The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs

Medical Immunology

Volumn 5, Issue , 2006, Pages

  Smith, Kendall A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D1; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 9 RECEPTOR; JANUS KINASE; JANUS KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; STAT PROTEIN INHIBITOR; STAT3 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; UNCLASSIFIED DRUG;

ALPHA CHAIN; ALPHA HELIX; BETA CHAIN; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CD8+ T LYMPHOCYTE; COMBINED IMMUNODEFICIENCY; COMPLEX FORMATION; CRYSTALLIZATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG METABOLISM; HUMAN; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; T LYMPHOCYTE ACTIVATION;

EID: 33748500819     PISSN: 14769433     EISSN: 14769433     Source Type: Journal    
DOI: 10.1186/1476-9433-5-3     Document Type: Review

References (44)

1. Robb RJ, Smith KA: Heterogeneity of human T-cell growth factor(s) due to variable glycosylation. Mol Immunol 1981, 18:1087-1094.
2. Smith KA, Favata MF, Oroszlan S: Production and characterization of monoclonal antibodies to human intereukin 2: strategy and tactics. J Immunol 1983, 131:1808-1815.
3. Robb RJ, Munck A, Smith KA: T cell growth factor receptors. Quantitation, specificity, and biological relevance. J Exp Med 1981, 154:1455-1474.
4. Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC: A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature 1982, 300:267-269.
5. Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ: Novel interleukin-2 receptor subunit detected by cross-linking under high affinity conditions. Science 1986, 234:859-863.
6. Teshigawara K, Wang HM, Kato K, Smith KA: Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med 1987, 165:223-238.
7. Tsudo M, Kozak RW, Goldman CK, Waldmann TA; Contribution of a p75 interleukin 2 binding peptide to a high-affinity interleukin 2 receptor complex. Proc Natl Acad Sci USA 1987, 84:4215-4218.
8. Takeshita T, Ohtani K, Asao H, Kumaki S, Nakamura M, Sugamura K: An associated molecule, p64, with IL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex. J Immunol 1992, 148:2154-2158.
9. Lambert G, Stura EA, Wilson IA: Crystallization and preliminary X-ray diffraction studies of a complex between interleukin-2 and a soluble form of the p55 component of the high affinity interleukin-2 receptor. J Biol Chem 1989, 264:12730-12736.
10. Wang X, Rickert M, Garcia KC: Structure of the Quaternary Complex of Interleukin-2 with Its {alpha}, {beta}, and {gamma}c Receptors. Science 2005, 310: 1159-1163.
11. Stauber D, Debler E, Horton P, Smith K, Wilson I: Crystal structure of the interleukin-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci USA 2005 in press.
12. Bazan JF: Unraveling the structure of IL2. Science 1992, 257:410-413.
13. Langley J: On the physiology of the salivary secretion. J Physiol (Lond) 1878, 1:339-369.
14. Langley J: On the reaction of cells and nerve endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari. J Physiol (Lond) 1905, 33:374-413.
15. Wang HM, Smith KA: The interleukin 2 receptor. Functional consequences of its bimolecular structure. J Exp Med 1987, 166:1055-1069.
16. Johnson K, Choi Y, Wu Z, Ciardelli T, Granzow R, Whalen C, Sana T, Pardee G, Smith K, Creasy A: Soluble IL2 receptor beta and gamma subunits: ligand binding and cooperativity. Eur Cytokine Netw 1994, 5:23-34.
17. Nelson B, Lord J, Greenberg P: Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation. Nature 1994, 369:333-336.
18. Russell S, Johnston J, Noguchi M, Kawamura M, Witthuhn B, Silvennoinen O, Goldman A, Schmalsteig F, Ihle J, O'Shea J, Leonard W: Interaction of IL2R beta and gamma-c chains with JAK1 and JAK3: implications for XSCID and XCID. Science 1994, 266:1042-1045.
19. Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Nakamura M, Takeshita T: The common gamma chain for multiple cytokine receptors. Adv Immunol 1995, 59:225-277.
20. Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K. Cutting Edge: The Common {{gamma}}-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex. J Immunol 2001, 167:1-5.
21. Lin J-X, Migone T-S, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, et al.: The role of shared receptor motifs and common Stat proteins in the generation of cytokine plietropy and redundancy by IL2, IL4, IL7, IL13, and IL15. Immunity 1995, 2:331-339.
22. Sana T, Wu Z, Smith K, Ciardelli T: Expression and ligand binding characterization of the beta subunit(p75) ectodomain of the interleukin-2 receptor. Biochem 1994, 33:5838-5845.
23. Wu Z, Johnson KW, Goldstein B, Choi Y, Eaton SF, Laue TM, Ciardelli TL: Solution Assembly of a Soluble, Heteromeric, High Affinity Interleukin-2 Receptor Complex. J Biot Chem 1995, 270:16039-16044.
24. Wu Z, Johnson KW, Choi Y, Ciardelli TL: Ligand Binding Analysis of Soluble Interleukin-2 Receptor Complexes by Surface Plasmon Resonance. J Biol Chem 1995, 270:16045-16051.
25. Wu Z, Goldstein B, Laue TM, Liparoto S, Nemeth M, Ciardelli T: Solution assembly of the pseudo-high affinity and intermediate affinity interleukin-2 receptor complexes. Protein Sci 1999, 8:482-489.
26. Liparoto S, Ciardelli T. Biosensor analysis of the interleukin-2 receptor complex. J Mol Rec 1999, 12:316-321.
27. Liparoto SF, Myszka DG, Wu Z, Goldstein B, Laue TM, Ciardelli TL: Analysis of the Role of the Interleukin-2 Receptor Gamma Chain in Ligand Binding. Biochemistry 2002, 41:2543-2551.
28. Smith KA: Cantrell DA: Interleukin 2 regulates its own receptors. Proc Natl Acad Sci USA 1985, 82:864-868.
29. Smith KA: The interleukin 2 receptor. Annu Rev Cell Biol 1989, 5:397-425.
30. Cantrell DA, Smith KA. The interleukin-2 T-cell system: a new cell growth model. Science 1984, 224:1312-1316.
31. Smith K: The quantal theory of how the immune system discriminates between "self and non-self" Med Immunol 2004, 3:3.
32. Smith K: The quantal theory of immunity. Cell Res 2006, 16:11-19.
33. Rickert M, Boulanger M, Goriatcheva N, Garcia K: Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin 2 and its alpha, beta and gamma receptors. J Mol Biol 2004, 339:1115-1128.
34. Rickert M, Wang X, Boulanger M, Goriatcheva N, Garcia K: The structure of interleukin-2 complexed with its alpha receptor. Science 2005, 308:1477-1480.
35. Ku C, Murakami M. Sakamoto A, Kappler J, Marrack P: Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 2000, 288:675-678.
36. Boyman O, Kovar M, Rubinstein M, Surh C, Sprent J: Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 2006, 311:1924-1927.
37. Smith K: Interleukin 2 Immunotherapy. In Therapeutic Immunology 2nd edition. Edited by: Austen F, Burakoff S, Rosen F, Strom T. Malden MA: Blackwell Science, Inc.; 2001:240-250.
38. Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, et al: Stat5a/b, are essential for normal lymphoid development and differentiation. PNAS 2006, 103:1000-1005.
39. Hoelbl A, Kovacic B, Kerenyi MA, Simma O, Warsch W, Cui Y, Beug H, Hennighausen L, Moriggl R, Sexl V: Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood 2006, 107:4898-4906.
40. Zmuidzinas A, Mamon HJ, Roberts TM, Smith KA: Interleukin 2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G 1 and S in CD3-stimulated primary human T cells. Mol Cell Bio 1991, 11:2794-2803.
41. Moon J, Rubio E, Martino A, Krumm A, Nelson B: A permissive role for phophatidylinositol 3-kinase in the STAT5-mediated expression of cyclin D2 by the interleukin-2 receptor J Biol Chem 2004, 279:5520-5527.
42. Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, et al: Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 1999, 10:249-259.
43. Moriggl R, Sexl V, Piekorz R, Topham D, Ihle J: Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 1999, 11:225-230.
44. Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim Y, Paz K, Darnell J, Albanese C, et al: Cyclin D 1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res 2006, 66:2544-2552.