Cognitive Functioning and Sex Steroid Hormone Gene Polymorphisms in Women at Midlife

American Journal of Medicine

Volumn 119, Issue 9 SUPPL. 1, 2006, Pages

  Kravitz, Howard M ^a   Meyer, Peter M ^a   Seeman, Teresa E ^b   Greendale, Gail A ^b   Sowers, MaryFran R ^c  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cognition; Digit Span Backward Test; East Boston Memory Test; Genetics; Sex steroid hormones; Symbol Digit Modalities Test

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DNA; ESTROGEN; ESTROGEN RECEPTOR; SEX HORMONE;

ADULT; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; CHINESE; COGNITION; CONTROLLED STUDY; DNA POLYMORPHISM; ESTROGEN METABOLISM; ESTROGEN SYNTHESIS; ETHNOLOGY; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MARKER GENE; PRIORITY JOURNAL; RACE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; WORKING MEMORY;

17-HYDROXYSTEROID DEHYDROGENASES; AROMATASE; COGNITION; CONTINENTAL POPULATION GROUPS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENOTYPE; GONADAL STEROID HORMONES; HEALTH SURVEYS; HUMANS; MEMORY DISORDERS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 33747894080     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2006.07.030     Document Type: Article

References (40)

1. Meyer P.M., Powell L.H., Wilson R.S., et al. A population-based longitudinal study of cognitive functioning in the menopausal transition. Neurology 61 (2003) 801-806
2. Everson-Rose S.A., Mendes de Leon C.F., Bienias J.L., Wilson R.S., and Evans D.A. Early life conditions and cognitive functioning in later life. Am J Epidemiol 58 (2003) 1083-1089
3. Brody N. Intellligence. 2nd ed. (1992), Academic Press, San Diego
4. Mackintosh N.J. IQ and Human Intelligence (1998), Oxford University Press, Oxford, England
5. Plomin R. Quantitative trait loci and general cognitive ability. In: Benjamin J., Ebstein R.P., and Belmaker R.H. (Eds). Molecular Genetics of Human Personality (2002), American Psychiatric Publishing, Inc, New York 211-230
6. Plomin R., and DeFries J.C. The genetics of cognitive abilities and disabilities. Sci Am 278 (1998) 62-69
7. Plomin R. The nature and nurture of cognitive abilities. In: Sternberg R.J. (Ed). Advances in the Psychology of Human Intelligence volume 4 (1988), Lawrence Erlbaum Associates, Inc, Hillsdale, NJ 1-33
8. Ostlund H., Keller E., and Hurd Y.L. Estrogen receptor gene expression in relation to neuropsychiatric disorders. Ann N Y Acad Sci 1007 (2003) 54-63
9. Stoffel-Wagner B. Neurosteroid biosynthesis in the human brain and its clinical implications. Ann N Y Acad Sci 1007 (2003) 64-78
10. Hogervorst E., Yaffe K., Richards M., and Huppert F. Hormone replacement therapy for cognitive function in postmenopausal women. Cochrane Database Syst Rev 3 (2002) CD003122
11. Nelson H.D., Humphrey L.L., Nygren P., Teutsch S.M., and Allan J.D. Postmenopausal hormone replacement therapy: scientific review. JAMA 288 (2002) 872-881
12. Shumaker S.A., Legault C., Rapp S.R., et al., WHIMS Investigators. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women. The Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 289 (2003) 2651-2662
13. Rapp S.R., Espeland M.A., Shumaker S.A., et al., WHIMS Investigators. Effect of estrogen plus progestin on global cognitive function in postmenopausal women. The Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 289 (2003) 2663-2672
14. Shumaker S.A., Legault C., Kuller L., et al., Women's Health Initiative Memory Study Investigators. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 291 (2004) 2947-2958
15. Espeland M.A., Rapp S.R., Shumaker S.A., et al., Women's Health Initiative Memory Study Investigators. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA 291 (2004) 2958-2968
16. Yaffe K., Lui L.-Y., Grady D., Stone K., and Morin P. Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women. Biol Psychiatry 51 (2002) 677-682
17. Sowers M.F., Crawford S.L., Sternfeld B., et al. SWAN: a multicenter, multiethnic, community-based cohort study of women and the menopausal transition. In: Lobo R., Marcus R., and Kelsey J. (Eds). Menopause: Biology and Pathobiology (2000), Academic Press, San Diego, CA 175-188
18. Albert M., Smith L.A., Scherr P.A., Taylor J.O., Evans D.A., and Funkenstein H.H. Use of brief cognitive tests to identify individuals in the community with clinically diagnosed Alzheimer's disease. Int J Neurosci 57 (1991) 167-178
19. Scherr P.A., Albert M.S., Funkenstein H.H., et al. Correlates of cognitive function in an elderly community population. Am J Epidemiol 128 (1988) 1084-1101
20. Wechsler D. Wechsler Memory Scale-Revised Manual (1987), The Psychological Corporation, New York
21. Smith A. Symbol Digit Modalities Test Manual-Revised (1982), Western Psychological Services, Los Angeles
22. R Development Core Team. R: A Language and Environment for Statistical Computing (2005), R Foundation for Statistical Computing, Vienna, Austria
23. Efron B., and Tibshirani R. Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy. Stat Sci 1 (1986) 54-77
24. Rothman K.J. No adjustments are needed for multiple comparisons. Epidemiology 1 (1990) 43-46
25. Budson A.E., and Price B.H. Memory dysfunction. N Engl J Med 352 (2005) 692-699
26. Squire L.R. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. [published correction appears in Psychol Rev. 1992;99:582]. Psychol Rev 99 (1992) 195-231
27. Osterlund M.K., Grandien K., Keller E., and Hurd Y.L. The human brain has distinct regional expression patterns of estrogen receptor alpha mRNA isoforms derived from alternative promoters. J Neurochem 75 (2000) 1390-1397
28. Henderson V.W. Hormone Therapy and the Brain: A Clinical Perspective on the Role of Estrogen (2000), Parthenon Publishing, New York
29. Brandi M.L., Becherini L., Gennari L., et al. Association of estrogen receptor α gene polymorphisms with sporadic Alzheimer's disease. Biochem Biophys Res Commun 265 (1999) 335-338
30. Isoe-Wada K., Maeda M., Yong J., et al. Positive association between an estrogen receptor gene polymorphism and Parkinson's disease with dementia. Eur J Neurol 6 (1999) 431-435
31. Mattila K.M., Axelman K., Rinne J.O., et al. Interaction between estrogen receptor 1 and the ε4 allele of apolipoprotein E increases the risk of familial Alzheimer's disease in women. Neurosci Lett 282 (2000) 45-48
32. Maruyama H., Toji H., Harrington C.R., et al. Lack of an association of estrogen receptor α gene polymorphisms and transcriptional activity with Alzheimer disease. Arch Neurol 57 (2000) 236-240
33. Stoffel-Wagner B., Watzka M., Steckelbroeck S., Schramm J., Bidlingmaier J.F., and Klingmuller D. Expression of 17β-hydroxysteroid dehydrogenase types 1, 2, 3 and 4 in the human temporal lobe. J Endocrinol 160 (1999) 119-126
34. Steckelbroeck S., Watzka M., Stoffel-Wagner B., et al. Expression of the 17β-hydroxysteroid dehydrogenase type 5 mRNA in the human brain. Mol Cell Endocrinol 171 (2001) 165-168
35. Kemper T. Neuroanatomical and neuropathological changes during aging and dementia. In: Albert M., and Knoefel J. (Eds). Clinical Neurology of Aging. 2nd ed. (1994), Oxford University Press, New York 3-67
36. Bartzokis G., Beckson M., Lu P.H., Neuchterlein K.H., Edwards N., and Mintz J. Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study. Arch Gen Psychiatry 58 (2001) 461-465
37. Bartzokis G. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease. Neurobiol Aging 25 (2004) 5-18
38. Bartzokis G. Quadratic trajectories of brain myelin content: unifying construct for neuropsychiatric disorders. Neurobiol Aging 25 (2004) 49-62
39. Stoffel-Wagner B., Watzka M., Schramm J., Bidlingmaier F., and Klingmuller D. Expression of CYP19 (aromatase) mRNA in different areas of the human brain. J Steroid Biochem Mol Biol 70 (1999) 237-241
40. Wozniak A., Hutchison R.E., Morris C.M., and Hutchison J.B. Neuroblastoma and Alzheimer's disease brain cells contain aromatase activity. Steroids 63 (1998) 263-267