Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy

Experimental Neurology

Volumn 201, Issue 2, 2006, Pages 519-524

  Biagini, Giuseppe ^a   Baldelli, Enrica ^a   Longo, Daniela ^a   Pradelli, Luca ^a   Zini, Isabella ^a   Rogawski, Michael A ^b   Avoli, Massimo ^c,d  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Epileptogenesis; Glia; Hippocampus; Neurosteroid; Pilocarpine; Status epilepticus

Indexed keywords

ANTICONVULSIVE AGENT; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); FINASTERIDE; NEUROSTEROID; PILOCARPINE; STEROID; STEROID 5ALPHA REDUCTASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; EPILEPTIC STATE; EPILEPTOGENESIS; GLIA CELL; HIPPOCAMPUS; LATENT PERIOD; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SEIZURE SUSCEPTIBILITY; TEMPORAL LOBE EPILEPSY;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 5-ALPHA REDUCTASE INHIBITORS; ANIMALS; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; ENZYME INHIBITORS; EPILEPSY, TEMPORAL LOBE; FINASTERIDE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; NEUROGLIA; NEURONS; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; STATUS EPILEPTICUS; STEROIDS; TESTOSTERONE 5-ALPHA-REDUCTASE; TIME FACTORS;

EID: 33748417555     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.04.029     Document Type: Article

References (25)

1. Belluardo N., Mudo G., Jiang X.H., and Condorelli D.F. Induction of astroglial gene expression by experimental seizures in the rat: spatio-temporal patterns of the early stages. Glia 16 (1996) 174-186
2. Biagini G., Pich E.M., Carani C., Marrana P., Gustafsson J.A., Fuxe K., and Agnati L.F. Indole-pyruvic acid, a tryptophan ketoanalogue, antagonizes the endocrine but not the behavioral effects of repeated stress in a model of depression. Biol. Psychiatry 33 (1993) 712-719
3. Biagini G., Sala D., and Zini I. Diethyldithiocarbamate, a superoxide dismutase inhibitor, counteracts the maturation of ischemic-like lesions caused by endothelin-1 intranstriatal injection. Neurosci. Lett. 190 (1995) 212-216
4. Biagini G., Avoli M., Marcinkiewicz J., and Marcinkievicz M. Brain-derived neurotrophic factor superinduction parallels antiepileptic-neuroprotective treatment in the pilocarpine epilepsy model. J. Neurochem. 76 (2001) 1814-1822
5. Biagini G., D'Arcangelo G., Baldelli E., D'Antuono M., Tancredi V., and Avoli M. Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus. Neuromol. Med. 7 (2005) 325-342
6. Borges K., Gearing M., McDermott D.L., Smith A.B., Almonte A.G., Wainer B.H., and Dingledine R. Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Exp. Neurol. 182 (2003) 21-34
7. Burnham W.M. The GABA hypothesis of kindling: recent assay studies. Neurosci. Biobehav. Rev. 13 (1989) 281-288
8. Clifford D.B., Olney J.W., Maniotis A., Collins R.C., and Zorumski C.F. The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. Neuroscience 23 (1987) 953-968
9. Herzog A.G., and Frye C.A. Seizure exacerbation associated with inhibition of progesterone metabolism. Ann. Neurol. 53 (2003) 390-391
10. King S.R., Manna P.R., Ishii T., Syapin P.J., Ginsberg S.D., Wilson K., Walsh L.P., Parker K.L., Stocco D.M., Smith R.G., and Lamb D.J. An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J. Neurosci. 22 (2002) 10613-10620
11. Kokate T.G., Svensson B.E., and Rogawski M.A. Anticonvulsant activity of neurosteroids: correlation with γ-aminobutyric acid-evoked chloride current potentiation. J. Pharmacol. Exp. Ther. 270 (1994) 1223-1229
12. Kokate T.G., Banks M.K., Magee T., Yamaguchi S., and Rogawski M.A. Finasteride, a 5α-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. J. Pharmacol. Exp. Ther. 288 (1999) 679-684
13. Lambert J.J., Belelli D., Peden D.R., Vardy A.W., and Peters J.A. Neurosteroid modulation of GABAA receptors. Prog. Neurobiol. 71 (2003) 67-80
14. Leite J.P., Bortolotto Z.A., and Cavalheiro E.A. Spontaneous recurrent seizures in rats: an experimental model of partial epilepsy. Neurosci. Biobehav. Rev. 14 (1990) 511-517
15. Liu Z., Nagao T., Desjardins G.C., Gloor P., and Avoli M. Quantitative evaluation of neuronal loss in the dorsal hippocampus in rats with long-term pilocarpine seizures. Epilepsy Res. 17 (1994) 237-247
16. Mellon S.H., and Griffin L.D. Neurosteroids: biochemistry and clinical significance. Trends Endocrinol. Metab. 13 (2002) 35-43
17. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 4th ed (1998), Academic Press, San Diego
18. Poirier J.L., Čapek R., and De Koninck Y. Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus. Neuroscience 97 (2000) 59-68
19. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32 (1972) 281-294
20. Reddy D.S., Castaneda D.C., O'Malley B.W., and Rogawski M.A. Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J. Pharmacol. Exp. Ther. 310 (2004) 230-239
21. Represa A., Niquet J., Pollard H., and Ben-Ari Y. Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats. J. Neurobiol. 26 (1995) 413-425
22. Roby K.F., Larsen D., Deb S., and Soares M.J. Generation and characterization of antipeptide antibodies to rat cytochrome P-450 side-chain cleavage enzyme. Mol. Cell. Endocrinol. 79 (1991) 13-20
23. Rogawski M.A., and Reddy D.S. Neurosteroids: endogenous modulators of seizure susceptibility. In: Rho J.M., Sankar R., and Cavazos J. (Eds). Epilepsy: Scientific Foundations of Clinical Treatment (2004), Marcel Dekker, New York 319-355
24. Shibuya K., Takata N., Hojo Y., Furukawa A., Yasumatsu N., Kimoto T., Enami T., Suzuki K., Tanabe N., Ishii H., Mukai H., Takahashi T., Hattori T.A., and Kawato S. Hippocampal cytochrome P450s synthesize brain neurosteroids which are paracrine neuromodulators of synaptic signal transduction. Biochim. Biophys. Acta 1619 (2003) 301-316
25. Zwain I.H., and Yen S.S. Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology 140 (1999) 3843-3852