Zinc, oxidative stress, genetic background and immunosenescence: Implications for healthy ageing

Immunity and Ageing

Volumn 3, Issue , 2006, Pages

  Mocchegiani, Eugenio ^a   Malavolta, Marco ^a   Marcellini, Fiorella ^a   Pawelec, Graham ^b  

^a INRCA   (Italy)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; BIOCHEMICAL MARKER; CATALASE; CLUSTERIN; DNA; GLUTATHIONE PEROXIDASE; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; METALLOTHIONEIN; METHIONINE SULFOXIDE REDUCTASE; METHIONINE SULFOXIDE REDUCTASE A; METHIONINE SULFOXIDE REDUCTASE B; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; RANTES; STAT PROTEIN; SUPEROXIDE DISMUTASE; TELOMERASE; TRANSCRIPTION FACTOR SP1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER;

ADENOSINE DIPHOSPHATE RIBOSYLATION; AGED; AGING; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CELLULAR IMMUNITY; CHRONIC INFLAMMATION; DNA REPAIR; EPIDEMIOLOGICAL DATA; EUROPE; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETIC STABILITY; GENETIC SUSCEPTIBILITY; HEALTH PROMOTION; HUMAN; IMMUNE RESPONSE; INDUSTRIALIZATION; LIFESTYLE; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE; SIGNAL TRANSDUCTION; SOCIAL PSYCHOLOGY; TELOMERE; TH1 CELL; TH2 CELL; THYMUS FUNCTION; ZINC BLOOD LEVEL; ZINC DEFICIENCY; ZINC METABOLISM;

EID: 33748307444     PISSN: 17424933     EISSN: None     Source Type: Journal    
DOI: 10.1186/1742-4933-3-6     Document Type: Article

References (31)

1. [http://www.zincage.org].
2. Mocchegiani E, Costarelli L, Giacconi R, Cipriano C, Muti E, Tesei S, Malavolta M: Nutrient-gene interaction in ageing and successful ageing A single nutrient (zinc) and some target genes related to inflammatory/ immune response. Mech Ageing Dev 2006, 127:517-25.
3. Kaliora AC, Dedoussis GV, Schmidt H: Dietary antioxidants in preventing atherogenesis. Atherosclerosis 2006, 187:1-17.
4. Trichopoulou A, Gnardellis C, Lagiou A, Benetou V, Trichopoulos D: Body mass index in relation to energy intake and expenditure among adults in Greece. Epidemiology 2000, 11:333-336.
5. Marcellini F, Giuli C, Papa R, Malavolta M, Mocchegiani E: Psychosocial Aspects and Zinc Status: Is There a Relationship with Successful Ageing? Rejuvenation Research 2006, 9:333-7.
6. Sensi SL, Jeng JM: Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury. Curr Mol Med 2004, 4:87-111.
7. Bürkle A, Diefenbach J, Brabeck C, Beneke S: Ageing and PARP. Pharmacol Res 2005, 52:93-99.
8. Bürkle A, Brabeck C, Diefenbach J, Beneke S: The emerging role of poly(ADP-ribose) polymerase-1 in longevity. Int J Biochem Cell Biol 2005, 37:1043-1053.
9. Jajte JM: Chemical-induced changes in intracellular redox state and in apoptosis. Int J Occup Med Environ Health 1997, 10:203-212.
10. Trougakos IP, Lourda M, Agiostratidou G, Kletsas D, Gonos ES: Differential effects of clusterin/apolipoprotein J on cellular growth and survival. Free Radic Biol Med 2005, 38:436-449.
11. Musci G, Persichini T, Casadei M, Mazzone V, Venturini G, Ponticelli F, Colasanti M: Nitrosative/oxidative modifications and ageing. Mech Ageing Dev 2006, 127:544-51.
12. Cabreiro F, Picot CR, Friguet B, Petropoulos I: Methionine sulfoxide reductases: relevance to aging and protection against oxidative stress. Ann N Y Acad Sci 2006, 1067:37-44.
13. Petropoulos I, Friguet B: Protein maintenance in aging and replicative senescence: a role for the peptide methionine sulfoxide reductases. Biochim Biophys Acta/Proteins and Proteomics 2005, 1703:261-266.
14. Soti C, Csermely P: Ageing and molecular chaperones. Exp Gerontol 2003, 10:1037-1040.
15. Soti C, Pál C, Papp B, Csermely P: Molecular chaperones as regulatory elements of cellular networks. Curr Opin Cell Biol 2005, 17:210-215.
16. Mecocci P, Polidori MC, Troiano L, Cherubini A, Cecchetti R, Pini G, Straatman M, Monti D, Stahl W, Sies H, Franceschi C, Senin U: Plasma antioxidants and longevity: a study on healthy centenarians. Free Radic Biol Med 2000, 28:1243-1248.
17. Geserick C, Tejera A, Gonzalez-Suarez E, Klatt P, Blasco MA: Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-beta signaling. Oncogene 2006 Feb 27
18. Hu HL, Forsey RJ, Blades TJ, Barratt ME, Parmar P, Powell JR: Antioxidants may contribute in the fight against ageing: an in vitro model. Mech Ageing Dev 2000, 121:217-230.
19. Larbi A, Douziech N, Dupuis G, Khalil A, Pelletier H, Guerard KP, Fulop T Jr: Age associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes. J Leucoc Biol 2004, 75:373-381.
20. Fulop T, Larbi A, Douziech N, Levesque I, Varin A, Herbein G: Cytokine receptor signalling and aging. Mech Ageing Dev 2006, 127:526-37.
21. Alberti S, Cevenini E, Ostan R, Capri M, Salvioli S, Bucci L, Ginaldi L, De Martinis M, Franceschi C, Monti D: Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4(+) T cells in humans. Mech Ageing Dev 2006, 127:560-66.
22. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A: Human immunosenescence: is it infectious? Immunol Rev 2005, 205:257-268.
23. Koch S, Solana R, Rosa OD, Pawelec G: Human cytomegalovirus infection and T cell immunosenescence. Mech Ageing Dev 2006, 127:538-43.
24. Aspinall R: T cell development, ageing and Interleukin-7. Mech Ageing Dev 2006, 127:572-8.
25. Mariani E, Meneghetti A, Neri S, Ravaglia G, Ford P, Cattini L, Facchini A: Chemokine production by natural killer cells from nonagenarians. Eur J Immunol 2002, 32:1524-1529.
26. Pulsatelli L, Meliconi R, Mazzetti I, Dolzani P, Meneghetti A, Neri S, Silvestri T, Ravaglia G, Forti P, Facchini A, Mariani E: Chemokine production by peripheral blood mononuclear cells in elderly subjects. Mech Ageing Dev 2000, 121:89-100.
27. Cakman I, Rohwer J, Schütz R-M, Kirchner H, Rink L: Dysregulation between TH1 and TH2 T cell subpopulations in elderly persons. Mech Ageing Dev 1996, 87:197-209.
28. Ibs KH, Rink L: Zinc-altered immune function. J Nutr 2003, 133:1452S-1456S.
29. Rattan SIS: Aging intervention, prevention and therapy through hormesis. J Gerontol Biol Sci 2004, 59A:705-709.
30. Caruso C, Lio D, Cavallone L, Franceschi C: Aging, longevity, inflammation, and cancer. Ann N Y Acad Sci 2004, 1028:1-13.
31. Solana R, Casado JG, Delgado E, Delarosa O, Marin J, Duran E, Pawelec G, Tarazona R: Lymphocyte activation in response to melanoma: interaction of NK-associated receptors and their ligands. Cancer Immunol Immunother 2006 Feb 17