Aza-stilbenes as potent and selective c-RAF inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5378-5383

  McDonald, Octerloney ^a   Lackey, Karen ^a   Davis Ward, Ronda ^a   Wood, Edgar ^a   Samano, Vicente ^a   Maloney, Patrick ^a   Deanda, Felix ^a   Hunter, Robert ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Aza stilbene; c RAF; Kinase

Indexed keywords

GW 5074; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN C RAF; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; SORAFENIB; SORFENIB; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AZA COMPOUNDS; BINDING SITES; ENZYME ACTIVATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-RAF; STEREOISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748286771     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.063     Document Type: Article

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