Promoter polymorphism T(-107)C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients

Diabetes

Volumn 49, Issue 8, 2000, Pages 1390-1393

  James, R W ^a   Leviev, I ^a   Ruiz, J ^a   Passa, P ^a   Froguel, P ^a   Garin, M C B ^a  

^a UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLDIALKYLPHOSPHATASE; GENE PRODUCT; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ALLELE; ARTICLE; DIABETIC ANGIOPATHY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RISK FACTOR;

EID: 0033856076     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.8.1390     Document Type: Article

References (20)

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2. Protective effect of high-density lipoprotein associated paraoxonase: Inhibition of the biological activity of minimally oxidized low-density lipoprotein
3. Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q-R genetic polymorphism
4. Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model
5. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
6. Atherosclerosis: Basic mechanisms: Oxidation, inflammation, and genetics
7. Atherosclerosis: An inflammatory disease
8. Paraoxonase polymorphism Met-Len54 is associated with modified serum concentrations of the enzyme: A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes
9. Two alleles of the human paraoxonase gene produce different amounts of mRNA: An explanation for differences in serum concentrations of paraoxonase associated with the (Leu-Met54) polymorphism
10. Promoter polymorphisms of the human paraoxonase PON1 gene and serum paraoxonase activities and concentrations
11. The polymorphism (Gln-Arg192) of the high-density lipoprotein-bound enzyme paraoxonase is an independent cardiovascular risk factor in non-insulin dependent diabetic patients
12. The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes
13. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
14. Auto-oxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose
15. Lipid advanced glycosylation: Pathway for lipid oxidation in vitro
16. A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary heart disease
17. Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese non-insulin-dependent diabetic patients
18. Paraoxonase 192 Gln/Arg gene polymorphism, coronary artery disease, and myocardial infarction in type 2 diabetes
19. The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with risk of coronary artery disease in Finns