted recombinant human growth factor using stabilizing additives and by co-expression of human serum albumin in the moss Physcomitrella patens. Plant Biotechnol J 3 (2005) 331-340
16. Knoop B. Development in bryophytes. In: Dyer A.F., and Duckett J.G. (Eds). The experimental biology of bryophytes (1984), Academic Press, London p. 143-76
17. Reski R. Development, genetics and molecular biology of mosses. Botanica Acta (1998) 1111-1115
18. Cove D.J., and Ashton N.W. The hormonal regulation of gametophytic development in bryophytes. In: Dyer A.F., and Duckett J.G. (Eds). The experimental biology of bryophytes (1984), Academic Press, London 177-196
19. Boyd P.J., Hall J., and Cove D. An airlift fermenter for the culture of the moss Physcomitrella patens. In: Glime J.M. (Ed). Methods in bryology, Proceedings of the Bryology Methods Workshop Mainz (1988), Hattori Bot Lab., Nichinan 41-45
20. Decker E., and Reski R. The moss bioreactor. Curr Opinion Plant Biol 7 (2004) 166-170
21. Gorr G. Biotechnologische Nutzung von Physcomitrella patens (hedw.) BSG. PhD thesis. University of Hamburg; 1999.
22. Perner I. Scale-down von photobioreaktoren. PhD thesis. University of Karlsruhe; 2003.
23. Lucumi A., Posten C., and Pons M.-N. Image analysis supported moss cell disruption in photobioreactors. Plant Biol 7 (2005) 276-282
24. Ramsay B., Ramsay J., De Tremblay M., and Chavarie C. A method for the quantification of bacterial protein in the presence of jarosite. Geomicrobiol J 6 3-4 (1988) 171-177
25. Su W., and Arias R. Continuous plant cell perfusion culture: bioreactor characterization and secreted enzyme production. J Biosci Bioeng 95 1 (2003) 13-20
26. Cho GH, Shin MG. Repub. Korean Kongkae Taeho Kongbo. High cell density cultivation method of plant cell using ultrasonic wave. Patent. KR 2001094111. 01.10.31.
27. Wagner R, Elsayed AE. GBF Gesellschaft fuer biotechnologische Forschung GmbH. Method, apparatus and system for separating eucaryotic or procaryotic cells or other particularly biological material from a suspension. Patent. WO 2004099362. 04.11.18.
28. Brahmbhatt H, Macdiarmid J. Engeneic Molecular Delivery Pty Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells. Patent. WO 2004113507. 04.12.29.
29. Haarstrick A., Rau U., and Wagner F. Cross-flow filtration as a method of separating fungal cells and purifying the polysaccharide produced. Bioprocess Eng 6 4 (1991) 179-186
30. Vandanjon L., Rossignol N., Jaouen P., Roberts J.M., and Quemeneur F. Effects of shear on two microalgae species contribution of pumps and valves in tangential flow filtration systems. Biotechnol Bioeng 63 (1999) 1-9
31. Hohe A., Schween G., and Reski R. Establishment of a semicontinous bioreactor culture of Physcomitrella patens for mass production of protoplast. Acta Horticult 560 (2001) 425-428
32. Hohe A., Decker E.L., Gorr G., Schween G., and Reski R. Tight control of growth and cell differentiation in photoautotrophically growing moss (Physcomitrella patens) bioreactor cultures. Plant Cell Rep 20 (2002) 1135-1140