Modulation by homocysteine of the iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells

European Journal of Pharmacology

Volumn 546, Issue 1-3, 2006, Pages 109-119

  Au, Alice L S ^a   Seto, S W ^a   Chan, S W ^a   Chan, M S ^a   Kwan, Y W ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

BKCa channel; Homocysteine; Nicotinamide adenine dinucleotide phosphate oxidase; Porcine coronary artery; Superoxide anion

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; ANGIOTENSIN II; APOCYNIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CATALASE; DIPHENYLIODONIUM SALT; HOMOCYSTEINE; IBERIOTOXIN; LUCIGENIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUPEROXIDE DISMUTASE; TIRON;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; CORONARY ARTERY; DRUG ACTIVITY; ENZYME ACTIVATION; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; SWINE;

1,2-DIHYDROXYBENZENE-3,5-DISULFONIC ACID DISODIUM SALT; ACETOPHENONES; ANGIOTENSIN II; ANIMALS; BENZIMIDAZOLES; CALCIUM; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; HOMOCYSTEINE; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; NAD; NADPH OXIDASE; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; SUPEROXIDES; SWINE; TIRON; VASOCONSTRICTOR AGENTS;

EID: 33748291565     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.06.073     Document Type: Article

References (77)

1. Arnesen E., Refsum H., Bonaa K.H., Ueland P.M., Forde O.H., and Nordrehaug J.E. Serum total homocysteine and coronary heart disease. Int. J. Epidemiol. 24 (1995) 704-709
2. Ca channels of pig coronary artery smooth muscle cells. J. Mol. Cell. Cardiol. 38 (2005) 1038 (abstract)
3. Au A.L.S., Kwan Y.W., Kwok C.C., Zhang R.Z., and He G.W. Mechanisms responsible for the in vitro relaxation of ligustrazine on porcine left anterior descending coronary artery. Eur. J. Pharmacol. 468 (2003) 199-207
4. + channels of porcine isolated left anterior descending coronary artery by diosgenin. Eur. J. Pharmacol. 502 (2004) 123-133
5. Babior B.M. NADPH oxidase: an update. Blood 93 (1999) 1464-1476
6. Bagi Z., Ungvari Z., and Koller A. Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 28-33
7. Ca channel activity. Am. J. Physiol. 275 (1998) H1283-H1289
8. Berman R.S., and Martin W. Arterial endothelial barrier dysfunction: actions of homocysteine and the hypoxanthine-xanthine oxidase free radical generating system. Br. J. Pharmacol. 108 (1993) 920-926
9. Bhunia A.K., Schwarzmann G., and Chatterjee S. GD3 recruits reactive oxygen species to induce cell proliferation and apoptosis in human aortic smooth muscle cells. J. Biol. Chem. 277 (2002) 16396-16402
10. Blom H.J., Kleinveld H.A., Boers G.H., Demacker P.N., Nak-Lemmers H.L., Te Poele-Pothoff M.T., and Trijebels J.M. Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia. Eur. J. Clin. Invest. 25 (1995) 149-154
11. Choy W.Y., Wong Y.F., Kwan Y.W., Au A.L.S., Lau W.H., Raymond K., and Zuo J.Z. Role of mitogen-activated protein kinase pathway in acetylcholine-mediated in vitro relaxation of rat pulmonary artery. Eur. J. Pharmacol. 434 (2002) 55-64
12. De Keulenaer G.W., Alexander R.W., Ushio-Fukai M., Ishizaka N., and Griendling K.K. Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle. Biochem. J. 329 (1998) 653-657
13. + channels. J. Neurosci. 17 (1997) 4942-4955
14. Eberhardt R.T., Forgione M.A., Cap A., Leopold J.A., Rudd M.A., Trolliet M., Heydrick S., Stark R., Klings E.S., Moldovan N.I., Yaghoubi M., Goldschmidt-Clermont P.J., Farber H.W., Cohen R., and Loscalzo J. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J. Clin. Invest. 106 (2000) 483-491
15. Ellmark S.H., Dusting G.J., Fui M.N., Guzzo-Pernell N., and Drummond G.R. The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Cardiovasc. Res. 65 (2005) 495-504
16. +-currents in porcine coronary arteries and adenosine sensitivity during metabolic inhibition. J. Cardiovasc. Pharmacol. 43 (2004) 495-503
17. Gobbel T.G., Chan T.Y.Y., and Chan P.H. Nitric oxide- and superoxide-mediated toxicity in cerebral endothelial cells. J. Pharmacol. Exp. Ther. 282 (1997) 1600-1607
18. Griendling K.K., Minieri C.A., Ollerenshaw J.D., and Alexander R.W. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res. 74 (1994) 1141-1148
19. Guzik T.J., West N.E.J., Black E., McDonald D., Ratnatunga C., Pillai R., and Channon K.M. Vascular superoxide production by NAD(P)H oxidase. Association with endothelial dysfunction and clinical risk factors. Circ. Res. 86 (2000) e85-e90
20. Guzik T.J., Mussa S., Gastaldi D., Sadowski J., Ratnatunga C., Pillai R., and Channon K.M. Mechanisms of increased vascular superoxide production in human diabetes mellitus. Role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 105 (2002) 1656-1662
21. Hajjar K.A. Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J. Clin. Invest. 91 (1993) 2873-2879
22. Hu Q., Corda S., Zweier J.L., Capogrossi M.C., and Ziegelstein R.C. Hydrogen peroxide induces intracellular calcium oscillations in human aortic endothelial cells. Circ. Res. 97 (1998) 268-275
23. Jakubowski H. Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels. J. Biol. Chem. 272 (1997) 1935-1942
24. Jakubowski H. Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J. Nutr. 130 (2000) 377S-381S
25. Jakubowski H. Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease. J. Biol. Chem. 277 (2002) 30425-30428
26. Kokame K., Kato H., and Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. J. Biol. Chem. 271 (1996) 29659-29665
27. Kong I.D., Koh S.D., and Sanders K.M. Purinergic activation of spontaneous transient outward currents in guinea-pig taenia colonic myocytes. Am. J. Physiol. 278 (2000) C352-C362
28. + channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats. Eur. J. Pharmacol. 365 (1999) 241-251
29. Laaksonen R., Janatuinen T., Vesalainen R., Lehtimaki T., Elovaara I., Jaakkola O., Jokela H., Laakso J., Nuutila P., Punnonen K., Raitakari O., Saikku P., Salminen K., and Knuuti J. High oxidized LDL and elevated plasma homocysteine contribute to the early reduction of myocardial flow reserve in healthy adults. Eur. J. Clin. Invest. 32 (2002) 795-802
30. Lassegue B., Sorescu D., Szocs K., Yin Q., Akers M., Zhang Y., Grant S.L., Lambeth J.D., and Griendling K.K. Novel gp91phox homologues in vascular smooth muscle cells: nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signalling pathways. Circ. Res. 88 (2001) 888-894
31. + channels in pulmonary arterial smooth muscle cells of the rabbit. Pflügers Arch. 427 (1994) 378-380
32. Li Y.B., Zhu H., Kuppusamy P., Roubaud V., Zweier J.L., and Trush M.A. Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J. Biol. Chem. 273 (1998) 2015-2023
33. - production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. J. Biol. Chem. 276 (2001) 29251-29256
34. + channels in coronary arterial smooth muscle cells in Zucker diabetic fatty rats. Diabetes 54 (2005) 2155-2163
35. Malinow M.R., Ducimetiere P., Luc G., Evans A.E., Arveiler D., Cambien F., and Upson B.M. Plasma homocyst(e)ine levels and graded risk for myocardial infarction. Atherosclerosis 126 (1996) 27-34
36. + channel in cultured vascular smooth muscle cells. J. Mol. Cell. Cardiol. 26 (1994) 1487-1495
37. 2 production via NADH-derived superoxide. Am. J. Physiol. 270 (1996) H1044-H1053
38. Mujumdar V.S., Hayden M., and Tyagi S.C. Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells. J. Cell. Physiol. 183 (2000) 28-36
39. Ndiaye M., Chataigneau T., Andriantsitohaina R., Stoclet J.C., and Schini-Kerth V.B. Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism. Biochem. Biophys. Res. Commun. 310 (2003) 371-377
40. Nygard O., Nordrehaug J.E., Refsum H., Ueland P.M., Farstad M., and Vollset S.E. Plasma homocysteine levels and mortality in patients with coronary artery disease. N. Eng. J. Med. 337 (1997) 230-236
41. Ody C., and Junod A.F. Direct toxic effects of paraquat and oxygen on cultured endothelial cells. Lab. Invest. 52 (1985) 77-84
42. Oeckler R.A., and Wolin M.S. Stretch enhances contractile responses in bovine coronary and pulmonary arteries: potential role of NADH oxidase-derived peroxide and activation of the ERK MAP kinase cascade. Circulation 104 (2001) II-605
43. Oeckler R.A., Kaminski P.M., and Wolin M.S. Stretch enhances contraction of bovine coronary arteries via an NAD(P)H oxidase-mediated activation of the extracellular signal-regulated mitogen-activated protein kinase cascade. Circ. Res. 92 (2003) 23-31
44. Oeckler R.A., Arcuino E., Ahmad M., Olson S.C., and Wolin M.S. Cytosolic NADH redox and thiol oxidation regulate pulmonary arterial force through ERK MAP kinase. Am. J. Physiol. 288 (2005) L1017-L1025
45. Okatani Y., Wakatsuki A., and Reiter R.J. Melatonin counteracts potentiation by homocysteine of KCl-induced vasoconstriction in human umbilical artery: relation to calcium influx. Biochem. Biophys. Res. Commun. 280 (2001) 940-944
46. Pacher P., Ungvari Z., and Kecskemeti V. Electrophysiological effects of homocysteine in isolated rat right ventricular papillary muscle and left atria. Gen. Pharmacol. 32 (1999) 439-443
47. Park M.K., Lee S.H., Lee S.J., Ho W.K., and Earm Y.E. Different modulation of Ca-activated K channels by the intracellular redox potential in pulmonary and ear arterial smooth muscle cells of the rabbit. Pflügers Arch. 430 (1995) 308-314
48. + channels and nitrergic responses in the murine colon. Br. J. Pharmacol. 144 (2005) 1126-1137
49. Rajagopalan S., Kurz S., Munzel T., Tarpey M., Freeman B.A., Griendling K.K., and Harrison D.G. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: contribution to alterations of vasomotor tone. J. Clin. Invest. 97 (1996) 1916-1923
50. Ramaswami G., Chai H., Yao Q., Lin P.H., Lumsden A.B., and Chen C. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J. Vasc. Surg. 40 (2004) 1216-1222
51. Rhoades R.A., Packer C.S., Roepke D.A., Jin N., and Meiss R.A. Reactive oxygen species alter contractile properties of pulmonary arterial smooth muscle. Can. J. Physiol. Pharm. 68 (1990) 1581-1589
52. Robinson K., Mayer E.L., Miller D.P., Green R., van Lente F., Gupta A., Kottke-Marchant K., Savon S.R., Selhub J., Nissen S.E., Kutner M., Topol E.J., and Jacobsen D.W. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation 92 (1995) 2825-2830
53. 2+ pump in pig coronary artery endothelium and smooth muscle. Cell Calcium 36 (2004) 77-82
54. Schmitz C., Lindpaintner K., Verhoef P., Gaziano J.M., and Buring J. Genetic polymorphism of methylene tetrahydrofolate reductase and myocardial infarction: a case-control study. Circulation 94 (1996) 1812-1814
55. - and NO. Am. J. Physiol. 279 (2000) F302-F308
56. Shen J.Z., Seye C.I., Wang M.F., Weisman G.A., Wilden P.A., and Sturek M. Cloning, up-regulation, and mitogenic role of porcine P2Y2 receptor in coronary artery smooth muscle cells. Mol. Pharmacol. 66 (2004) 1265-1274
57. + currents by homocysteine in rat ventricular myocytes. J. Cardiovasc. Electrophysiol. 12 (2001) 175-182
58. Skatchkov M.P., Sperling D., Hink U., Mulsch A., Harrison D.G., Sindermann I., Meinertz T., and Munzel T. Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production. Biochem. Biophys. Res. Commun. 254 (1999) 319-324
59. Stampfer M.J., Malinow M.R., Willett W.C., Newcomer L.M., Upson B., Ullmann D., Tishler P.V., and Hennekens C.H. A prospective study of plasma homocysteine and risk of myocardial infarction in U.S. physicians. JAMA 268 (1992) 877-881
60. Starkerbaum G., and Harlan J.M. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J. Clin. Invest. 77 (1986) 1370-1376
61. Suematsu M., Schmid-Schonbein G.W., Chavez-Chavez R.H., Yee T.T., Tamatani T., Miyasaka M., Delano F.A., and Zweifach B.W. In vivo visualization of oxidative changes in microvessels during neutrophil activation. Am. J. Physiol. 264 (1993) H881-H891
62. Symons J.D., Mullick A.E., Ensunsa J.L., Ma A.A., and Rutledge J.C. Hyperhomocysteinemia evoked by folate depletion. Effects of coronary and carotid arterial function. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 772-780
63. + channels in the function of rat aortic smooth muscle cells. Br. J. Pharmacol. 143 (2004) 303-317
64. Thollon C., Fournet-Bourguignon M.P., Saboureau D., Lesage L., Reure H., Vanhoutte P.M., and Vilaine J.P. Consequences of reduced production of NO on vascular reactivity of porcine coronary arteries after angioplasty: importance of EDHF. Br. J. Pharmacol. 136 (2002) 1153-1161
65. Thuringer D., and Findlay I. Contrasting effects of intracellular redox couples on the regulation of maxi-K channels in isolated myocytes from rabbit pulmonary artery. J. Physiol. 500 (1997) 583-592
66. Toro L., Amador M., and Stefani E. Ang II inhibits calcium-activated potassium channels from coronary artery smooth muscle in lipid bilayers. Am. J. Physiol. 258 (1990) H912-H915
67. Tsen C.M., Hsieh C.C., Yen C.H., and Lau Y.T. Homocyteine altered ROS generation and NO accumulation in endothelial cells. Chin. J. Physiol. 46 (2003) 129-136
68. Tyagi S.C., Smiley L.M., Mujumdar V.S., Clonts B., and Parker J.L. Reduction-oxidation (Redox) and vascular tissue level of homocyst(e)ine in human coronary atherosclerotic lesions and role in extracellular matrix remodeling and vascular tone. Mol. Cell. Biochem. 181 (1998) 107-116
69. Ueland P.M., Refsum H., Stabler S.P., Malinow M.R., Andersson A., and Allen R.H. Total homocysteine in plasma or serum: methods and clinical applications. Clin. Chem. 39 (1993) 1764-1779
70. i and constrictor responses of isolated arterioles. J. Cardiovasc. Pharmacol. 37 (2001) 705-712
71. Ungvari Z., Csiszar A., Edwards J.G., Kaminski P.M., Wolin M.S., Kaley G., and Koller A. Increased superoxide production in coronary arteries in hyperhomocysteinemia. Role of tumor necrosis factor-α, NAD(P)H oxidase, and inducible nitric oxide synthase. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 418-424
72. 12, and folate. Am. J. Epidemiol. 143 (1996) 845-859
73. Wald N.J., Watt H.C., Law M.R., Weir D.G., McPartlin J., and Scott J.M. Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention. Arch. Intern. Med. 158 (1998) 862-867
74. + channels in smooth muscle cells. J. Gen. Physiol. 110 (1997) 35-44
75. Zagorac D., Yamaura K., Zhang C., Roman R.J., and Harder D.R. The effect of superoxide anion on autoregulation cerebral blood flow. Stroke 36 (2005) 2589-2594
76. Zhang X., Li H., Jin H., Ebin Z., Brodsky S., and Goligorsky M.S. Effects of homocysteine on endothelial nitric oxide production. Am. J. Physiol. 279 (2000) F671-F678
77. Zhang H.S., Xiao J.H., Cao E.H., and Qin J.F. Homocysteine inhibits store-mediated calcium entry in human endothelial cells: evidence for involvement of membrane potential and action cytoskeleton. Mol. Cell. Biochem. 269 (2005) 37-47