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For the preparation of 1, see: R. G. Janssen, W. Verboom, D. N. Reinhoudt, A. Casnati, M. Freriks, A. Pochini, F. Uggozoli, R. Ungaro, P. M. Nieto, M. Carramolino, F. Cuevas, P. Prados, J. de Mendoza, Synthesis 1993, 380-385.
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25
-
-
85083147001
-
-
note
-
We first prepared 6 according to this previously reported synthesis. However, the obtained low overall yield (< 20%, 22% in the literature) as well as long time and hazardous procedures led us to develop a new synthetic strategy.
-
-
-
-
26
-
-
0037293002
-
-
S.-S. Jew, B.-S. Park, D.-Y. Lim, M. G. Kim, I. K. Chung, J. H. Kim, C. I. Hong, J.-K. Kim, H.-J. Park, J.-H. Lee, H.-G. Park, Bioorg. Med. Chem. Lett. 2003, 13, 609-612.
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-
27
-
-
85083152447
-
-
note
-
It is noteworthy that 7 decomposed within a few days at room temperature and thus should be kept at low temperature.
-
-
-
-
28
-
-
13844317010
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3/calix ratio: S. Le Gac, X. Zeng, O. Reinaud, I. Jabin, J. Org. Chem. 2005, 70, 1204-1210.
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Le Gac, S.1
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29
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0000435228
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-
30
-
-
85083146092
-
-
note
-
The carbon resonances of the included EtOH molecule were also determined and attributed thanks to an HMBC spectrum (see the Experimental Section and the Supporting Information: Figure S26).
-
-
-
-
31
-
-
85083140734
-
-
note
-
+.
-
-
-
-
32
-
-
85083147857
-
-
note
-
The relative proportion of this minor dissymmetrical species did not change upon the addition of a large excess of EtOH.
-
-
-
-
33
-
-
0038633748
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O. Sénèque, M.-N. Rager, M. Giorgi, O. Reinaud, J. Am. Chem. Soc. 2000, 122, 6183-6189.
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Sénèque, O.1
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-
34
-
-
85083142997
-
-
note
-
+) being observed.
-
-
-
-
35
-
-
85083120734
-
-
note
-
-: Figure S22).
-
-
-
-
36
-
-
1642458294
-
-
For a simple tmpa ligand, three successive protonation constants have been reported: K = 2.7, 4.5 and 6.3. Hence, if the calix-tmpa ligand were to present the same basic properties, it should easily undergo polyprotonation in a strong acidic medium. See: J. C. Mareque-Rivas, R. Prabaharan, R. Torres Martin de Rosales, Chem. Commun. 2004, 76-77.
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Mareque-Rivas, J.C.1
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37
-
-
85083142175
-
-
note
-
The proportion of this minor dissymmetrical species did not increase upon the addition of a large excess of PicH.
-
-
-
-
38
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17144378984
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