Insight in first-episode psychosis

Psychological Medicine

Volumn 36, Issue 10, 2006, Pages 1385-1393

  McEvoy, Joseph P ^a   Johnson, Jackie ^b,c   Perkins, Diana ^b   Lieberman, Jeffrey A ^d   Hamer, Robert M ^b,c   Keefe, Richard S E ^a   Tohen, Mauricio ^e   Glick, Ira D ^f   Sharma, Tonmoy ^g  

^a John Umstead Hospital   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c IL   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e ELI LILLY AND COMPANY   (United States)

^f STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^g NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE;

ADOLESCENT; ADULT; ARTICLE; BRAIN SIZE; CLINICAL TRIAL; COGNITION; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; ETHNOLOGY; FEMALE; HUMAN; INTROSPECTION; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PATIENT COMPLIANCE; POSITIVE AND NEGATIVE SYNDROME SCALE; PROBABILITY; PSYCHOSIS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SCORING SYSTEM;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; ATTITUDE TO HEALTH; BENZODIAZEPINES; BRAIN; COGNITION DISORDERS; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; FEMALE; HALOPERIDOL; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHOTIC DISORDERS; QUESTIONNAIRES; TREATMENT REFUSAL;

EID: 33748498457     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291706007793     Document Type: Article

References (51)

1. Amador, X. F., Andreasen, N. C., Flaum, M., Strauss, D. H., Yale, S. A. & Clark, S. (1994). Awareness of illness in schizophrenia, schizoaffective and mood disorders. Archives of General Psychiatry 51, 826-836.
2. Amador, X. F. & David, A. S. (2004). Insight and Psychosis (2nd edn). Oxford University Press: New York.
3. Cassidy, F., McEvoy, J. P., Yang, Y. K. & Wilson, W. H. (2001). Insight is greater in mixed than in pure manic episodes of bipolar I disorder. Journal of Nervous and Mental Disease 189, 398-399.
4. Coldham, E., Addington, J. & Addington, D. (2002). Medication adherence of individual with a first episode of psychosis. Acta Psychiatrica Scandinavica 106, 286-290.
5. Collins, A., Remington, G., Coulter, C. & Birkett, D. (1997). Insight, neurocognitive function and symptom clusters in chronic schizophrenia. Schizophrenia Research 27, 37-44.
6. Cuesta, M. & Peralta, V. (1994). Lack of insight in schizophrenia. Schizophrenia Bulletin 202, 359-366.
7. Cuesta, M., Peralta, V., Carlo, F. & de Leon, J. (1995). Is poor insight in psychotic disorders associated with poor performance on the Wisconsin Card Sorting Test? American Journal of Psychiatry 152, 1380-1382.
8. David, A., van Os, J. V., Jones, P., Harvey, I., Foerster, A. & Fahy, T. (1995). Insight and psychotic illness: Cross-sectional and longitudinal associations. British Journal of Psychiatry 167, 621-628.
9. Dickerson, F., Boronow, J., Ringel, N. & Parente, F. (1977). Lack of insight among outpatients with schizophrenia. Psychiatric Services 48, 195-199.
10. Dickerson, F., Boronow, J., Ringel, N. & Parente, F. (1996). Neurocognitive deficits and social functioning in outpatients with schizophrenia. Schizophrenia Research 21, 75-83.
11. Drake, R., Pickles, A., Bentall, R., Kinderman, P., Haddock, G., Tarrier, N. & Lewis, S. (2004). The evolution of insight, paranoia and depression during early schizophrenia. Psychological Medicine 34, 285-292.
12. Fennig, S. H., Everett, E., Bromet, E., Jandorf, L., Fennig, S. I., Tanenberg-Karant, M. & Craig, T. (1996). Insight in first admission psychotic patients. Schizophrenia Research 22, 257-263.
13. Fennig, S. H., Rabinowitz, J. & Fennig, S. I. (1999). Involuntary first admission of patients with schizophrenia as a predictor of future admissions. Psychiatric Services 59, 1049-1052.
14. Flashman, L., McAllister, T., Andreasen, N. & Saykin, A. (2000). Smaller brain size associated with unawareness of illness in patients with schizophrenia. American Journal of Psychiatry 157, 1167-1169.
15. Guy, W. (1976). Clinical Global Impressions (CGI). In Early Clinical Drug Evaluation Unit (ECDEU) Assessment Manual for Psychopharmacology, revised edition. US Department of Health, Education and Welfare: Washington, DC.
16. Johnson, S. K. & Orell, M. (1996). Insight psychosis and ethnicity: A case-note study. Psychological Medicine 26, 1081-1084.
17. Kay, S., Fishbein, A. & Opler, L. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261-275.
18. Keefe, R. S. E., Seidman, L. J., Christensen, B. K., Hamer, R. M., Sharma, T., Sitskoorn, M. M., Lewine, R. R. J., Yurgelun-Todd, D. A., Gur, R. C., Tohen, M., Tollefson, G. D., Sanger, T. M. & Lieberman, J. A. (2004). Comparative effect of atypical and conventional antipsychotic drugs on neurocognition in first-episode psychosis: A randomized, double-blind trial of olanzapine versus haloperidol. American Journal of Psychiatry 161, 985-995.
19. Keefe, R. S., Seidman, L. J., Christensen, B. K., Hamer, R. M., Sharma, T., Sitskoorn, M. M., Rock, S. L., Woolson, S., Tohen, M., Tollefson, G. D., Sanger, T. M. & Lieberman, J. A.; HGDH Research Group (2006). Long-term neurocognitive effects of olanzapine or low-dose haloperidol in first-episode psychosis. Biological Psychiatry 59, 97-105.
20. Kemp, R. & David, A. (1996). Psychological predictors of insight and compliance in psychotic patients. British Journal of Psychiatry 169, 444-450.
21. Kemp, R. & Lambert, T. (1995). Insight in schizophrenia and its relationship to psychopathology. Schizophrenia Research 18, 21-28.
22. Kirmayer, L. J., Corin, E. & Jarvis, G. E. (2004). Inside knowledge: cultural constructions of insight in psychosis. In Insight and Psychosis (2nd edn) (ed. X. F. Amador and A. S. David), pp. 197-229. Oxford University Press: New York.
23. Laroi, F., Fannemel, M., Ronneberg, U., Fickkoy, K., Opjordsmoen, S. & Dullcrud, R. & Haakonsen, M. (2000). Unawareness of illness in chronic schizophrenia and its relationship to structural brain measures and neuropsychological tests. Psychiatry Research 100, 49-58.
24. Lysaker, P. & Bell, M. (1994). Insight and cognitive impairment in schizophrenia: Performance on repeated administrations of the Wisconsin Card Sorting Test. Journal of Nervous and Mental Disease 182, 656-660.
25. Lieberman, J. A., Tollefson, G. D., Charles, C., Zipursky, R., Sharma, T., Kahn, R., Keefe, R. S. E., Green, A. I., Gur, R. E., McEvoy J. P., Perkins, D., Hamer, R. M., Gu, H. & Tohen, M.; HGDH Study Group (2005). Antipsychotic drug effects on brain morphology in first-episode psychosis. Archives of General Psychiatry 62, 361-370.
26. Lieberman, J. A., Tollefson, G. D., Tohen, M., Green, A. I., Gur, R. E., Kahn, R., McEvoy, J. P., Perkins, D., Sharma, T., Zipursky, R., Wei, H. & Hamer, R. M. (2003). Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: A randomized, double-blind trial of olanzapine versus haloperidol. American Journal of Psychiatry 160, 1396-1404.
27. Macpherson, R., Jerrom, B. & Hughes, A. (1996a). A controlled study of education about drug treatment in schizophrenia. British Journal of Psychiatry 168, 709-717.
28. Macpherson, R., Jerrom, B. & Hughes, A. (1996b). Relationship between insight, educational background and cognition in schizophrenia. British Journal of Psychiatry 168, 718-722.
29. Markova, I. S. & Berrios, G. E. (1992). The meaning of insight in clinical psychiatry. British Journal of Psychiatry 160, 850-860.
30. Marks, K., Fastenau, P., Lysaker, P. & Bond, G. (2000). Self-Appraisal of Illness Questionnaire (SAIQ): Relationship to researcher-rated insight and neuropsychological function in schizophrenia. Schizophrenia Research 45, 203-211.
31. McEvoy, J., Freter, S., Merritt, M. & Apperson, L. (1993). Insight about psychosis among outpatients and schizophrenia. Hospital Community 44, 883-884.
32. McEvoy, J., Hartmen, M., Gottlieb, D., Godwin, S., Apperson, L. & Wilson, W. (1996). Common sense, insight and neuropsychological test performance in schizophrenic patients. Schizophrenia Bulletin 22, 635-641.
33. McEvoy, J. P. (2004). The relationship between insight into psychosis and compliance with medication. In Insight and Psychosis (2nd edn) (ed. X. F. Amador and A. S. David), pp. 311-323. Oxford University Press: New York.
34. McEvoy, J. P., Apperson, L. J., Appelbaum, P. S., Ortlip, P., Brekosky, J., Hamill, K. & Roth, L. (1989). Insight in schizophrenia: Its relationship to acute psychopathology. Journal of Nervous and Mental Disease 177, 43-47.
35. Mohamed, S., Fleming, S., Penn, D. & Spaulding, W. (1999). Insight in schizophrenia: Its relationship to measures of executive functions. Journal of Nervous and Mental Disease 187, 525-531.
36. Montgomery, S. A. & Asberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry 134, 382-389.
37. Mutsatsa, S., Joyce, E., Hutton, S., Webb, E., Gibbons, H., Paul, S. & Barnes, T. (2003). Clinical correlates of early medication adherence: West London first episode schizophrenia study. Acta Psychiatrica Scandinavica 108, 439-446.
38. Novak-Grubic, V. & Tavcar, R. (1999). Treatment compliance in first-episode schizophrenia. Psychiatric Services 50, 970-971.
39. Perkins, D., Johnson, J., Hamer, R., Zipursky, R., Keefe, R., Centorrhino, F., Green, A., Glick, I., Kahn, R., Sharma, T., Tohen, M., McEvoy, J., Weiden, P. & Lieberman, J.; HDGH Research Group (2006). Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode. Schizophrenia Research 83, 57-63.
40. Perkins, R. E. & Moodley, P. (1993). Perception of problems in psychiatric inpatients: Denial, race, and service usage. Social Psychiatry and Psychiatric Epidemiology 28, 189-193.
41. Sanz, M., Constable, G., Lopez-Ibor, I., Kemp, R. & David, A. (1998). A comparative study of insight scales and their relationship to psychopathological and clinical variables. Psychological Medicine 28, 437-446.
42. Shad, M., Mudasani, S., Prasad, P., Sweeney, J. & Keshavan, M. (2004). Insight and prefrontal cortex in first-episode schizophrenia. Science Direct 22, 1315-1320.
43. Smith, T. E., Hull, J. W., Israel, L. M. & Willson, D. F. (2000). Insight, symptoms, and neurocognition in schizophrenia and schizoaffective disorder. Schizophrenia Bulletin 26, 193-200.
44. Startup, M. (1996). Insight and cognitive deficits in schizophrenia: evidence for a curvilinear relationship. Psychological Medicine 26, 1277-1281.
45. Startup, M. (1997). Awareness of own and other's schizophrenic illness. Schizophrenia Research 26, 203-211.
46. Takai, A., Uematsu, M., Ueki, H., Stone, K. & Kaiya, H. (1992). Insight and its related factors in chronic and schizophrenic patients: A preliminary study. European Journal of Psychiatry 6, 159-170.
47. Thompson, K., McGorry, P. & Harrigan, S. (2001). Reduced awareness of illness in first episode psychosis. Comprehensive Psychiatry 42, 498-503.
48. Verdoux, H., Lengronne, J., Liraud, F., Gonzalez, B., Assens, F., Abalan, F. & van Os, J. (2000). Medication adherence in psychosis: predictors and impact on outcome. A 2-year follow-up of first-admitted subjects. Acta Psychiatrica Scandinavica 102, 203-210.
49. White, R., Bebbington, P. E., Pearson, J., Johnson, S. & Ellis, D. (2000). The social context of insight in schizophrenia and other disorders. Social Psychiatry and Psychiatric Epidemiology 35, 500-507.
50. Young, D., Davila, R. & Scher, H. (1993). Unawareness of illness and neuropsychological performance in chronic schizophrenia. Schizophrenia Research 10, 117-124.
51. Young D., Zakzanis, K., Bailey, C., Davila, R., Griese, J. & Thom, A. (1998). Further parameters of insight and neuropsychological deficit in schizophrenia and other chronic mental disease. Journal of Nervous and Mental Disease 186, 44-50.