Helicobacter pylori genotypes in children from a population at high gastric cancer risk: No association with gastroduodenal histopathology

American Journal of Gastroenterology

Volumn 101, Issue 9, 2006, Pages 2113-2122

  Costa Lopes, Ana Isabel ^a   Palha, Ana ^a   Monteiro, Lurdes ^b   Olcastro, Mónica ^b   Pelerito, Ana ^b   Fernandes, Afonso ^a   Da Fonseca Lopes, Ana Isabel Gouveia ^a  

^a HOSPITAL DE SANTA MARIA   (Portugal)

^b NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CAGA PROTEIN; PROTEIN ICEA; UNCLASSIFIED DRUG; VACUOLATING TOXIN;

ADOLESCENT; ADULT; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CANCER RISK; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE SEVERITY; DUODENUM BIOPSY; FEMALE; GASTROINTESTINAL ENDOSCOPY; GENE FREQUENCY; GENETIC MARKER; GENOTYPE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFANT; INFLAMMATION; ISOLATION PROCEDURE; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; SCORING SYSTEM; STOMACH CANCER;

ADOLESCENT; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BIOPSY; CHILD; CHILD, PRESCHOOL; DNA, BACTERIAL; DUODENUM; ENDOSCOPY, GASTROINTESTINAL; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INFANT; MALE; POLYMERASE CHAIN REACTION; PREVALENCE; PROSPECTIVE STUDIES; PYLORIC ANTRUM; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STOMACH NEOPLASMS;

EID: 33748343176     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2006.00732.x     Document Type: Article

References (49)

1. Blaser MJ. Hypothesis: The changing relationships of Helicobacter pylori and humans: Implications for health and disease. J Infect Dis 1999;179:1523-30.
2. Go MF. Review article: Natural history and epidemiology of Helicobacter pylori infection. Aliment Pharmacol Ther 2002;16(suppl 1):3-15.
3. Correa P. Human gastric carcinogenesis: A multistep and multifactorial process. First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992;52:6735-40.
4. Graham DY. Helicobacter pylori infection is the primary cause of gastric cancer. J Gastroenterol 2000;35:90-7.
5. Azuma T, Ito S, Sato F, et al. The role of the HLA-DQA 1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection. Cancer 1998;82:1013-8.
6. El Omar EM, Carrington M, Chow W, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000;404:398-402.
7. Rad R, Prinz C, Neu B, et al. Synergistic effect of Helicobacter pylori virulence factors and interleukin-1polymorphisms for the development of severe histological changes in the gastric mucosa. J Infect Dis 2003;188:272-81.
8. Correa P. New strategies for the prevention of gastric cancer: Helicobacter pylori and genetic susceptibility. J Surg Oncol 2005;90:134-8.
9. Atherton JC. The clinical relevance of strain types of Helicobacter pylori. Gut 1997;40:701-3.
10. van Doorn LJ, Figueiredo C, Sanna R, et al. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology 1998;115:58-66.
11. Blaser MJ, Perez-Perez GI, Kleanthous H, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55:2111-5.
12. Kuipers EJ, Perez-Perez GI, Meuwissen SG, et al. Helicobacter pylori and atrophic gastritis: Importance of the cagA status. J Natl Cancer Inst 1995;87:1777-80.
13. Atherton JC, Peek RMJ, Tham KT, et al. Clinical and pathological importance of heterogeneity in vac A, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997;112:92-9.
14. Peek RM, Thompson SA, Donahue JP, et al. Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA that is associated with clinical outcome. Proc Assoc Am Physicians 1998;110:531-44.
15. Warburton VJ, Everett S, Mapstone NP, et al. Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori gastritis. J Clin Pathol 1998;51:55-61.
16. van der Ende A, Pan ZJ, Bart A, et al. cagA-positive Helicobacter pylori populations in China and The Netherlands are distinct. Infect Immun 1998;66:1822-6.
17. van Doorn LJ, Figueiredo C, Megraud F, et al. Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology 1999;116:823-30.
18. Yamaoka Y, Kodama T, Gutierrez O, et al. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: Studies in four different countries. J Clin Microbiol 1999;37:2274-9.
19. Figueiredo C, van Doorn LJ, Nogueira C, et al. Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and reveal a high prevalence of infections with multiple strains. Scand J Gastroenterol 2001;36:128-35.
20. Gold B, van Doorn LJ, Guarner J, et al. Genotypic, clinical, and demographic characteristics of children infected with Helicobacter pylori. J Clin Microbiol 2001;39:1348-52.
21. Dzierzanowska-Fangrat K, Crabtree JE, Rozynek E, et al. Helicobacter pylori cagA genotype and density of colonization in relation to gastric inflammation in children. Eur J Gastroenterol Hepatol 2002;14:1303-7.
22. Gallo N, Zambon CF, Navaglia F, et al. Helicobacter pylori infection in children and adults: A single pathogen but a different pathology. Helicobacter 2003;8:21-8.
23. Black RJ, Bray F, Ferlay J, et al. Cancer incidence and mortality in the European Union: Cancer registry data and estimates of national incidence for 1990. Eur J Cancer 1997;33:1075-7.
24. Lunet N, Pina F, Barros H. Regional trends in Portuguese gastric cancer mortality (1984-1999). Eur J Cancer Prev 2004;13:271-5.
25. Dixon MF, Genta RM, Yardley JH, et al. Classification and grading of gastritis. The updated Sydney system. Am J Surg Pathol 1996;20:1161-81.
26. Whitehead R. Morphological aspects of duodenitis. Scand J Gastroenterol 1982;79(suppl):80-3.
27. Mégraud F, Lehn N, Lind T, et al. Antimicrobial susceptibility testing of H. pylori in large multicenter trial: The MACH 2 study. Antimicrob Agents Chemother 1999;43:2747-52.
28. NCCLS M100 - S12. Performance standards for antimicrobial susceptibility testing. Twelfth International supplement 2002;22:(1).
29. Pitcher DG, Saunders NA, Owen RJ. Rapide extraction of bacterial genomic DNA with guanidinium thiocyanate. Lett Appl Microbiol 1989;8:151-6.
30. Atherton JC, Cao P, Peek RM, et al. Mosaicism in the vacuolating cytotoxin alleles of Helicobacter pylori. J Biol Chem 1995;270:17771-7.
31. Atherton JC, Cover TL, Twells RJ, et al. Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori. J Clin Microbiol 1999;37:2979-82.
32. Ernst PB, Gold BD. Helicobacter pylori in childhood: New insights into the immunopathogenesis of gastric disease and implications for managing infection in children. J Pediatr Gastrenterol Nutr 1999;28:462-73.
33. Drumm B, Day AS, Gold B, et al. Helicobacter pylori and peptic ulcer: Working Group Report of the Second World Congress of Pediatric Gastrenterology, Hepatology and Nutrition. J Pediatr Gastrenterol Nutr 2004;39:S626-31.
34. Uhlig HH, Tannapfel A, Mossner J, et al. Histopathological parameters of Helicobacter pylori-associated gastritis in children and adolescents: Comparison with findings in adults. Scand J Gastrenterol 2003;38:701-6.
35. Alarcon T, Domingo D, Martinez MJ, et al. cagA gene and vacA alleles in Spanish Helicobacter pylory clinical isolates from patients at different ages. FEMS Immunol Med Microbiol 1999;24:215-9.
36. Queiroz DMM, Mendes EN, Carvalho AST, et al. Factors associated with H. pylori infection by a cagA positive strain in children. J Infect Dis 2000;181:626-30.
37. Karhukorpi J, Yan Y, Kolho KL, et al. cagA, vacA and iceA virulence genes of Helicobacter pylori isolates of children in Finland. Eur J Clin Microbiol Infect Dis 2000;19:790-3.
38. Gusmão VR, Mendes EN, Queiroz DMM, et al. VacA genotypes in Helicobacter pylori strins isolated from children with and without duodenal ulcer in Brasil. J Clin Microbiol 2000;38:2853-7.
39. Oleastro M, Gerhard M, Lopes AI, et al. Helicobacter pylori virulence genotypes in Portuguese children and adults with gastroduodenal pathology. Eur J Clin Microbiol Infect Dis 2003;22:85-91.
40. Podzorski RP, Podzorski DS,Wuerth A, et al. Analysis of the vacA, cagA, cagE, iceA, and babA 2 genes in Helicobacter pylori from sixty-one pediatric patients from the Midwestern United States. Diagn Microbiol Infect Dis 2003;46:83-8.
41. Azuma T, Kato S, Zhou W, et al. Diversity of vacA and cagA genes of Helicobacter pylori in Japanese children. Aliment Pharmacol Ther 2004;20(suppl 1):7-12.
42. Gonzalez-Valencia G, Atherton JC, Munoz O, et al. Helicobacter pylori vacA and cagA genotypes in Mexican adults and children. J Infect Dis 2000;182:1450-4.
43. Kuipers EJ, Israel DA, Kusters JG, et al. Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart from the same host. J Infect Dis 2000;181:273-82.
44. Luzza F, Pensabene L, Imeneo M, et al. Antral nodularity and positive cagA serology are distinct and relevant markers of severe gastric inflammation in children with H. pylori infection. Helicobacter 2002;7:46-52.
45. Bahú MG, Reverbel da Silveira T, Maguilnick I, et al. Endoscopic nodular gastritis: an endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori. J Pediatr Gastrenterol Nutr 2003;36:217-22.
46. Bedoya A, Garay J, Sanzon F, et al. Histopathology of gastritis in Helicobacter pylori-infected children from populations at high and low gastric cancer risk. Hum Pathol 2003;34:206-13.
47. Guarner J, Bartlett J, Whistler T, et al. Can pre-neoplastic lesions be detected in gastric biopsies of children with H. pylori infection? J Pediatr Gastrenterol Nutr 2003;37:309-14.
48. Quina MG, (on behalf of the Grupo de Estudo Portugûes do Helicobacter pylori). Helicobacter pylori: the Portuguese scene. Eur J Cancer Prev 1994;3(suppl 2):65-7.
49. Ferlay J, Bray F, Pisani P, et al. Globocan 2000: Cancer incidence, mortality and prevalence worldwide, version 1.0. Lyon: IARC Cancer Base 2001, IARC Press; no. 5.