Potent inhibition of HIV-1 gene expression and TAT-mediated apoptosis in human T cells by novel mono- and multitarget anti-TAT/Rev/Env ribozymes and a general purpose RNA-cleaving DNA-enzyme

Antiviral Research

Volumn 72, Issue 2, 2006, Pages 134-144

  Unwalla, Hoshang ^a   Chakraborti, Samitabh ^a   Sood, Vikas ^a   Gupta, Nidhi ^a   Banerjea, Akhil C ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Apoptosis; Catalytic nucleic acids; Gene therapy; HIV

Indexed keywords

HAMMERHEAD RIBOZYME; REV PROTEIN; RIBOZYME; RNA CLEAVING DNA ENZYME; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VIRUS ENZYME;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CD4+ T LYMPHOCYTE; CELL PROTECTION; CONTROLLED STUDY; DISEASE COURSE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; VIRUS INFECTION; VIRUS INHIBITION;

ANTI-HIV AGENTS; APOPTOSIS; CELL LINE; CELLS, CULTURED; DNA, CATALYTIC; GENE EXPRESSION; GENE PRODUCTS, TAT; GENES, ENV; GENES, REV; HELA CELLS; HIV-1; HUMANS; JURKAT CELLS; MACROPHAGES; RNA, CATALYTIC; RNA, VIRAL; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33748317801     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2006.05.009     Document Type: Article

References (43)

1. Adachi A., Glendelman H.E., Koenig S., Folks T., Willey R., Rabsom A., and Martin M.A. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59 (1986) 284-291
2. Akkina R., Banerjea A., Bai J., Anderson J., Li M.J., and Rossi J.J. siRNAs, ribozymes and RNA decoys in modeling stem cell-based gene therapy for HIV/AIDS. Anticancer Res. 23 (2003) 1997-2005
3. Banerjea A.C., and Joklik W.K. Reovirus protein sigma 1 translated in vitro, as well as truncated derivatives of it that lack up to two-thirds of its C-terminal portion, exists as two major tetrameric molecular species that differ in electrophoretic mobility. Virology 179 (1990) 460-462
4. Banerjea A.C., Kedarnath N., Gore M.M., Dayaraj C., Jamkar A.V., and Ghosh S.N. Interferon (type α and γ) production by fresh and cryopreserved human mononuclear cells. Arch. Virol. 69 (1981) 91-94
5. Banerjea A., Li M.J., Bauer G., Remling L., Lee N.S., Rossi J.J., and Akkina R. Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages. Mol. Ther. 8 (2003) 62-71
6. Banerjea A.C., Chakraborti S., Unwalla H., Goila R., Basu S., Dash B.C., Sriram B., Paramasivam N., and Viswanathan S. Potential therapeutic application of DNA enzymes and siRNAs against viral and cellular genes. In: Khachigian L.M. (Ed). Synthetic Nucleic Acids as Inhibitors of Gene Expression: Mechanisms, Applications, and Therapeutic Implications (2005), CRC Press, Florida, USA 115-134
7. Banerjea A., Li M.J., Remling L., Rossi J., and Akkina R. Lentiviral transduction of Tar decoy and CCR5 ribozyme into CD34 + progenitor cells and derivation of HIV-1 resistant T cells and macrophages. AIDS Res. Ther. 1 (2004) 2
8. Berger E.A., Murphy P.M., and Farber J.M. Chemokine receptors as HIV-1 coreceptor: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17 (1999) 657-700
9. Campbell G.R., Pasquier E., Watkins J., Bourgarel-Rey V., Peyrot V., Esquieu D., Barbier P., de Mareuil J., Braguer D., Kaleebu P., Yirrel D.L., and Loret E.P. The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. J. Biol. Chem. 279 (2004) 48197-48204
10. Chakraborti S., and Banerjea A.C. Inhibition of HIV-1 gene expression by novel DNA enzymes targeted to cleave HIV-1 TAR RNA: potential effectiveness against all HIV-1 isolates. Mol. Ther. 7 (2003) 817-826
11. Chang H.C., Samaniego F., Nair B.C., Buonaguro L., and Ensoli B. HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. AIDS 11 (1997) 1421-1431
12. Chen Y. A novel single-stranded DNA expression vector. Expert Opin. Biol. Ther. 2 (2002) 735-740
13. Chun R.F., Semmes O.J., Neuveut C., and Jeang K.T. Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat. J. Virol. 72 (1998) 2615-2629
14. Coburn G.A., and Cullen B.R. Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J. Virol. 76 (2002) 9225-9231
15. Cohen S.S., Li C., Ding L., Cao Y., Pardee A.B., Shevacch E.M., and Cohen D.I. Pronounced acute immunosuppression in vivo mediated by HIV-1 Tat challenge. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 10842-10847
16. Dash B.C., and Banerjea A.C. Sequence specific cleavage activities of DNA enzymes targeted against HIV-1 Gag and Nef regions. Oligonucleotides 14 (2004) 41-47
17. Dingwall C., Ernberg I., Gait M.J., Green S.M., Heaphy S., Karn J., Lowe A.D., Singh M., and Skinner M.A. HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure. EMBO. J. 9 (1990) 4145-4153
18. Fauci A.S. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 262 (1993) 1011-1018
19. Fitzgerald M.L., Moore K.J., Freeman M.W., and Reed G.L. Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macarophages. J. Immunol. 164 (2000) 2692-2700
20. Flores O., Lee G., Kessler J., Miller M., Schlief W., Tomassini J., and Hazuda D. Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 7208-7213
21. Giacca M. HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?. Retrovirology 2 (2005) 7
22. Goila R., and Banerjea A.C. Inhibition of hepatitis B virus X gene expression by novel DNA enzymes. Biochem. J. 353 (2001) 701-708
23. Jacque J.M., Triques K., and Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature 418 (2002) 435-438
24. Jeang K.T., Berkhout B., and Dropulic B. Effects of integration and replication on transcription of the HIV-1 long terminal repeat. J. Biol. Chem. 268 (1993) 24940-24949
25. Li C.J., Friedman D.J., Wang C., Metelev V., and Pardee A.B. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science 268 (1995) 429-431
26. Lohr M., Kibler K.V., Zachary I., Jeang K.T., and Selwood D.L. Small HIV-1-Tat peptides inhibit HIV-1 replication in cultured T-cells. Biochem. Biophys. Res. Commun. 300 (2003) 609-613
27. Meyaard L., Otto S.A., Jonker R.R., Mijnster K.J., Keet R.P., and Miedema F. Programmed death of T cells in HIV-1 infection. Science 257 (1992) 217-219
28. Morris K.V., and Rossi J.J. Anti-HIV-1 gene expressing lentiviral vectors as an adjunctive therapy for HIV-1 infection. Curr. HIV Res. 2 (2004) 185-191
29. Neuveut C., and Jeang K.T. Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture. J. Virol. 70 (1996) 5572-5581
30. Neuveut C., Scoggins R.M., Camerini D., Markham R.B., and Jeang K.T. Requirement for the second coding exon of Tat in the optimal replication of macrophage-tropic HIV-1. J. Biomed. Sci. 10 (2003) 651-660
31. Ott M., Emiliani S., Van Lint S., Herbein G., Lovett J., Chirmule N., McCloskey T., Pahwa S., and Verdin E. Immune hyperactivation of HIV-1-infected T cells mediated by Tat and CD28 pathway. Science 275 (1997) 1481-1485
32. Purvis S.F., Jacobberger J.W., Sramkoski R.M., Patki A.H., and Lederman M.M. HIV type 1 Tat protein induces apoptosis and death in Jurkat cells. AIDS Res. Hum. Retroviruses 11 (1995) 443-450
33. Rossi J.J. The application of ribozymes to HIV-1 infection. Curr. Opin. Mol. Ther. 1 (1999) 316-322
34. Santoro S.W., and Joyce G.F. A general purpose RNA-cleaving DNA-enzyme. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 4262-4266
35. Shahi S., Shanmugasundaram G.K., and Banerjea A.C. Ribozymes that cleave reovirus genome S1 also protects cells from pathogenesis caused by reovirus infection. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 4101-4106
36. Smith S.M., Pentlicky S., Klase Z., Singh M., Neuveut C., Lu C.Y., Reitz Jr. M.S., Yarchoan R., Marx P.A., and Jeang K.T. An in vivo replication-important function in the second coding exon of Tat is constrained against mutation despite cytotoxic T lymphocyte selection. J. Biol. Chem. 278 (2003) 44816-44825
37. Stevenson M. HIV-1 pathogenesis. Nat. Med. 9 (2003) 853-860
38. Unwalla H., and Banerjea A.C. Inhibition of HIV-1 gene expression by novel macrophage-tropic DNA-enzymes targeted to cleave HIV-1 TAT/Rev RNA. Biochem. J. 357 (2001) 147-155
39. Vendeville A., Rayne F., Bonhoure A., Bettache N., Montcourrier P., and Beaumelle B. HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses. Mol. Biol. Cell 15 (2004) 2347-2360
40. Weissman J.D., Brown J.A., Howcroft T.K., Hwang J., Chawla A., Roche P.A., Schiltz L., Nakatani Y., and Singer D.S. HIV-1 tat binds TAFII250 and repress TAFII250-dependent transcription of major histocompatibility class 1 genes. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 11601-11606
41. Westendorp M.O., Li-Weber M., Frank R.W., and Krammer P.H. Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells. J. Virol. 68 (1994) 4177-4185
42. Xiao H., Neuveut C., Tiffany H.L., Benkirane M., Rich E.A., Murphy P.M., and Jeang K.T. Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 11466-11471
43. Yen-Moore A., Hudnall S.D., Rady P.L., Wagner R.F., Moore T.O., Memar O., Hughes T.K., and Tyring S.K. Differential expression of the HHV-8 vGCR cellular homolog gene in AIDS-associated and classic Kaposi's sarcoma: potential role of HIV-1 Tat. Virology 267 (2000) 247-251