A monotonous population of elongated cells (MPECS) in colorectal adenoma indicates a high risk of metachronous cancer

American Journal of Surgical Pathology

Volumn 30, Issue 9, 2006, Pages 1120-1129

  Soreide, Kjetil ^a   Buter, Tirza C E ^a   Janssen, Emiel A M ^a   Van Diermen, Bianca ^a   Baak, Jan P A ^a,b  

^a STAVANGER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

Biomarker; Colorectal adenoma; Colorectal cancer; Metachronous cancer; Prognosis

Indexed keywords

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; CANCER PATIENT; CANCER RISK; CARCINOGENESIS; CELL POPULATION; CELL STRUCTURE; CLINICAL FEATURE; COLONOSCOPY; COLORECTAL ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE MARKER; FEMALE; FOLLOW UP; GASTROINTESTINAL DYSPLASIA; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; INTESTINE POLYP; INTESTINE VILLUS; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PATHOLOGY; PROGNOSIS; QUANTITATIVE ANALYSIS; TRANSVERSE COLON; UNIVARIATE ANALYSIS;

ADENOMA; COLONIC POLYPS; COLORECTAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASMS, SECOND PRIMARY; PROGNOSIS;

EID: 33748065297     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000208904.53977.80     Document Type: Article

References (66)

1. Angell-Andersen E, Tretli S, Coleman MP, et al. Colorectal cancer survival trends in Norway 1958-1997. Eur J Cancer. 2004;40:734-742.
2. Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med. 1992;326:658-662.
3. Avery A, Paraskeva C, Hall P, et al. TGF-beta expression in the human colon: differential immunostaining along crypt epithelium. Br J Cancer. 1993;68:137-139.
4. Baak JP. The framework of pathology: good laboratory practice by quantitative and molecular methods. J Pathol. 2002;198:277-283.
5. Baak JP, Janssen EA, Soreide K, et al. Genomics and proteomics - the way forward. Ann Oncol. 2005;16:ii30-ii44.
6. Baak JP, Mutter GL, Robboy S, et al. The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer. 2005;103:2304-2312.
7. Baak JP, Noteboom E, Koevoets JJ. The influence of fixatives and other variations in tissue processing on nuclear morphometric features. Anal Quant Cytol Histol. 1989;11:219-224.
8. Bol MG, Baak JP, Rep S, et al. Prognostic value of proliferative activity and nuclear morphometry for progression in TaT1 urothelial cell carcinomas of the urinary bladder. Urology. 2002;60:1124-1130.
9. Breivik J, Gaudernack G. Resolving the evolutionary paradox of genetic instability: a cost-benefit analysis of DNA repair in changing environments. FEBS Lett. 2004;563:7-12.
10. Bretthauer M, Skovlund E, Grotmol T, et al. Inter-endoscopist variation in polyp and neoplasia pick-up rates in flexible sigmoidoscopy screening for colorectal cancer. Scand J Gastroenterol. 2003;38:1268-1274.
11. Burmer GC, Loeb LA. Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma. Proc Natl Acad Sci U S A. 1989;86:2403-2407.
12. de Silva WM. Developing a molecular marker for metachronous colorectal cancer. Ceylon Med J. 1999;44:162-165.
13. Deschner EE, Lipkin M. Proliferative patterns in colonic mucosa in familial polyposis. Cancer. 1975;35:413-418.
14. Doria-Rose VP, Levin TR, Selby JV, et al. The incidence of colorectal cancer following a negative screening sigmoidoscopy: implications for screening interval. Gastroenterology. 2004;127:714-722.
15. Eide TJ. A morphometrical analysis of dysplasia in small adenomas of the large intestine. Virchows Arch A Pathol Anat Histopathol. 1986;410:119-124.
16. Eide TJ. Risk of colorectal cancer in adenoma-bearing individuals within a defined population. Int J Cancer. 1986;38:173-176.
17. Eide TJ, Nielsen K, Solberg S. Dysplasia in colorectal adenomas related to the presence of O-acylated sialic mucin and to morphometric measurements. APMIS. 1987;95:365-369.
18. Fleege JC, Baak JP, Smeulders AW. Analysis of measuring system parameters that influence reproducibility of morphometric assessments with a graphic tablet. Hum Pathol. 1988;19:513-517.
19. Fleege JC, van Diest PJ, Baak JPA. Reliability of quantitative pathological assessments, standards, and quality control. In: Baak JPA, ed. Manual of Quantitative Pathology in Cancer Diagnosis and Prognosis. Berlin: Springer; 1991:151-181.
20. Fukutomi Y, Moriwaki H, Nagase S, et al. Metachronous colon tumors: risk factors and rationale for the surveillance colonoscopy after initial polypectomy. J Cancer Res Clin Oncol. 2002;128:569-574.
21. Gervaz P, Bucher P, Neyroud-Caspar I, et al. Proximal location of colon cancer is a risk factor for development of metachronous colorectal cancer: a population-based study. Dis Colon Rectum. 2005;48:227-232.
22. Hamilton SR, Vogelstein B, Kudo S, et al. Tumours of the colon and rectum. In: Hamilton S, Aaltonen LA, eds. World Health Organization Classification of Tumours. Pathology and Genetics-Tumours of the Digestive System. Lyon: IARC Press; 2000:103-144.
23. Hermsen M, Postma C, Baak J, et al. Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology. 2002;123:1109-1119.
24. Hsu CY, Kurman RJ, Vang R, et al. Nuclear size distinguishes low-from high-grade ovarian serous carcinoma and predicts outcome. Hum Pathol. 2005;36:1049-1054.
25. Ikeda Y, Mori M, Shibahara K, et al. The role of adenoma for colorectal cancer development: differences in the distribution of adenoma with low-grade dysplasia, high-grade dysplasia, and cancer that invades the submucosa. Surgery. 2002;131:S105-108.
26. Ikeguchi M, Sakatani T, Endo K, et al. Computerized nuclear morphometry is a useful technique for evaluating the high metastatic potential of colorectal adenocarcinoma. Cancer. 1999;86:1944-1951.
27. Jass JR, Whitehall VL, Young J, et al. Emerging concepts in colorectal neoplasia. Gastroenterology. 2002;123:862-876.
28. Korner H, Soreide K, Stokkeland PJ, et al. Systematic follow-up after curative surgery for colorectal cancer in Norway: a population-based audit of effectiveness, costs, and compliance. J Gastrointest Surg. 2005;9:320-328.
29. Kruse AJ, Skaland I, Janssen EA, et al. Quantitative molecular parameters to identify low-risk and high-risk early CIN lesions: role of markers of proliferative activity and differentiation and Rb availability. Int J Gynecol Pathol. 2004;23:100-109.
30. Lan YT, Lin JK, Li AF, et al. Metachronous colorectal cancer: necessity of post-operative colonoscopic surveillance. Int J Colorectal Dis. 2005;20:121-125.
31. Loeve F, van Ballegooijen M, Boer R, et al. Colorectal cancer risk in adenoma patients: a nation-wide study. Int J Cancer. 2004;111:147-151.
32. Lotfi AM, Spencer RJ, Ilstrup DM, et al. Colorectal polyps and the risk of subsequent carcinoma. Mayo Clin Proc. 1986;61:337-343.
33. Lund JN, Scholefield JH, Grainge MJ, et al. Risks, costs, and compliance limit colorectal adenoma surveillance: lessons from a randomised trial. Gut. 2001;49:91-96.
34. Lynch PM, Wargovich MJ, Lynch HT, et al. A follow-up study of colonic epithelial proliferation as a biomarker in a Native-American family with hereditary nonpolyposis colon cancer. J Natl Cancer Inst. 1991;83:951-954.
35. Maltzman T, Knoll K, Martinez ME, et al. Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: relationship to histologic and clinical characteristics. Gastroenterology. 2001;121:302-309.
36. McArdle CS, McKee RF, Finlay IG, et al. Improvement in survival following surgery for colorectal cancer. Br J Surg. 2005;92:1008-1013.
37. McGrath JS, Ponich TP, Gregor JC. Screening for colorectal cancer: the cost to find an advanced adenoma. Am J Gastroenterol. 2002;97:2902-2907.
38. Meijer GA, Baak JP, Talbot IC, et al. Predicting the risk of metachronous colorectal cancer in patients with rectosigmoid adenoma using quantitative pathological features. A case-control study. J Pathol. 1998;184:63-70.
39. Meijer GA, Fleege JC, Baak JP. Stereological assessment of architectural changes in dysplastic epithelium of colorectal adenomas. Pathol Res Pract. 1994;190:333-341.
40. Meijer GA, van Diest PJ, Fleege JC, et al. Syntactic structure analysis of the arrangement of nuclei in dysplastic epithelium of colorectal adenomatous polyps. Anal Quant Cytol Histol. 1992;14:491-498.
41. Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med. 2005;352:476-487.
42. Mills SJ, Mathers JC, Chapman PD, et al. Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis. Gut. 2001;48:41-46.
43. Morin PJ, Sparks AB, Korinek V, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997;275:1787-1790.
44. Neugut AI, Jacobson JS, Rella VA. Prevalence and incidence of colorectal adenomas and cancer in asymptomatic persons. Gastrointest Endosc Clin N Am. 1997;7:387-399.
45. O'Brien MJ, Winawer SJ, Zauber AG, et al., The National Polyp Study. Patient and polyp characteristics associated with high-grade dysplasia in colorectal adenomas. Gastroenterology. 1990;98:371-379.
46. Otchy DP, Ransohoff DF, Wolff BG, et al. Metachronous colon cancer in persons who have had a large adenomatous polyp. Am J Gastroenterol. 1996;91:448-454.
47. Park HS, Goodlad RA, Ahnen DJ, et al. Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently. Am J Pathol. 1997;151:843-852.
48. Pignone M. Screening for colorectal cancer: good, but not perfect. Gastroenterology. 2004;127:989-990.
49. Polkowski W, van Lanschot JJ, van Sandick JW, et al. The role of quantitative pathology in clinical decision making for Barrett's oesophagus. Anal Cell Pathol. 2003;25:123-127.
50. Radtke F, Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science. 2005;307:1904-1909.
51. Regueiro CR. AGA Future Trends Committee report: Colorectal cancer: a qualitative review of emerging screening and diagnostic technologies. Gastroenterology. 2005;129:1083-1103.
52. Rex DK. Colonoscopy: a review of its yield for cancers and adenomas by indication. Am J Gastroenterol. 1995;90:353-365.
53. Robertson DJ, Greenberg ER, Beach M, et al. Colorectal cancer in patients under close colonoscopic surveillance. Gastroenterology. 2005;129:34-41.
54. Rooney PS, Robinson MH, Clarke PA, et al. Individuals with a strong family history of colorectal cancer demonstrate abnormal rectal mucosal proliferation. Br J Surg. 1993;80:249-251.
55. Scheiden R, Sand J, Pandin M, et al. Colorectal high-grade adenomas: incidence, localization and adenoma-adenocarcinoma ratio in a retrospective and comparative population-based study of 225 consecutive cases between 1988 and 1996. Int J Colorectal Dis. 2000;15:29-34.
56. Shivapurkar N, Huang L, Ruggeri B, et al. K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients. Cancer Lett. 1997;115:39-46.
57. Soreide K, Janssen EA, Soiland H, et al. Microsatellite instability in colorectal cancer. Br J Surg. 2006;93:395-406.
58. Spencer RJ, Melton LJ, 3rd, Ready RL, et al. Treatment of small colorectal polyps: a population-based study of the risk of subsequent carcinoma. Mayo Clin Proc. 1984;59:305-310.
59. Takayama T, Katsuki S, Takahashi Y, et al. Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med. 1998;339:1277-1284.
60. Terpstra OT, van Blankenstein M, Dees J, et al. Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer. Gastroenterology. 1987;92:704-708.
61. Vamosi-Nagy I, Koves I. Correlation between colon adenoma and cancer. Eur J Surg Oncol. 1993;19:619-624.
62. van de Wetering M, Sancho E, Verweij C, et al. The beta-catenin/ TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 2002;111:241-250.
63. van Grieken NC, Meijer GA, Kale I, et al. Quantitative assessment of gastric antrum atrophy shows restitution to normal histology after Helicobacter pylori eradication. Digestion. 2004;69:27-33.
64. Volk EE, Goldblum JR, Petras RE, et al. Management and outcome of patients with invasive carcinoma arising in colorectal polyps. Gastroenterology. 1995;109:1801-1807.
65. Weitz J, Koch M, Debus J, et al. Colorectal cancer. Lancet. 2005;365:153-165.
66. Wong AJ, Kohn GJ, Schwartz HJ, et al. Colorectal cancer and noncancer patients have similar labeling indices by microscopy and computed image analysis. Hum Pathol. 1995;26:1329-1332.