A systematic review of multivitamin and multimineral supplementation for infection

Journal of Human Nutrition and Dietetics

Volumn 19, Issue 3, 2006, Pages 179-190

  Stephen, Audrey I ^a,b   Avenell, A ^b  

^a ROBERT GORDON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Adults; Infection; Meta analysis; Minerals; Randomized controlled trials; Systematic review; Vitamins

Indexed keywords

ALPHA TOCOPHEROL; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ASCORBIC ACID; COPPER; MINERAL; MULTIVITAMIN; PLACEBO; RETINOL; SELENIUM; TRACE ELEMENT; ZINC;

BACTERIAL INFECTION; CLINICAL TRIAL; COCHRANE LIBRARY; CONFIDENCE INTERVAL; EMBASE; HEALTH ECONOMICS; HUMAN; LENGTH OF STAY; MALNUTRITION; MEDLINE; META ANALYSIS; MORBIDITY; MORTALITY; NUTRITIONAL STATUS; REVIEW; SYSTEMATIC REVIEW; UNSPECIFIED SIDE EFFECT; VACCINATION; VITAMIN SUPPLEMENTATION;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CONFIDENCE INTERVALS; DIETARY SUPPLEMENTS; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; INFECTION; INFECTION CONTROL; MALE; MALNUTRITION; MIDDLE AGED; MINERALS; NUTRITIONAL STATUS; RANDOMIZED CONTROLLED TRIALS; RISK; TREATMENT OUTCOME; VITAMINS;

EID: 33748454066     PISSN: 09523871     EISSN: 1365277X     Source Type: Journal    
DOI: 10.1111/j.1365-277X.2006.00694.x     Document Type: Review

References (40)

1. Alderson, P., Green, S. & Higgins, J.P.T. (2003) Cochrane Reviewer's Handbook 4.2.2. Available at: http://www.cochrane.dk/cochrane/handbook/ hbook.htm. Accessed: 3/5/03.
2. Allsup, S.J., Shenkin, A., Gosney, M.A., Taylor, S., Taylor, W., Hammond, M. & Zambon, M.C. (2004) Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial. J. Am. Geriatr. Soc. 52, 20-24.
3. Avenell, A., Handoll, H.H. & Grant, A.M. (2001) Lessons for search strategies from a systematic review, in The Cochrane Library, of nutritional supplementation trials in patients after hip fracture. Am. J. Clin. Nutr. 73, 505-510.
4. Barringer, T.A., Kirk, J.K., Santaniello, A.C., Foley, K.L. & Michielutte, R. (2003) Effect of a multivitamin and mineral supplement on infection and quality of life. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 138, 365-371.
5. Berger, M.M., Spertini, F., Shenkin, A., Wardle, C., Wiesner, L., Schindler, C. & Chiolero, R.L. (1998) Trace element supplementation modulates pulmonary infection rates after major burns: A double-blind, placebo-controlled trial. Am. J. Clin. Nutr. 68, 365-371.
6. Berger, M.M., Baines, M., Wardle, C.A., Cayeux, C., Chiolero, R. & Shenkin, A. (2002) Trace element supplements modulate tissue levels, antioxidant status and clinical course after major burns: Preliminary results. Clin. Nutr. 21 (Suppl. 1), 66.
7. CBC News (2006) The secret life of Dr Chandra. Available at: http://www.cbc.ca/national/news/chandra/. Accessed: 9/3/06.
8. Chandra, R.K. (1992) Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 340, 1124-1127.
9. Chandra, R.K. (2002) Influence of multinutrient supplement on immune responses and infection related illness in 50-65 year old individuals. Nutr. Res. 22, 5-11.
10. Chavance, M., Herbeth, B., Lemoine, A. & Zhu, B.P. (1993) Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial. Int. J. Vitam. Nutr. Res. 63, 11-16.
11. Chuang, C.H., Sheu, B.S., Huang, A.H., Yang, H.B. & Wu, J.J. (2002) Vitamin C and E supplements to lansoprazole-amoxicillin-metronidazole triple therapy may reduce the eradication rate of metronidazole-susceptible Helicobacter pylori infection. Helicobacter 7, 310-316.
12. Cochrane Infectious Diseases Group (2002) Resources for Reviewers. Available at: http://www.liv.ac.uk/lstm/ehcap/CIDG/ welcome.htm#reviewerresources. Accessed: 10/10/02.
13. Cochrane Musculoskeletal Injuries Group (CMSIG) (2003) Quality assessment tool. Available at: http://www.mrw.interscience.wiley.com/ cochrane/clabout/articles/MUSKINJ/frame.html. Accessed 5/6/2003.
14. Cunningham-Rundles, B.M. (2002) Evaluation of the effects of nutrients on immune function. In Nutrition and Immune Function. eds P.C. Calder, C.J. Field & H.S. Gill, pp. 21-39. Wallingford: CABI Publishing.
15. Department of Health (1991) Dietary Reference Values for Food, Energy and Nutrients for the United Kingdom. p. 49. London: HMSO.
16. Euroqol (2005) Available at: http://www.euroqol.org/web/. Accessed: 12/9/ 2005.
17. Finch, S., Doyle, W., Lowe, C., Bates, C.J., Prentice, A., Smithers, G. & Clarke, P.C. (1998) National Diet and Nutrition Survey: People aged 65 years and over. London: The Stationery Office.
18. Girodon, F., Lombard, M., Galan, P., Brunet-Lecomte, P., Monget, A.L., Arnaud, J., Preziosi, P. & Hercberg, S. (1997) Effect of a two-year supplementation with low doses of antioxidant vitamins and/or minerals in elderly subjects on levels of nutrients and antioxidant defense parameters. J. Am. Coll. Nutr. 16, 357-365.
19. Girodon, F., Galan, P., Monget, A.L., Boutron-Ruault, M.C., Brunet-Lecomte, P., Preziosi, P., Arnaud, J., Manuguerra, J.C. & Hercberg, S. and the MIN. VIT. AOX. geriatric network. (1999) Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: A randomized controlled trial. Arch. Intern. Med. 159, 748-754.
20. Graat, J.M., Schouten, E.G. & Kok, F.J. (2002) Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: A randomized controlled trial. JAMA 288, 715-721.
21. Hemila, H., Kaprio, J., Albanes, D., Heinonen, O.P. & Virtamo, J. (2002) Vitamin C, vitamin E, and beta-carotene in relation to common cold incidence in male smokers. Epidemiology 13, 32-37.
22. Higgins, J.P.T., Thompson, S.G., Deeks, J.J. & Altman, D.G. (2003) Measuring inconsistency in meta-analyses. BMJ 327, 557-560.
23. Jain, A.L. (2002) Influence of vitamins and trace elements on the incidence of respiratory infection in the elderly. Nutr. Res. 22, 85-87.
24. Karyadi, E., West, C.E., Schultink, W., Nelwan, R.H., Gross, R., Amin, Z., Dolmans, W.M., Schlebusch, H. & Van.der. Meer, J.W. (2002) A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: Effects on clinical response and nutritional status. Am. J. Clin. Nutr. 75, 720-727.
25. Lesourd, B. (1999) Immune response during disease and recovery in the elderly. Proc. Nutr. Soc. 58, 85-98.
26. Lesourd, B., Raynaud-Symon, A. & Mazari, L. (2002) Nutrition and ageing of the immune system. In Nutrition and Immune Function. eds P.C. Calder, C.J. Field & H.S. Gill, pp. 357-374. Wallingford: CABI Publishing.
27. Lui, B.A., McGreer, A., Simor, A., McArthur, M., Aghdassi, E. & Allard, J. (2001) Effect of multivitamin and mineral supplementation on infection rates in elderly long term care residents. Abstr. Intersci. Conf. Antimicrob. Agents Chemother. 41, 413.
28. Moher, D., Schulz, K.F. & Altman, D.G. (2001) The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 357, 1191-1194.
29. Nathens, A.B., Neff, M.J., Jurkovich, G.J., Klotz, P., Farver, K., Ruzinski, J.T., Radella, F., Garcia, I. & Maier, R.V. (2002) Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann. Surg. 236, 814-822.
30. Pokorny, D., Puxkandl, H., Benedik, H., Hampl, G. & Sollner, J. (1971) Therapeutic effect of a vitamin-mineral combination on welfare patients. Wien. Z. Inn. Med. 52, 446-457.
31. Quality Metric Incorporated (2003) SF 36.org: A community for measuring health outcomes using SF tools. Available at: http://www.sf-36.org. Accessed: 4/10/03.
32. Ruston, D., Hoare, J., Henderson, L., Gregory, J., Bates, C.J., Prentice, A., Birch, M., Swan, G. & Farron, M. (2004) National Diet and Nutrition Survey: Adults ageH 19-64 years. Available at: http://www.food.gov.uk/science/101717/ndnsdocuments/ndns4. Accessed: 31/1/04.
33. Smith, R. (2005) Investigating the previous studies of a fraudulent author. BMJ 331, 288-291.
34. The Musella Foundation (2004) Clinical trials and noteworthy treatments for brain tumours: KarnofHky score. Available at: http://virtualtrials.com/karnofsky.cfm. Accessed: 4/10/04.
35. The Writing Group of the MAVIS Trial Group (2005) Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): Pragmatic, randomised, double blind, placebo controlled trial. BMJ 331, 324-329.
36. Vlaming, S., Biehler, A., Hennessey, E.M., Jamieson, C.P., Chattophadhyay, S., Obeid, O.A., Archer, C., Farrell, A., Durman, K., Warrington, S. & Powell-Tuck, J. (2001) Should the food intake of patients admitted to acute hospital services be routinely supplemented? A randomized placebo controlled trial. Clin. Nutr. 20, 517-526.
37. Watters, J.M., Vallerand, A., Kirkpatrick, S.M., Abbott, H.E., Norris, S., Wells, G. & Barber, G.G. (2002) Limited effects of micronutrient supplementation on strength and physical function after abdominal aortic aneurysmectomy. Clin. Nutr. 21, 321-327.
38. White, C. (2004) Three journals raise doubts on validity of Canadian studies. BMJ 328, 67.
39. World Health Organisation (2002) The European Health Report, no. 97. Denmark: WHO Europe.
40. World Health Organisation (2005) World health report 2004 statistical annex. Available at: http://www.who.int/whr/2004/annex/en/. Accessed 18/ 3/05.