Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios

Molecular Psychiatry

Volumn 7, Issue 9, 2002, Pages 962-966

  West, A ^a   Langley, Kate ^a   Hamshere, M L ^a   Kent, Lindsey ^b   Craddock, N ^b   Owen, M J ^a   O'Donovan, M ^a   Thapar, A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Association studies; Attention deficit hyperactivity disorder; Genetics; Molecular genetics; Transmission disequilibrium test

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CONDUCT DISORDER; FAMILY HEALTH; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HUMAN; MALE; PARENT; PHENOTYPE; PRESCHOOL CHILD; PSYCHOLOGICAL ASPECT; RISK FACTOR; BEHAVIOR; COMORBIDITY; CONTROLLED STUDY; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; MAJOR CLINICAL STUDY; MOLECULAR GENETICS; PRIORITY JOURNAL; SCORING SYSTEM; STATISTICS;

ADOLESCENT; ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD, PRESCHOOL; CONDUCT DISORDER; FAMILY HEALTH; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; PARENTS; PHENOTYPE; RISK FACTORS;

EID: 0036428850     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001129     Document Type: Article

References (25)

1. Craddock N, Owen MJ. Modern molecular genetic approaches to psychiatric disease. Br Med Bull 1996; 52: 434-452.
2. Craddock N, Dave S, Greening, J. Association studies of bipolar disorder. Bipolar Dis 2001; 3: 284-298.
3. Owen MJ, Craddock N. Modern molecular genetic approaches to complex traits: Implications for psychiatric disease. Mol Psychiatry 1996; 1: 21-26.
4. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516.
5. Sham P, Curtis D. An extended transmission/disequilibrium test (ETDT) for multi-allele marker loci. Ann Hum Genet 1995; 59: 323-336.
6. Spielman RS, Ewens WJ. A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test. Am J Hum Genet 1998; 62: 450-458.
7. Clayton D, Jones DB. Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet 2000; 65: 1161-1169.
8. Angold A, Costello EJ. The Child Adolescent Psychiatric Assessment (CAPA). J Am Acad Child Adolesc Psychiatry 2000; 39: 39-48.
9. Holmes J, Lawson DC, Pay HM, Fitzpatrick H, Trumper AL, Harrington R, Thapar A. The Child Attention Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): Reliability and Validity Findings. Unpublished data.
10. Holmes J, Payton A, Barrett JH, Hever T, Fitzpatrick H, Trumper AL et al. A family-based and case-control association study of the dopamine D4 reception gene and dopamine transporter gene in attention deficit hyperactivity disorder. Mol Psychiatry 2000; 5: 523-530.
11. Conners CK. Rating scales in attention deficit hyperactivity disorder: Use in assessment and treatment and monitoring. J Clin Psychiatry 1998; 59: 24-30.
12. Thapar A, Holmes J, Poulton K, Harrington R. Genetic basis of attention deficit and hyperactivity. Br J Psychiatry 1999; 174: 105-111.
13. Thapar A. In: Plomin R, DeFries J, Craig I, McGuffin P (eds). Behavioural Genetics in the Post-Genomic Era. APA Books (in press).
14. Sherman DK, Iacono WG, McGue MK. Attention deficit hyperactivity disorder dimensions: A twin study of inattention and impulsivity-hyperactivity. J Am Acad Child Adolesc Psychiatry 1997; 36: 745-753.
15. Hudziak JJ, Rudiger LP, Neale MC, Heath AC, Todd RD. A twin study of inattentive, aggressive and anxious/depressed behaviours. J Am Acad Child Adolesc Psychiatry 1998; 39: 469-476.
16. Faraone SV, Biederman J, Monuteaux MC. Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder. Genet Epidemiol 2000; 18: 1-16.
17. Smalley SL, McGough JJ, Del'Homme M, Newdelman J, Gordon E, Kim T et al. Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2000; 39: 1153-1143.
18. Todd RD, Rasmussen ER, Neuman RJ, Reich W, Hudziak JJ, Bucholz KK et al. Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins. Am J Psychiatry 2001; 158: 1891-1898.
19. Swanson JM, Sunohara GA, Kennedy JL, Regino R, Fineberg E, Wigal T et al. Association of the dopamine receptor D4 (DRD4) with a refined phenotype of attention deficit hyperactivity disorder (ADHD): A family-based approach. Mol Psychiatry 1998; 3: 38-41.
20. Rowe DC, Stever C, Giedinghagen LN, Gard JMC, Cleveland HH, Terris ST et al. Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder. Mol Psychiatry 1998; 3: 419-426.
21. Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL et al. Association of the dopamine transporter (DAT1) and attention deficit hyperactivity disorder in children: Heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 1998; 63: 1767-1776.
22. Thapar A, Harrington R, McGuffin P. Examining the comorbidity of ADHD related behaviours and conduct problems using a twin study design. Br J Psychiatry 2001; 179: 224-229.
23. Holmes J, Payton A, Barrett J, Harrington R, McGuffin P, Owen M et al. Association of DRD4 in children with ADHD and comorbid conduct problems. Am J Med Genet 2002; 114: 150-153.
24. Mill J, Currans S, Kent L, Richards S, Gould A, Virdee V et al. Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: Evidence of association but no linkage in a UK sample. Mol Psychiatry 2001; 6: 440-444.
25. Faraone SV, Doyle AE, Mick E, Biederman J. Meta-analysis of the association between dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder. Am J Psychiatry 2001; 158: 1052-1057.