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Volumn 22, Issue 3, 2006, Pages 461-468

Toxicological investigations on the methanol sub-fraction of the seeds of Carica papaya as a male contraceptive in albino rats

Author keywords

Acute and sub chronic toxicity; Albino rats; Carica papaya seeds; Male contraception; Methanol sub fraction

Indexed keywords

CARICA PAPAYA EXTRACT; MALE CONTRACEPTIVE AGENT; METHANOL;

EID: 33748432404     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2006.01.002     Document Type: Article
Times cited : (24)

References (24)
  • 1
    • 0026498261 scopus 로고
    • Antifertility investigations on the crude chloroform extract of Carica papaya Linn. seeds in male albino rats
    • Lohiya N.K., and Goyal R.B. Antifertility investigations on the crude chloroform extract of Carica papaya Linn. seeds in male albino rats. Indian J Exp Biol 30 (1992) 1051-1055
    • (1992) Indian J Exp Biol , vol.30 , pp. 1051-1055
    • Lohiya, N.K.1    Goyal, R.B.2
  • 2
    • 0032992709 scopus 로고    scopus 로고
    • Reversible contraception with chloroform extract of Carica papaya Linn. seeds in male rabbits
    • Lohiya N.K., Pathak N., Mishra P.K., and Manivannan B. Reversible contraception with chloroform extract of Carica papaya Linn. seeds in male rabbits. Reprod Toxicol 13 (1999) 59-66
    • (1999) Reprod Toxicol , vol.13 , pp. 59-66
    • Lohiya, N.K.1    Pathak, N.2    Mishra, P.K.3    Manivannan, B.4
  • 3
    • 2042532312 scopus 로고    scopus 로고
    • Prospects of developing a plant based male contraceptive pill
    • Chowdhary S.R., Gupta C.M., and Kamboj V.P. (Eds), Central Drug Research Institute, Lucknow
    • Lohiya N.K., Manivannan B., Mishra P.K., and Pathak N. Prospects of developing a plant based male contraceptive pill. In: Chowdhary S.R., Gupta C.M., and Kamboj V.P. (Eds). Current status in fertility regulation: indigenous and modern approaches (2001), Central Drug Research Institute, Lucknow 99-119
    • (2001) Current status in fertility regulation: indigenous and modern approaches , pp. 99-119
    • Lohiya, N.K.1    Manivannan, B.2    Mishra, P.K.3    Pathak, N.4
  • 4
    • 0033853709 scopus 로고    scopus 로고
    • Sterility due to inhibition of sperm motility by oral administration of benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats
    • Pathak N., Mishra P.K., Manivannan B., and Lohiya N.K. Sterility due to inhibition of sperm motility by oral administration of benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats. Phytomedicine 7 (2000) 325-333
    • (2000) Phytomedicine , vol.7 , pp. 325-333
    • Pathak, N.1    Mishra, P.K.2    Manivannan, B.3    Lohiya, N.K.4
  • 5
    • 0036211840 scopus 로고    scopus 로고
    • The chloroform extract of the seeds of Carica papaya by oral administration induces long-term reversible azoospermia in langur monkey Presbytis entellus entellus
    • Lohiya N.K., Manivannan B., Mishra P.K., Pathak N., Sriram S., Bhande S.S., et al. The chloroform extract of the seeds of Carica papaya by oral administration induces long-term reversible azoospermia in langur monkey Presbytis entellus entellus. Asian J Androl 4 (2002) 17-26
    • (2002) Asian J Androl , vol.4 , pp. 17-26
    • Lohiya, N.K.1    Manivannan, B.2    Mishra, P.K.3    Pathak, N.4    Sriram, S.5    Bhande, S.S.6
  • 6
    • 0032608960 scopus 로고    scopus 로고
    • Long and medium term carcinogenicity studies in animals and short term genotoxicity tests
    • Feron V.J., Schwarz M., Hemniki K., and Krewski D. Long and medium term carcinogenicity studies in animals and short term genotoxicity tests. IARC Science Publication 131 (1999) 103-129
    • (1999) IARC Science Publication , vol.131 , pp. 103-129
    • Feron, V.J.1    Schwarz, M.2    Hemniki, K.3    Krewski, D.4
  • 7
    • 2542510245 scopus 로고    scopus 로고
    • ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact
    • Muller L., Kikuchi Y., Probst G., Schechtman L., Shimada H., Sofuni T., et al. ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact. Mut Res 436 (1999) 195-225
    • (1999) Mut Res , vol.436 , pp. 195-225
    • Muller, L.1    Kikuchi, Y.2    Probst, G.3    Schechtman, L.4    Shimada, H.5    Sofuni, T.6
  • 8
    • 0342316476 scopus 로고    scopus 로고
    • Human biological relevance and the use of threshold arguments in regulatory genotoxicity assessment: experience with pharmaceuticals
    • Muller L., and Kasper P. Human biological relevance and the use of threshold arguments in regulatory genotoxicity assessment: experience with pharmaceuticals. Mut Res 464 (2000) 19-34
    • (2000) Mut Res , vol.464 , pp. 19-34
    • Muller, L.1    Kasper, P.2
  • 9
    • 0035978873 scopus 로고    scopus 로고
    • Mutagens that are not carcinogens: faulty theory or faulty test
    • Zeigler E. Mutagens that are not carcinogens: faulty theory or faulty test. Mut Res 492 (2001) 29-38
    • (2001) Mut Res , vol.492 , pp. 29-38
    • Zeigler, E.1
  • 10
    • 33748412912 scopus 로고    scopus 로고
    • Guidelines for care and use of animals for scientific research. New Delhi: Indian National Science Academy; 2000.
  • 11
    • 33748426668 scopus 로고    scopus 로고
    • OPPTS harmonised test guidelines series 870. Health effects test guidelines. Washington: United States Environmental Protection Agency; 1996.
  • 12
    • 77049180105 scopus 로고
    • Standardizing a method for clinical haemoglobinometry
    • Crosby W.H., Munn J.I., and Furth F.W. Standardizing a method for clinical haemoglobinometry. US Armed Forces Med J 5 (1954) 693-703
    • (1954) US Armed Forces Med J , vol.5 , pp. 693-703
    • Crosby, W.H.1    Munn, J.I.2    Furth, F.W.3
  • 13
    • 33444477870 scopus 로고
    • Routine use of ultramicro methods in the clinical laboratory
    • Natelson S. Routine use of ultramicro methods in the clinical laboratory. Am J Clin Pathol 21 (1951) 1153-1172
    • (1951) Am J Clin Pathol , vol.21 , pp. 1153-1172
    • Natelson, S.1
  • 15
    • 33748418046 scopus 로고    scopus 로고
    • WHO. Laboratory manual for examination of human semen and sperm-cervical mucus interaction. New York: Cambridge University Press; 1999.
  • 17
    • 4544225471 scopus 로고
    • Determination of glycogen
    • Montgomery R. Determination of glycogen. Arch Biochem Biophys 67 (1957) 378-386
    • (1957) Arch Biochem Biophys , vol.67 , pp. 378-386
    • Montgomery, R.1
  • 19
    • 0008696809 scopus 로고
    • Isolation and determination of neuraminic (sialic) acid by resorcinol reaction
    • Glick D. (Ed), Interscience, New Delhi
    • Svennerholm L. Isolation and determination of neuraminic (sialic) acid by resorcinol reaction. In: Glick D. (Ed). Methods of biochemical analysis (1960), Interscience, New Delhi
    • (1960) Methods of biochemical analysis
    • Svennerholm, L.1
  • 21
    • 33748429604 scopus 로고    scopus 로고
    • WHO. Laboratory manual for examination of human semen and sperm-cervical mucus interaction. New York: Cambridge University Press; 1992.
  • 22
    • 21244440195 scopus 로고    scopus 로고
    • A subchronic toxicity study in rats and genotoxicity tests with an aqueous ethyl cellulose dispersion
    • Demerlis C.C., Schoneker D.R., and Borzelleca J.F. A subchronic toxicity study in rats and genotoxicity tests with an aqueous ethyl cellulose dispersion. Food Chem Toxicol (2005)
    • (2005) Food Chem Toxicol
    • Demerlis, C.C.1    Schoneker, D.R.2    Borzelleca, J.F.3
  • 23
    • 0013568334 scopus 로고
    • Measurement of chronic toxicity
    • Paget G.E. (Ed), Blackwell, Oxford
    • Benitz K.F. Measurement of chronic toxicity. In: Paget G.E. (Ed). Methods of toxicology (1970), Blackwell, Oxford 82-131
    • (1970) Methods of toxicology , pp. 82-131
    • Benitz, K.F.1
  • 24
    • 33748427653 scopus 로고
    • Drug safety evaluation-pre-clinical considerations
    • Fielding S., and Lal H. (Eds), Futura, Mt. Kisco, NY
    • D' Aguanno W. Drug safety evaluation-pre-clinical considerations. In: Fielding S., and Lal H. (Eds). Industrial pharmacology: neuroleptic I (1974), Futura, Mt. Kisco, NY 317-332
    • (1974) Industrial pharmacology: neuroleptic , vol.I , pp. 317-332
    • D' Aguanno, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.