Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia

European Journal of Preventive Cardiology

Volumn 13, Issue 3, 2006, Pages 464-466

  Roest, Mark ^a   Rodenburg, Jessica ^b   Wiegman, Albert ^b   Kastelein, John J p ^b   Voorbij, Hieronymus A m ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

atherosclerosis; familial hypercholesterolaemia; paraoxonase (PON) 1 genotype

Indexed keywords

ARYLDIALKYLPHOSPHATASE; ARYLDIALKYLPHOSPHATASE 1; ARYLDIALKYLPHOSPHATASE 2; UNCLASSIFIED DRUG;

ADOLESCENT; ALLELE; ARTERY INTIMA; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; COMMON CAROTID ARTERY; COMPARATIVE STUDY; CONTROLLED STUDY; FAMILIAL HYPERCHOLESTEROLEMIA; GENE LOCUS; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; ONSET AGE; PEDIATRICS; POPULATION RESEARCH; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS;

ADOLESCENT; ARYLDIALKYLPHOSPHATASE; ATHEROSCLEROSIS; CAROTID ARTERIES; CHILD; GENOTYPE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS; TUNICA INTIMA;

EID: 33748278027     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1097/01.hjr.0000214615.37232.b9     Document Type: Article

References (14)

1. Mackness MI, Mackness B, Durrington PN, Fogelman AM, Berliner J, Lusis AJ, et al. Paraoxonase and coronary heart disease. Curr Opin Lipidol 1998; 9: 319–324.
2. Shih DM, Xia YR, Wang XP, Miller E, Castellani LW, Subbanagounder G, et al. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J Biol Chem 2000; 275: 17527–17535.
3. Mackness B, Durrington P, McElduff P, Yarnell J, Azam N, Watt M, Mackness M. Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study. Circulation 2003; 107: 2775–2779.
4. Durrington PN, Mackness B, Mackness MI. Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol 2001; 21: 473–480.
5. Wheeler JG, Keavney BD, Watkins H, Collins R, Danesh J. Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. Lancet 2004; 363: 689–695.
6. Leviev I, James RW. Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations. Arterioscler Thromb Vasc Biol 2000; 20: 516–521.
7. Wiegman A, de Groot E, Hutten BA, Rodenburg J, Gort J, Bakker HD, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. Lancet 2004; 363: 369–370.
8. Leus FR, Zwart M, Kastelein JJ, Voorbij HA. PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients. Atherosclerosis 2001; 154: 641–649.
9. Wiegman A, Hutten BA, de Groot E, Rodenburg J, Bakker HD, Buller HR, et al. Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial. JAMA 2004; 292: 331–337.
10. Roest M, Jansen AC, Barendrecht A, Leus FR, Kastelein JJ, Voorbij HA. Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia. Clin Biochem 2005; 38: 123–127.
11. Schmidt H, Schmidt R, Niederkorn K, Gradert A, Schumacher M, Watzinger N, et al. Paraoxonase PON1 polymorphism leu-Met54 is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study. Stroke 1998; 29: 2043–2048.
12. Malin R, Loimaala A, Nenonen A, Mercuri M, Vuori I, Pasanen M, et al. Relationship between high-density lipoprotein paraoxonase gene M/L55 polymorphism and carotid atherosclerosis differs in smoking and nonsmoking men. Metabolism 2001; 50: 1095–1101.
13. James RW, Leviev I, Ruiz J, Passa P, Froguel P, Garin MC. Promoter polymorphism T(−107)C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients. Diabetes 2000; 49: 1390–1393.
14. Marenberg ME, Risch N, Berkman LF, Floderus B, de Faire U. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 1994; 330: 1041–1046.