Dietary related plasma vitamin C concentration has no effect on anticoagulation response to warfarin

Thrombosis Research

Volumn 118, Issue 4, 2006, Pages 501-504

  Wynne, Hilary ^a   Khan, Tayyaba ^b   Avery, Peter ^b   Wood, Peter ^b   Ward, Alan ^b   Kamali, Farhad ^b  

^a ROYAL VICTORIA INFIRMARY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Anticoagulation; Vitamin C; Warfarin

Indexed keywords

ASCORBIC ACID; PHYTOMENADIONE OXIDE; VITAMIN K GROUP; WARFARIN;

ADULT; AGED; ANTICOAGULATION; ARTERY DISEASE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEEP VEIN THROMBOSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; HEART ATRIUM FIBRILLATION; HEART VALVE REPLACEMENT; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; ASCORBIC ACID; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; STEREOISOMERISM; WARFARIN;

EID: 33748190246     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2005.07.017     Document Type: Article

References (20)

1. Kamali F., Khan T.I., King B.P., Frearson R., Kesteven P., Wood P., et al. Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin. Clin Pharm Ther 75 (2004) 204-212
2. Rost S., Fregin A., and Ivaskevicius V. Mutations in VKORCI cause warfarin resistance and multiple coagulation factor deficiencies type 2. Nature 427 (2004) 537-541
3. Kamali F., Edwards C., Butler T.J., and Wynne H.A. The influence of (R)- and (S)-warfarin, vitamin K and vitamin K epoxide upon warfarin anticoagulation. Thromb Haemost 84 (2000) 39-42
4. Sigell L.T., and Flessa H.C. Drug interactions with anticoagulants. JAMA 214 (1970) 2035
5. Rosenthal G. Interactions of ascorbic acid and warfarin. JAMA 215 (1971) 1671
6. Smith E.C., Skalski R.J., Johnson G.C., and Rossi G.V. Interaction of ascorbic acid and warfarin. JAMA 221 (1972) 1166
7. Hume R., Johnstone J.M.S., and Weyers E. Interaction of ascorbic acid and warfarin. JAMA 219 (1972) 1479
8. Khan T., Wynne H., Wood P., Torrance A., Hankey C., Avery P., et al. Dietary vitamin K influences intra-individual variability in anticoagulant response to warfarin. Br J Haematol 124 (2004) 348-354
9. Naidong W., and Lee J.W. Development and validation of a high performance liquid chromatographic method for the quantitation of warfarin enantiomers in human plasma. J Pharm Biomed Anal 11 (1993) 785-792
10. Davidson K.W., and Sadowski J.A. Determination of vitamin K compounds in plasma or serum by high performance liquid chromatrography using post column chemical reduction and fluorimetric detection. Methods Enzymol 282 (1997) 408-421
11. Lykkesfeldt J. Determination of ascorbic acid and dehydroascorbic acid in biological samples by high performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride. Anal Biochem 282 89 (2000) 89-93
12. DuBois D., and DuBois E.F. A formula to estimate the approximate surface area if height and weight be known. Arch Int Med 17 (1916) 863-867
13. Rowland M., and Tozer T.N. Multiple dose regimens. In: Rowland M., and Tozer T.N. (Eds). Clinical pharmacokinetics, concepts and implications. 3rd ed. (1995), Williams and Wilkins, Baltimore (MD) 83-105
14. Kallner A., Hartmann D., and Hornig D. Steady-state turnover and body pool of ascorbic acid in man. Am J Clin Nutr 32 (1979) 530-539
15. Dedichen J. The effect of ascorbic acid given to patients on chronic anticoagulant therapy. Boll Soc Ital Cardiol 18 (1973) 690-692
16. Feetam C.L., Leach R.H., and Meynell M.J. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 31 (1975) 544-547
17. 1 - methylenebis - (4-hydroxy-coumarin) in the guinea pig. J Biol Chem 151 (1943) 477-485
18. Deckert F.W. Ascorbic acid and warfarin. JAMA 223 (1973) 440
19. Weintraub M., and Griner P.F. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 28 (1974) 53-56
20. McCance RA, Widdowson EM. McCance and Widdowson's The Composition of Foods. 5th edn. Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food, Cambridge, UK; 1991.