Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5360-5363

  Arnold, Leggy A ^a   Kiplin Guy, R ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Dibenzo b,f azocine; Kinase inhibitor

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; AZOCINE DERIVATIVE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIBENZO[B,F]AZOCINE DERIVATIVE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

AZOCINES; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33748296097     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.078     Document Type: Article

References (15)

1. Kessel B.J., and Simpson M.G. In: Kaplan H.I., and Sadock B.J. (Eds). Comprehensive Textbook of Psychiatry Vol. 2 (1995), Williams and Wilkins, Baltimore 2095
2. Tardito D., Perez J., Tiraboschi E., Musazzi L., Racagni G., and Popoli M. Pharmacol. Rev. 58 (2006) 115
3. Taylor S.S., Kim C., Vigil D., Haste N.M., Yang J., Wu J., and Anand G.S. Biochim. Biophys. Acta 1754 (2005) 25
4. Newton A.C. Biochem. J. 370 (2003) 361
5. Arnold L.A., Luo W., and Guy R.K. Org. Lett. 6 (2004) 3005
6. Chijiwa T., Mishima A., Hagiwara M., Sano M., Hayashi K., Inoue T., Naito K., Toshioka T., and Hidaka H. J. Biol. Chem. 265 (1990) 5267
7. Hidaka H., Inagaki M., Kawamoto S., and Sasaki Y. Biochemistry 23 (1984) 5036
8. Engh R.A., Girod A., Kinzel V., Huber R., and Bossemeyer D. J. Biol. Chem. 271 (1996) 26157
9. Maillard M.C., Perlman M.E., Amitay O., Baxter D., Berlove D., Connaughton S., Fischer J.B., Guo J.Q., Hu L.Y., McBurney R.N., Nagy P.I., Subbarao K., Yost E.A., Zhang L., and Durant G.J. J. Med. Chem. 41 (1998) 3048
10. Ruel R., Lacombe P., Abramovitz M., Godbout C., Lamontagne S., Rochette C., Sawyer N., Stocco R., Tremblay N.M., Metters K.M., and Labelle M. Bioorg. Med. Chem. Lett. 9 (1999) 2699
11. Sum F.W., Dusza J., Santos E.D., Grosu G., Reich M., Du X., Albright J.D., Chan P., Coupet J., Ru X., Mazandarani H., and Saunders T. Bioorg. Med. Chem. Lett. 13 (2003) 2195
12. Kelly T.A., and Mcneil D.W. Tetrahedron Lett. 35 (1994) 9003
13. Gurtler C., and Buchwald S.L. Chem. Eur. J. 5 (1999) 3107
14. Littke A.F., Schwarz L., and Fu G.C. J. Am. Chem. Soc. 124 (2002) 6343
15. Mitsunobu O. Synthesis (1981) 1