Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q

Annals of Human Genetics

Volumn 70, Issue 6, 2006, Pages 738-748

  Shah, S H ^a   Kraus, W E ^a   Crossman, D C ^b   Granger, C B ^a   Haines, J L ^c   Jones, C J H ^d   Mooser, V ^e   Huang, L ^a   Haynes, C ^a   Dowdy, E ^a   Vega, G L ^f   Grundy, S M ^f   Vance, J M ^a   Hauser, Elizabeth R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e GLAXOSMITHKLINE   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Complex genetic traits; Coronary arteriosclerosis; Linkage mapping; Lipids; Phenotype; Quantitative trait linkage

Indexed keywords

HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 3Q; CHROMOSOME 5Q; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FAMILY; FEMALE; GENE IDENTIFICATION; HUMAN; LINKAGE ANALYSIS; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; RISK FACTOR; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 5; CORONARY ARTERIOSCLEROSIS; CORONARY ARTERY DISEASE; FEMALE; GENETIC LINKAGE; GENETIC VARIATION; HUMANS; LINKAGE (GENETICS); LIPOPROTEINS; LOD SCORE; MALE; MIDDLE AGED; PHENOTYPE; QUANTITATIVE TRAIT LOCI; VARIATION (GENETICS);

EID: 33748079202     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2006.00288.x     Document Type: Article

References (42)

1. AHA American Heart Association website: http://www.americanheart.org.
2. Almasy, L. & Blangero, J. (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62, 1198-1211.
3. Blangero, J., Williams, J. T. & Almasy, L. (2000) Robust LOD scores for variance component-based linkage analysis. Genet Epidemiol 19 (Suppl 1), S8-S14.
4. Breslow, J. L. (2000) Genetics of lipoprotein abnormalities associated with coronary artery disease susceptibility. Annu Rev Genet 34, 233-254.
5. Broeckel, U., Hengstenberg, C., Mayer, B., Holmer, S., Martin, L. J., Comuzzie, A. G., Blangero, J., Nurnberg, P., Reis, A., Riegger, G. A., Jacob, H. J. & Schunkert, H. (2002) A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet 30, 210-214.
6. Broman, K. W. (2001) Estimation of allele frequencies with data on sibships. Genet Epidemiol 20, 307-315.
7. Chiodini, B. D. & Lewis, C. M. (2003) Meta-analysis of 4 coronary heart disease genome-wide linkage studies confirms a susceptibility locus on chromosome 3q. Arterioscler Thromb Vasc Biol 23, 1863-1868.
8. Coon, H., Eckfeldt, J. H., Leppert, M. F., Myers, R. H., Arnett, D. K., Heiss, G., Province, M. A. & Hunt, S. C. (2002) A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study. Hum Genet 111, 263-269.
9. Coon, H., Leppert, M. F., Eckfeldt, J. H., Oberman, A., Myers, R. H., Peacock, J. M., Province, M. A., Hopkins, P. N. & Heiss, G. (2001) Genome-wide linkage analysis of lipids in the Hypertension Genetic Epidemiology Network (HyperGEN) Blood Pressure Study. Arterioscler Thromb Vasc Biol 21, 1969-1976.
10. Coon, H., Leppert, M. F., Kronenberg, F., Province, M. A., Myers, R. H., Arnett, D. K., Eckfeldt, J. H., Heiss, G., Williams, R. R. & Hunt, S. C. (1999) Evidence for a major gene accounting for mild elevation in LDL cholesterol: The NHLBI Family Heart Study. Ann Hum Genet 63 (Pt 5), 401-412.
11. Duggirala, R., Blangero, J., Almasy, L., Dyer, T. D., Williams, K. L., Leach, R. J., O'Connell, P. & Stern, M. P. (2000) A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Am J Hum Genet 66, 1237-1245.
12. Francke, S., Manraj, M., Lacquemant, C., Lecoeur, C., Lepretre, F., Passa, P., Hebe, A., Corset, L., Yan, S. L., Lahmidi, S., Jankee, S., Gunness, T. K., Ramjuttun, U. S., Balgobin, V., Dina, C. & Froguel, P. (2001) A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum Mol Genet 10, 2751-2765.
13. Friedewald, W. T., Levy, R. I. & Fredrickson, D. S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18, 499-502.
14. Genest, J. J., Jr., Martin-Munley, S. S., McNamara, J. R., Ordovas, J. M., Jenner, J., Myers, R. H., Silberman, S. R., Wilson, P. W., Salem, D. N. & Schaefer, E. J. (1992) Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation 85, 2025-2033.
15. Hall, J. M., Lee, M. K., Newman, B., Morrow, J. E., Anderson, L. A., Huey, B. & King, M. C. (1990) Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 1684-1689.
16. Harrap, S. B., Zammit, K. S., Wong, Z. Y., Williams, F. M., Bahlo, M., Tonkin, A. M. & Anderson, S. T. (2002) Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2. Arterioscler Thromb Vasc Biol 22, 874-878.
17. Hauser, E. R., Crossman, D. C., Granger, C. B., Haines, J. L., Jones, C. J., Mooser, V., Mcadam, B., Winkelmann, B. R., Wiseman, A. H., Muhlestein, J. B., Bartel, A. G., Dennis, C. A., Dowdy, E., Estabrooks, S., Eggleston, K., Francis, S., Roche, K., Clevenger, P. W., Huang, L., Pedersen, B., Shah, S., Schmidt, S., Haynes, C., West, S., Asper, D., Booze, M., Sharma, S., Sundseth, S., Middleton, L., Roses, A. D., Hauser, M. A., Vance, J. M., Pericak-Vance, M. A. & Kraus, W. E. (2004a) A genomewide scan for early-onset coronary artery disease in 438 families: The GENECARD Study. Am J Hum Genet 75, 436-447.
18. Hauser, E. R., Mooser, V., Crossman, D. C., Haines, J. L., Jones, C. H., Winkelmann, B. R., Schmidt, S., Scott, W. K., Roses, A. D., Pericak-Vance, M. A., Granger, C. B. & Kraus, W. E. (2003) Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study. Am Heart J 145, 602-613.
19. Hauser, E. R., Watanabe, R. M., Duren, W. L., Bass, M. P., Langefeld, C. D. & Boehnke, M. (2004b) Ordered subset analysis in genetic linkage mapping of complex traits. Genet Epidemiol 27, 53-63.
20. Imperatore, G., Knowler, W. C., Pettitt, D. J., Kobes, S., Fuller, J. H., Bennett, P. H. & Hanson, R. L. (2000) A locus influencing total serum cholesterol on chromosome 19p: Results from an autosomal genomic scan of serum lipid concentrations in Pima Indians. Arterioscler Thromb Vasc Biol 20, 2651-2656.
21. Khot, U. N., Khot, M. B., Bajzer, C. T., Sapp, S. K., Ohman, E. M., Brener, S. J., Ellis, S. G., Lincoff, A. M. & Topol, E. J. (2003) Prevalence of conventional risk factors in patients with coronary heart disease. Jama 290, 898-904.
22. Kissebah, A. H., Sonnenberg, G. E., Myklebust, J., Goldstein, M., Broman, K., James, R. G., Marks, J. A., Krakower, G. R., Jacob, H. J., Weber, J., Martin, L., Blangero, J. & Comuzzie, A. G. (2000) Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A 97, 14478-14483.
23. Kong, A. & Cox, N. J. (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61, 1179-1188.
24. Lehto, S., Ronnemaa, T., Haffner, S. M., Pyorala, K., Kallio, V. & Laakso, M. (1997) Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM. Diabetes 46, 1354-1359.
25. Mahaney, M. C., Blangero, J., Rainwater, D. L., Comuzzie, A. G., Vandeberg, J. L., Stern, M. P., Maccluer, J. W. & Hixson, J. E. (1995) A major locus influencing plasma high-density lipoprotein cholesterol levels in the San Antonio Family Heart Study. Segregation and linkage analyses. Arterioscler Thromb Vasc Biol 15, 1730-1739.
26. Marenberg, M. E., Risch, N., Berkman, L. F., Floderus, B. & De Faire, U. (1994) Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 330, 1041-1046.
27. Mori, Y., Otabe, S., Dina, C., Yasuda, K., Populaire, C., Lecoeur, C., Vatin, V., Durand, E., Hara, K., Okada, T., Tobe, K., Boutin, P., Kadowaki, T. & Froguel, P. (2002) Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 51, 1247-1255.
28. North, K. E., Miller, M. B., Coon, H., Martin, L. J., Peacock, J. M., Arnett, D., Zhang, B., Province, M., Oberman, A., Blangero, J., Almasy, L., Ellison, R. C. & Heiss, G. (2005) Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q. Atherosclerosis 179, 119-125.
29. Pajukanta, P., Lilja, H. E., Sinsheimer, J. S., Cantor, R. M., Lusis, A. J., Gentile, M., Duan, X. J., Soro-Paavonen, A., Naukkarinen, J., Saarela, J., Laakso, M., Ehnholm, C., Taskinen, M. R. & Peltonen, L. (2004) Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet 36, 371-376.
30. Pajukanta, P., Nuotio, I., Terwilliger, J. D., Porkka, K. V., Ylitalo, K., Pihlajamaki, J., Suomalainen, A. J., Syvanen, A. C., Lehtimaki, T., Viikari, J. S., Laakso, M., Taskinen, M. R., Ehnholm, C. & Peltonen, L. (1998) Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nat Genet 18, 369-373.
31. Pajukanta, P., Terwilliger, J. D., Perola, M., Hiekkalinna, T., Nuotio, I., Ellonen, P., Parkkonen, M., Hartiala, J., Ylitalo, K., Pihlajamaki, J., Porkka, K., Laakso, M., Viikari, J., Ehnholm, C., Taskinen, M. R. & Peltonen, L. (1999) Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. Am J Hum Genet 64, 1453-1463.
32. Peacock, J. M., Arnett, D. K., Atwood, L. D., Myers, R. H., Coon, H., Rich, S. S., Province, M. A. & Heiss, G. (2001) Genome scan for quantitative trait loci linked to high-density lipoprotein cholesterol: The NHLBI Family Heart Study. Arterioscler Thromb Vasc Biol 21, 1823-1828.
33. Perusse, L., Rice, T., Despres, J. P., Bergeron, J., Province, M. A., Gagnon, J., Leon, A. S., Rao, D. C., Skinner, J. S., Wilmore, J. H. & Bouchard, C. (1997) Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study. Arterioscler Thromb Vasc Biol 17, 3263-3269.
34. Rainwater, D. L., Almasy, L., Blangero, J., Cole, S. A., Vandeberg, J. L., Maccluer, J. W. & Hixson, J. E. (1999) A genome search identifies major quantitative trait loci on human chromosomes 3 and 4 that influence cholesterol concentrations in small LDL particles. Arterioscler Thromb Vasc Biol 19, 777-783.
35. Rice, T., Vogler, G. P., Perry, T. S., Laskarzewski, P. M. & Rao, D. C. (1991) Familial aggregation of lipids and lipoproteins in families ascertained through random and nonrandom probands in the Iowa Lipid Research Clinics family study. Hum Hered 41, 107-121.
36. Scott, W. K., Hauser, E. R., Schmechel, D. E., Welsh-Bohmer, K. A., Small, G. W., Roses, A. D., Saunders, A. M., Gilbert, J. R., Vance, J. M., Haines, J. L. & Pericak-Vance, M. A. (2003) Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. Am J Hum Genet 73, 1041-1051.
37. Shearman, A. M., Ordovas, J. M., Cupples, L. A., Schaefer, E. J., Harmon, M. D., Shao, Y., Keen, J. D., Destefano, A. L., Joost, O., Wilson, P. W., Housman, D. E. & Myers, R. H. (2000) Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: A genome-wide scan in the Framingham study. Hum Mol Genet 9, 1315-1320.
38. Vance, J. M. & Ben Othmane, K. (1998) Methods of genotyping, New York, NY: Wiley-Liss.
39. Vega, G. L., Cater, N. B., Hadizadeh, D. R., 3 rd, Meguro, S. & Grundy, S. M. (2003) Free fatty acid metabolism during fenofibrate treatment of the metabolic syndrome. Clin Pharmacol Ther 74, 236-244.
40. Vionnet, N., Hani El, H., Dupont, S., Gallina, S., Francke, S., Dotte, S., De Matos, F., Durand, E., Lepretre, F., Lecoeur, C., Gallina, P., Zekiri, L., Dina, C. & Froguel, P. (2000) Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 67, 1470-1480.
41. Warnick, G. R., Benderson, J. & Albers, J. J. (1982) Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem 28, 1379-1388.
42. Yu, Y., Wyszynski, D. F., Waterworth, D. M., Wilton, S. D., Barter, P. J., Kesaniemi, Y. A., Mahley, R. W., McPherson, R., Waeber, G., Bersot, T. P., Ma, Q., Sharma, S. S., Montgomery, D. S., Middleton, L. T., Sundseth, S. S., Mooser, V., Grundy, S. M. & Farrer, L. A. (2005) Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia. J Lipid Res 46, 2202-2213.