Bioactivation of carbamate-based 20(S)-camptothecin prodrugs

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 8, 2004, Pages 1859-1866

  Pessah, Neta ^a   Reznik, Mika ^a   Shamis, Marina ^a   Yantiri, Ferda ^b   Xin, Hong ^b   Bowdish, Katherine ^b   Shomron, Noam ^a   Ast, Gil ^a   Shabat, Doron ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b Alexion Antibody Technologies Inc   (United States)

Author keywords

ADEPT; Enzymes; Prodrug Activation; Selective Chemotherapy

Indexed keywords

CAMPTOTHECIN DERIVATIVE; CARBAMIC ACID DERIVATIVE; CATALYTIC ANTIBODY; CATALYTIC ANTIBODY 38C2; PENICILLIN G AMIDASE; PENICILLIN G DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; BREAST ADENOCARCINOMA; CARCINOMA CELL; CELL GROWTH; CONTROLLED STUDY; DRUG SYNTHESIS; EMBRYO CELL; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; INCUBATION TIME; KIDNEY CELL; LIVER CELL CARCINOMA; MELANOMA; PANCREAS ADENOCARCINOMA; PROSTATE CANCER; UTERINE CERVIX CARCINOMA;

BIOTRANSFORMATION; CAMPTOTHECIN; CARBAMATES; CELL LINE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH INHIBITORS; HUMANS; PRODRUGS;

EID: 1642502572     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.039     Document Type: Article

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