Effect of sodium hydroxybutyrate on the expression of hippocampal N-methyl-D-aspartate receptor 2b subunit mRNA in neonatal rats with hypoxic-ischemic insult

Annals of Clinical and Laboratory Science

Volumn 36, Issue 3, 2006, Pages 307-311

  Ma, Zheng Liang ^a   Gu, Xiao Ping ^a   Zeng, Yin Ming ^b   Zhang, Yan ^b  

^a NANJING UNIVERSITY   (China)

^b XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Carotid ligation; Hippocampus; Hydroxybutyrate; Hypoxia; Ischemia; mRNA; N methyl D aspartate receptors; Rat brain

Indexed keywords

MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; OXYBATE SODIUM; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CAROTID ARTERY LIGATION; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HIPPOCAMPUS; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; RNA ANALYSIS;

ANIMALS; ANIMALS, NEWBORN; CAROTID ARTERIES; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SODIUM OXYBATE;

EID: 33748262498     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Horak M, Vlcek K, Chodounska H, Vyklicky L Jr. Subtype-dependence of N-methyl-d-aspartate receptor modulation by pregnenolone sulfate. Neuroscience 2006;137:93-102.
2. Loftis JM, Janowsky A. The N-methyl-d-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications. Pharmacol Ther 2003;97:55-85.
3. Zhong J, Carrozza DP, Williams K, Pritchett DB, Molinoff PB. Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J Neurochem 1995;64:531-539.
4. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ. Genetic enhancement of learning and memory in mice. Nature 1999;401:63-69.
5. Rice JE, Vannucci RC, Brierley JB. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981;9:131-141.
6. Sans N, Petralia RS, Wang YX, Blahos J 2nd, Hell JW, Wenthold RJ. A developmental change in NMDA receptor-associated proteins at hippocampal synapses. J Neurosci 2000;20:1260-1271.
7. Gurd JW, Bissoon N, Beesley PW, Nakazawa T, Yamamoto T, Vannucci SJ. Differential effects of hypoxia-ischemia on subunit expression and tyrosine phosphorylation of the NMDA receptor in 7- and 21-day-old rats. J Neurochem 2002;82:848-856.
8. Zhang L, Hus HC, Takagi N, et al. Transient global ischemia alters NMDA receptor expression in rat hippocampus: correlation with decreased immunoreactive protein levels of the NR2A/B subunits and an altered NMDA receptor functionality. J Neurochem 1997;69:1983-1994.
9. Lu W, Man H, Ju W, Trimble WS, MacDonald JF, Wang YT. Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron 2001;29:243-254.
10. Qu M, Mittman T, Luhmann HJ. Long-term changes of ionotropic glutamate and GABA receptors after unilateral permanent focal cerebral ischemia in the mouse brain. Neuroscience 1998;85:29-43.
11. Madden KP. Effect of γ-aminobutyric acid modulation on neuronal ischemia in rabbits. Stroke 1994;25:2271.
12. Enz R, Cutting GR. Molecular composition of GABAc receptors. Vision Res 1998;38:1431-1441.
13. Nissbrandt H, Elverfors A, Engberg G. Pharmacologically induced cessation of burst activity in nigral dopamine neurons: significancce for the terminal dopamine efflux. Synapse 1994;17:217-224.
14. Maitre M. The gamma-hydroxybutyrate signaling system in brain: organization and functional implication. Prog Neurobiol 1997;51:337-361.