The roles of Arkadia in renal tubular epithelial to mesenchymal transition

Medical Hypotheses

Volumn 67, Issue 5, 2006, Pages 1205-1207

  Liu, Fu You ^a   Li, Xiao Zhao ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE;

ARTICLE; ENZYME DEGRADATION; HUMAN; KIDNEY TUBULE EPITHELIUM; MESENCHYME CELL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

EMBRYONIC DEVELOPMENT; EPITHELIAL CELLS; FEMALE; HUMANS; KIDNEY TUBULES; MESODERM; NUCLEAR PROTEINS; PREGNANCY; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 33748044326     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.04.050     Document Type: Article

References (11)

1. Liu Y.H. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15 1 (2004) 1-12
2. Yang J.W., and Liu Y.H. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159 4 (2001) 1465-1475
3. 1 on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 13 6 (2002) 1464-1472
4. Moustakas A., Souchelnytskyi S., and Heldin C.H. Smad regulation in TGF-beta signal transduction. J Cell Sci 114 Pt 24 (2001) 4359-4369
5. Lan H.Y., Mu W., Tomita N., et al. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 14 6 (2003) 1535-1548
6. Fukasawa H., Yamamoto T., Togawa A., et al. Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci USA 101 23 (2004) 8687-8692
7. Lo R.S., and Massague J. Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat Cell Biol 1 8 (1999) 472-478
8. Kornitzer D., and Ciechanover A. Modes of regulation of ubiquitin-mediated protein degradation. J Cell Physiol 182 1 (2000) 1-11
9. Daizo K., Masahiko A., Akioshi K., et al. Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7. The EMBO J 22 24 (2003) 6458-6470
10. Schier Af. Nodal signaling in vertebrate development. Annu Rev Cell Dev Biol 19 (2003) 589-621
11. Hanyu A., Ishidou Y., Ebisawa T., et al. The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling. J Cell Biol 155 6 (2001) 1017-1027