Better identification of patients who benefit from implantable cardioverter defibrillators by genotyping the G protein β3 subunit (GNB3) C825T polymorphism

Basic Research in Cardiology

Volumn 101, Issue 5, 2006, Pages 447-451

  Wieneke, Heinrich ^a   Naber, Christoph N ^a   Piaszek, Leon ^a   Sack, Stefan ^a   Frey, Ulrich H ^b   Heusch, Gerd ^b   Erbel, Raimund ^a   Siffert, Winfried ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

G protein beta3 subunit 825T allele; GNB3 polymorphism; Implantable Cardioverter Defibrillator; Risk stratification; Ventricular arrhythmia

Indexed keywords

AMIODARONE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYTOSINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA3 SUBUNIT; SOTALOL; THYMINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DEFIBRILLATOR; DISEASE SEVERITY; FATALITY; FEMALE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HETEROZYGOTE; HIGH RISK PATIENT; HOMOZYGOTE; HUMAN; ISCHEMIC HEART DISEASE; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PILOT STUDY; PRIMARY PREVENTION; PROBABILITY; QRS COMPLEX; RISK ASSESSMENT; SECONDARY PREVENTION; STATISTICAL SIGNIFICANCE;

ADULT; AGED; ARRHYTHMIA; ARRHYTHMIAS, CARDIAC; DEFIBRILLATORS, IMPLANTABLE; ELECTROCARDIOGRAPHY; FEMALE; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; POLYMORPHISM, GENETIC;

EID: 33748079774     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-006-0600-9     Document Type: Article

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