Rapid ejaculation: A review of nosology, prevalence and treatment

International Journal of Impotence Research

Volumn 18, Issue SUPPL. 1, 2006, Pages

  Segraves, R T ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Nosology; Premature ejaculation; Rapid ejaculation; Sexual behavior; Sexual dysfunction; Treatment

Indexed keywords

ALFUZOSIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANESTHETIC AGENT; BENZOCAINE; BUSPIRONE; CITALOPRAM; CLOMIPRAMINE; EMLA; FLUOXETINE; MONOAMINE OXIDASE INHIBITOR; NEUROLEPTIC AGENT; PAROXETINE; SEROTONIN AGONIST; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SILDENAFIL; TERAZOSIN; TRICYCLIC ANTIDEPRESSANT AGENT;

ANXIETY; BEHAVIOR THERAPY; CLINICAL TRIAL; DISEASE CLASSIFICATION; DRUG INHIBITION; HUMAN; LATENT PERIOD; NEUROIMAGING; NEUROPHYSIOLOGY; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PERIPHERAL NERVOUS SYSTEM FUNCTION; PREMATURE EJACULATION; PREVALENCE; PRIORITY JOURNAL; PSYCHOTHERAPY; REVIEW; SEXUAL DYSFUNCTION; SPINAL REFLEX;

ANIMALS; EJACULATION; ERECTILE DYSFUNCTION; HUMANS; IMPOTENCE; MALE; NEUROPHYSIOLOGY; TERMINOLOGY; TERMINOLOGY AS TOPIC; TIME FACTORS;

EID: 33748305665     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901508     Document Type: Review

References (108)

1. Masters W, Williams V. Human Sexual Inadequacy. Little Brown: Boston, 1970.
2. Kaplan HS. The New Sex Therapy: Active Treatment of Sexual Dysfunctions. Brunner/Mazel: New York, 1974.
3. Segraves RT. Definitions and classifications of male sexual dysfunction. Int J Impot Res 1998; 10(Suppl 2): 554-558.
4. Rowland DL, Cooper SE, Schneider M. Defining early ejaculation for experimental and clinical investigation. Arch Sex Behav 2001; 30: 235-242.
5. Grenier G, Byers S. Rapid ejaculation: a review of conceptual etiological and treatment issues. Arch Sex Behav 1995; 24: 447-472.
6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn., DSM IV. American Psychiatric Press: Washington, DC, 1994.
7. World Health Organization. International Classification of Diseases and Related Health Problems, 10th edn. World Health Organization: Geneva, 1994.
8. Althof S, Levine S, Corty E, Stern E, Kurit D. A double-blind crossover trial of clomipramine for rapid ejaculation in 15 couples. J Clin Psych 1995; 56: 402-410.
9. Tanner BA. Two case reports on the modification of the ejaculatory response with the squeeze technique. Psychother Res Pract 1973; 10: 297-299.
10. Waldinger M. Rapid ejaculation. In: Levine S, Risen C, Althof A (eds). Handbook of Clinical Sexuality for Mental Health Professionals. Bruner-Routledge: New York, 2003, pp 257-274.
11. McMahon CG, Arbo C, Incrocci L, Erelman M, Rowland D, Stuckley B et al. Disorders of orgasm and ejaculation. In: Lue TF, Basson R, Rosen R et al. (eds). Sexual Medicine. Sexual Dysfunctions in Men and Women. Health Publications: Paris, 2004, pp 411-468.
12. Patrick D, Althof S, Pryor J, Rosen R, Rosen R, Rowland D, Ho H et al. Premature ejaculation: an observational study of men and their partners. J Sex Med 2005; 2: 358-368.
13. Kameya Y, Deguchi A, Yokota Y. Analysis of measured values of ejaculation time in healthy males. J Sex Marit Ther 1997; 23: 25-28.
14. Laumann EO, Gagnon JH, Michael RT, Michaels S. The Social Organization of Sexuality. Sexual Practices in the United States. University of Chicago Press: Chicago, 1994.
15. Dunn KM, Croft PR, Hackett GI. Sexual problems: a study of the prevalence and need for health care in the general population. Family Pract 1998; 15: 519-524.
16. Dunn KM, Croft PR, Hackett GI. Association of sexual problems with social, psychological and physical problems in men and women: a cross sectional population survey. J Epidemiol Comm Health 1999; 53: 144-148.
17. Laumann EO, Nicolosi A, Glasser D, Paik A, Gingell G, Moriera E et al. Sexual problems among men and women aged 40-80 years: prevalence and correlates identified in the Global Study of Sexual attitudes and Behaviors. Int J Impot Res 2005; 17: 39-57.
18. Richters J, Grunich A, de Visser R, Smith A, Rissel C. Sex in Australia: sexual difficulties in a representative sample of adults. Aust NZ J Publ Health 2003; 27: 164-170.
19. Nettelbladt P, Uddenberg N. Sexual dysfunction and sexual satisfaction in 58 married Swedish men. J Psychosom Res 1979; 23: 141-147.
20. Solstad K, Hertoft P. Frequency of sexual problems and sexual dysfunction in middle-aged Danish men. Arch Sex Behav 1993; 22: 51-58.
21. Haavio-Mannila E, Kontula O. Sexual Trends in the Baltic Sea Area. Family Federation of Finland: Helsinki, 2003.
22. Hendry WF, Althof A, Benson GS, Haensel S, Hull E, Kihara K et al. Male orgasmic and ejaculatory disorders. In: Jardin A, Wagner G, Khouri S et al. (eds). Erectile Dysfunction. Health Publications: Plymouth, UK, 2000, pp 479-508.
23. Waldinger MD. Male ejaculation and orgasmic disorder. In: Balon R, Segraves R (eds). Handbook of Sexual Dysfunction. Taylor & Francis: Boca Raton, Florida, 2005, pp 215-248.
24. Segraves RT. Neuropsychiatric aspects of sexual dysfunction. In: Fogel B, Schiffer R, Rao S (eds). Neuropsychiatry. Williams and Wilkins: Baltimore, 1996, pp 757-770.
25. Coolen LM, Peters HJ, Veening JG. Fos immunoreactivity in the brain following consummatory elements of sexual behavior. Brain Res 1996; 736: 67-82.
26. Cooled LM, Olivier B, Peters H, Veeening JG. Demonstration of ejaculation-induced neural activity in the male rat using 5HT1A agonist 8-OH-DPAT. Physiol Behav 1997; 62: 881-891.
27. Coolen LM, Peters HJ, Veening JG. Anatomical interrelationships of the medial preoptic area and other brain regions activated following male rat sexual behavior. J Comp Neurol 1998; 397: 421-435.
28. Heath R. Electrical self-stimulation of the brain in man. Am J Psychiatry 1963; 120: 571-577.
29. Heath R. Brain functions and behavior. J Nerv Ment Dis 1975; 160: 159-175.
30. Heath R. Pleasure and brain activity during orgasm. J Nerv ment Dis 1972; 154: 3-18.
31. Holstege G, Georgiades JR, Paans AMJ, Meiners L, van der Graaf F, Reinders A. Brain activation during human male ejaculation. J Neurosci 2003; 23: 9185-9193.
32. Robinson BW, Mishkin M. Ejaculation evoked by stimulation of the preoptic area in monkeys. Physiol Behav 1996; 1: 269.
33. Yells DP, Prendergast MA, Hendricks SE, Nakamura M. Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis. Pharmacol Biochem Behav 1994; 49: 121-127.
34. Lorrain D, Matuszewich L, Friedman RD. Extracellular serotonin in the lateral hypothalamic area is increased during the postejaculatory interval and impairs copulation. J Neurosci 1997; 17: 9361.
35. London LS. Mental Therapy: Studies in Fifty Cases. Couici-Friede: New York, 1957.
36. Tollison CD, Adams HE. Sexual Disorders. Treatment, Theory and Research. Gardner Press: New York, 1979.
37. Segraves RT, Rahman MI. Sexual disorders. In: Goldman L, Wise T, Brody D (eds). Psychiatry for Primary Care Physicians. American Medical Association: Chicago, 1998, pp 197-216.
38. Kaplan H. PE: How to Overcome Premature Ejaculation. Brunner/Mazel: New York, 1989.
39. Levine S. Helping Men to Control Ejaculation: Sexual Life-a Clinician's Guide. Plenum: New York, 1992.
40. Polonsky D. Premature ejaculation. In: Leiblum S, Rosen R (eds). Principles and Practice of Sex Therapy. Guilford: New York, 2000, pp 305-342.
41. Spiess W, Geer J, O'Donohue W. Premature ejaculation: investigation of factors in ejaculatory latency. J Abnorm Psychol 1984; 30: 242-245.
42. Strassberg D, Mahoney J, Schaugaard M, Hale E. The role of anxiety in early ejaculation: a psychophysiological model. Arch Sex Behav 1990; 19: 251-257.
43. Kockott G, Feil W, Revenstore D, Aldenhuff J, Besinger U. Symptomatology and psychological aspects of male sexual inadequacy: results of an experimental study. Arch Sex Behav 1980; 9: 477-493.
44. Figueira I, Possidente E, Marques C, Hayes K. Sexual dysfunction: a neglected complication of panic disorder and social phobia. Arch Sex Behav 2001; 30: 369-377.
45. Xin Z, Chung W, Choi Y, Seong D, Choi Y, Choi H. Penile sensitivity in patients with primary premature ejaculation. J Urol 1996; 156: 979-981.
46. Perretti A, Catalano A, Mirone V, Imbimbo C, Palmieri A et al. Neurophysiological evaluation of central-peripheral sensory and motor pudendal pathways in primary premature ejaculation. Urology 2003; 61: 623-638.
47. Fanciullacci F, Colpi GM, Beretta G, Zanollo A. Cortical evoked potentials in subjects with true premature ejaculation. Andrologia 1988; 20: 326-330.
48. Colpi GM, Fanciullacci F, Baretta G, Negri L, Zanollo A. Evoked sacral potentials in subjects with true early ejaculation. Andrologia 1986; 18: 583-589.
49. Waldinger MD. The neurobiological approach of premature ejaculation. J Urol 2002; 168: 2359-2367.
50. Nkanginieme I, Segraves RT. Neuropsychiatric aspects of sexual disorders. In: R Schiffer, S Rao, B Fofel (eds). Neuropsychiatry: Second Edition. Lippincott, Williams & Wilkins: Philadelphia, 2003, pp 338-357.
51. Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B. Effect of SSRI antidepressants on ejaculation: a double-blind randomized placebo-controlled study with fluoxetine, fluvoxamine, paroxetine and n sertraline. J Clin Psychopharmacol 2001; 21: 291-297.
52. Hong LK. Survival of the fastest: on the origin of premature ejaculation. J Sex Res 1984; 20: 109-122.
53. Screponi E, Carosa E, DiStasi S, Pepe M, Carrusa G, Janniri EA. Prevalence of chronic prostatits in men with premature ejaculation. Urology 2001; 58: 198-202.
54. Liang C, Zhang X, Hao Z, Shi H, Wang K. Prevalence of sexual dysfunction in Chinese men with chronic prostatits. BJU Int 2004; 93: 569-570.
55. Brown A. Ciprofloxacin as cure of premature ejaculation. J Sex Marital Ther 2000; 26: 351-352.
56. Simpson G, McCann B, Lowy M. Treatment of premature ejaculation after traumatic brain injury. Brain Inj 2003; 17: 723-729.
57. Kuhr C, Heiman J, Cardenas D, Bradley W, Berger R. Premature emission after spinal cord injury. J Urol 1995; 153: 429-431.
58. El-Sakka A. premature ejaculation in non-insulin dependent diabetic patients. Int J Androl 2003; 26: 329-334.
59. Holbrook J, Cohen P. Aromatase inhibition for the treatment of idiopathic hypogonadism in men with premature ejaculation. South Med J 2003; 45: 544-547.
60. Asian G, Arsian D, Cavdar C, Cavdar C, Sifil A, Camsari T. Analysis of premature ejaculation in hemodialysis patients using the International Index of Erectile Function. Urol Int 2003; 70: 59-61.
61. Semans JH. Premature ejaculation: a new approach. South Med J 1956; 46: 353-357.
62. Masters W, Johnson V. Human Sexual Inadequacy. Little Brown: Boston, 1970.
63. Kaplan H. Premature Ejaculation: Overcoming Early Ejaculation. Brunner Mazel: New York, 1989.
64. Metz M, McCarthy B. Coping with Premature Ejaculation. Harbinger: Oakland, CA, 2003.
65. Heiman J, LoPiccolo J. Clinical outcomes of sex therapy. Arch Gen Psychiatry 1983; 40: 443-449.
66. Hawton K. Treatment of sexual dysfunctions by sex therapy and other approaches. Br J Psychiatry 1995; 167: 307-314.
67. Hawton K, Catalan J. Prognostic factors in sex therapy. Behav Res Ther 1986; 24: 377-385.
68. Bancroft J, Coles L. Three years experience in a sexual problems clinic. BMJ 1976; 1: 1575-1577.
69. DeAmicis L, Goldberg D, LoPiccolo J, Friedman J, Davies L. Clinical follow-up of couples treated for sexual dysfunction. Arch Sex Behav 1985; 14: 467-489.
70. Carufel F, Trudel G. Effects of a new functional-sexological treatment for premature ejaculation. Personal communication.
71. Hamid-Abdel IA, el Naggar EA, Gilnay AH. Assessment of as needed use of pharmacotherapy and the pause squeeze technique in premature ejaculation. Int J Impot Res 2001; 13: 41-45.
72. de Carufel F. L'approche sexo-corporelle et la fonctionnalite sexuelle. Cashiers des Sciences Familiales et Sexologiques 1990; 13: 109-119.
73. Damru F. Premature ejaculation: use of ethyl aminibenzoate to prolong coitus. J Urol 1963; 89: 936-945.
74. Atikeler M, Gecit I, Senol F. Optimum usage of prilocaine-lidocaine cream in premature ejaculation. Andrologia 2002; 34: 356-359.
75. Berkovitch M, Keresteci A, Kpren G. Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. J Urol 154: 1360-1361.
76. Basuto W, Galindo C. Topical anaesthetic use for treating premature ejaculation: a double-blind randomized placebo-controlled study. BJU Int 2004; 93: 1018-1021.
77. Henry R, Morales A. Topical lidocaine-prilocaine spray for the treatment of premature ejaculation. BJU Int 2004; 93: 1018-1021.
78. Xin Z, Choi, Lee S, Choi H. Efficacy of a topical agent SS-cream in the treatment of early ejaculation: preliminary clinical studies. Yonsei Med J 1997; 38: 91-100.
79. Choi HK, Jung GW, Moon KH, Xin Z, Choi Y, Lee W. Clinical study of S-cream in patients with lifelong premature ejaculation. Urology 2000; 55: 257-261.
80. Xin Z, Choi Y, Lee W, Choi Y, Yang W, Choi H et al. Penile vibratory threshold changes with various doses of SS-cream in patients with premature ejaculation. Yonsei Med J 2000; 41: 29-33.
81. Tian L, Xin Z, Xin H, Fu Y, Yuan Y, Liu W et al. Effect of renewed SS-cream on spinal somatosensory evoked potentials in rabbits. Asian J Androl 2000; 6: 15-18.
82. Segraves RT. Efects of psychotropic drugs on human sexuality. Arch Gen Psych 1989; 46: 275-284.
83. Segraves RT. Neuropsychiatric aspects of sexual dysfunction. In: B Fogel, R Schiffer, S Rao (eds). Neuropsychiatry. Williams and Wilkins: Baltimore, 1996, pp 757-770.
84. Segraves R, Althof S. Psychotherapy and pharmacotherapy for sexual dysfunctions. In: P Nathan, J Gorman (eds). A Guide to Treatments that Work. Oxford University Press: New York, 2002, pp 497-524.
85. Monteiro WO, Noshirvani HF, Mark I. Anorgasmia from clomipramine in obsessive-compulsive disorder: a controlled trial. Br J Psychiatry 1987; 151: 107-112.
86. Althof S, Levine S, Corty E, Risen C, Stern E, Kurit D. A double blind crossover trial of clomipramine for rapid ejaculation in 15 couples. J Clin Psychiatry 1995; 56: 402-407.
87. Segraves R, Saran A, Segraves K, Maguire E. Clomipramine versus placebo in the treatment of premature ejaculation; a pilot study. J Sex Marital Ther 1993; 19: 198-200.
88. Haensel S, Rowland D, Kallan K, Slob K. Clomipramine and sexual function in men with premature ejaculation and controls. J Urol 1996; 156: 1310-1315.
89. Kara H, Aydin S, Agargun M, Odasas O, Yilmaz Y. The efficacy of fluoxetine in the treatment of premature ejaculation: a double blind placebo controlled study. J Urol 1996; 156: 1631-1632.
90. Kim S, Keun K. Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation. J Urol 1998; 159: 25-427.
91. Ludovico G, Corvasce A, Pagliarulo G, Cirillo-Marucco E, Marino A, Pagliarulo E. Paroxetine in the treatment of premature ejaculation. Br J Urol 1996; 77: 881-882.
92. McMahon C, Abdo C, Incrocci L, Perelman M, Rowland D, Waldinger M et al. Disorders of orgasm and ejaculation in men. J Sex Med 2004; 1: 58-64.
93. McMahon C, Touma K. Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol 1999; 161: 1826-1830.
94. Mendels J, Camera A, Sikes C. Sertraline treatment for premature ejaculation. J Clin Psychopharmacol 1995; 15: 341-345.
95. Strassberg D, Gouveia C, Rowland D, Tan P, Slob K. Clomipramine in the treatment of rapid (premature) ejaculation. J Sex Marit Ther 1999; 25: 89-101.
96. Waldinger M, Hengelveld W, Zwinderman A, Oliver B. Effects of SSRI antidepressants on ejaculation: a double blind randomized placebo-controlled study. J Clin Psychopharmacol 1998; 18: 274-314.
97. Waldinger M, Zwinderman A, Oliver B. Antidepressants and ejaculation: a double-blind randomized placebo-controlled fixed dose study with paroxetine, sertraline and nefazodone. J Clin Psychopharmacol 2001; 21: 293-297.
98. Waldinger M, Zwinderman A, Oliver B. SSRIs and ejaculation: a double blind randomized fixed dose study with paroxetine and citalopram. J Clin Psychopharmacol 2001; 21: 556-560.
99. Waldinger M, Hengeeveld M, Zwinderman A. Ejaculation retarding properties of paroxetine: a double blind randomized dose response study. Br J Urol 1997; 79: 592-595.
100. Yilmaz U, Tatlisen A, Turan H, Arman F, Ekmekcioglu O. The effects of fluoxetine on several neuro-physiological variables in patients with premature ejaculation. J Urol 1999; 161: 107-111.
101. Kennedy SH, Eisfeld BS, Dickens SE, Bacchiochi J, Bagby R. Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline, and venlafaxine. J Clin Psychiatry 2000; 61: 276-281.
102. Detke MJ, Wiltse CG, Mallinckrodt CH, McNamara R, Demitrach M, Bitter J. Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trial. Eur Neuropsychopharmacol 2004; 14: 457-470.
103. Montejo AL, Llorca G, Izquierdo JA. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. J Clin Psychiatry 2001; 62: 10-21.
104. Vanderkooy JD, Kennedy SH, Bagby RM. Antidepressant side effects in depression patients treated in a naturalistic setting: a study of bupropion, moclobemide, paroxetine, sertraline, and venlafaxine. Can J Psychiatry 2002; 47: 174-180.
105. Salonia A, Maga A, Colombo R. A prospective study comparing paroxetine alone to paroxetine plus sildenafil in patients with early ejaculation. J Urol 2002; 168: 2486-2490.
106. Chen J, Mabjeesh N, Matzkin H. Efficacy of sildeanfil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating early ejacalation. Urology 2003; 61: 197-203.
107. McMahon CG, Stuckley B, Andersen M, Purvis K, Koppiker N, Haughie S et al. Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation. J Sex Med 2005; 2: 368-375.
108. Cavallini G. Apha-1 blockade pharmscotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy. Eur Urol 1995; 28: 126-130.