Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine

British Journal of Pharmacology

Volumn 149, Issue 2, 2006, Pages 163-169

  Kloda, A ^a   Adams, D J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Glutamate; NMDA receptors; Serotonin; Single point mutations; Voltage dependent block; Xenopus oocytes

Indexed keywords

ASPARAGINE; GLUTAMIC ACID; GLYCINE; MAGNESIUM ION; MUTANT PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; SEROTONIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; ELECTRIC FIELD; FEMALE; IC 50; NONHUMAN; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP; XENOPUS;

ANIMALS; FEMALE; MAGNESIUM; OOCYTES; POINT MUTATION; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SEROTONIN; XENOPUS LAEVIS;

EID: 33748498247     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706849     Document Type: Article

References (29)

1. 2A receptor. J Biol Chem 271: 14672-14675.
2. Bliss TV, Collingridge GL (1993). A synaptic model of memory: long term potentiation in the hippocampus. Nature 361: 31-39.
3. Boton R, Dascal N, Gillo B, Lass Y (1989). Two calcium-activated chloride conductances in Xenopus laevis oocytes permeabilized with the ionophore A23187. J Physiol 408: 511-534.
4. Burnashev N, Monyer H, Seeburg PH, Sakmann B (1992a). Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron 8: 189-198.
5. Burnashev N, Schoepfer R, Monyer H, Ruppersberg JP, Gunther W, Seeburg PH et al. (1992b). Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science 257: 1415-1419.
6. Castellano C, Cestari V, Ciamei A (2001). NMDA receptors in learning and memory processes. Curr Drug Targets 2: 273-283.
7. Cull-Candy S, Brickley S, Farrant M (2001). NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11: 327-335.
8. Dingledine R, Borges K, Bowie D, Traynelis SF (1999). The glutamate receptor ion channels. Pharmacol Rev 51: 7-61.
9. Hume RI, Dingledine R, Heinemann SF (1991). Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 253: 1028-1031.
10. Johnson MD (1994). Synaptic glutamate release by postnatal rat serotonergic neurons in microculture. Neuron 12: 433-442.
11. Kashiwagi K, Masuko T, Nguyen CD, Kuno T, Tanaka I, Igarashi K et al. (2002). Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore. Mol Pharmacol 61: 533-545.
12. Kloda A, Adams DJ (2005). Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine. Br J Pharmacol 144: 323-330.
13. Kuner T, Wollmuth LP, Karlin A, Seeburg PH, Sakmann B (1996). Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteine. Neuron 17: 343-352.
14. Kupper J, Ascher P, Neyton J (1996). Probing the pore region of recombinant N-methyl-D-aspartate channels using external and internal magnesium block. Proc Natl Acad Sci USA 93: 8648-8653.
15. 2+ block of recombinant NMDA channels mutated within the selectivity filter and expressed in Xenopus oocytes. J Physiol 507: 1-12.
16. Laube B, Kuhse J, Betz H (1998). Evidence for a tetrameric structure of recombinant NMDA receptors. J Neurosci 18: 2954-2961.
17. Leonard JP, Kelso SR (1990). Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current. Neuron 2: 53-60.
18. Masuko T, Suzuki I, Kizawa Y, Kusama-Eguchi K, Watanabe K, Kashiwagi K et al. (2004). Monoamines directly inhibit N-methyl-D-aspartate receptors expressed in Xenopus oocytes in a voltage-dependent manner. Neurosci Lett 371: 30-33.
19. 2+ of NMDA responses in spinal cord neurons. Nature 309: 261-263.
20. 2+ block site of the NMDA receptor channel. Nature 358: 673-675.
21. Nowak L, Bregestovsky P, Ascher P, Herbet A, Prochiantz A (1984). Magnesium gates glutamate-activated channels in mouse central neurons. Nature 307: 462-465.
22. Rosi S, Ramirez-Amaya V, Hauss-Wegrzyniak B, Wenk GL (2004). Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors. J Neuroinflammation 1: 12.
23. 2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor. J Biol Chem 268: 410-415.
24. Sharma G, Stevens CF (1996). Interactions between two divalent ion binding sites in N-methyl-D-aspartate receptor channels. Proc Natl Acad Sci USA 93: 14170-14175.
25. Verdoorn RA, Burnashev N, Monyer H, Seeburg PH, Sakmann B (1991). Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252: 1715-1718.
26. Waxman EA, Lynch DR (2005). N-methyl-D-aspartate receptor subtypes: multiple roles in excitoxicity and neurological disease. Neuroscientist 11: 37-49.
27. 2+. J Physiol 506: 13-32.
28. Wollmuth LP, Kuner T, Seeburg PH, Sakmann B (1996). Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels. J Physiol 491: 779-797.
29. Woodhull AM (1973). Ionic blockage of sodium channels in nerve. J Gen Physiol 61: 687-708.