Antithrombin reduces reperfusion-induced liver injury by enhancing sensory neuron activation

Thrombosis and Haemostasis

Volumn 95, Issue 5, 2006, Pages 788-795

  Harada, Naoaki ^a   Okajima, Kenji ^b   Uchiba, Mitsuhiro ^a   Kurihara, Hiroki ^c   Nakagata, Naomi ^d  

^a KUMAMOTO UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Antithrombin; Calcitonin gene related peptide; Capsaicin sensitive sensory neurons; Liver injury; Protein kinase A

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ALANINE AMINOTRANSFERASE; ALPHA CALCITONIN GENE RELATED PEPTIDE; ANANDAMIDE; ANTITHROMBIN; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; KT 5720; MYELOPEROXIDASE; PROSTACYCLIN; TUMOR NECROSIS FACTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; FEMALE; IN VIVO STUDY; INTRACELLULAR SPACE; LIVER BLOOD FLOW; LIVER INJURY; LIVER ISCHEMIA; MALE; METABOLITE; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REPERFUSION INJURY; SENSORY NERVE CELL; SPINAL GANGLION; WILD TYPE;

AMORPHOUS MATERIALS; CRITICAL CURRENTS; HEAT TREATMENT; MAGNETIZATION; OXIDATION; PROTECTIVE ATMOSPHERES; SUPERCONDUCTIVITY;

MG FLAKE; PIT TAPE; POWDER-IN-TUBE;

MAGNESIUM COMPOUNDS;

EID: 33747884346     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physc.2006.06.015     Document Type: Article

References (39)

1. Rosenberg RD. Biochemistry of heparin antithrombin interactions, and the physiological role of this natural anticoagulant mechanism. Am J Med 1989; 87 (Suppl 3B): 2S-9S.
2. Okajima K, Ueyama H, Hashimoto Y, et al. Homozygous variant of antithrombin III that lacks affinity for heparin: AT III Kumamoto. Thromb Haemost 1989; 61: 20-4.
3. Okajima K, Abe H, Maeda S, et al. Antithrombin III Nagasaki (Ser116-Pro): a heterozygous variant with defective heparin binding associated with thrombosis. Blood 1993; 81: 1300-5.
4. Coccheri S, Palareti G. Antithrombin III replacement in orthotopic liver transplantation. Semin Thromb Haemost 1993; 19: 268-72.
5. Okajima K. Regulation of inflammatory responses by natural anticoagulants. Immunol Rev 2001; 184: 258-74.
6. Keller GA, West MA, Cerra FB, et al. Macrophage-mediated modulation of hepatic function in multi-system failure. J Surg Res 1985; 39: 555-63.
7. Jaeschke H, Farhood A, Smith CW. Neutrophils contribute to ischemia/ reperfusion injury in rat liver in vivo. FASEB J 1990; 4: 3355-9.
8. Eisenhut T, Sinha B, Grottrup-Wolfers E, et al. Prostacyclin analogs suppress the synthesis of tumor necrosis factor-α in LPS-stimulated human peripheral blood mononuclear cells. Immunopharmacology 1993; 26: 259-64.
9. Kainoh M, Imai R, Umetsu T, et al. Prostacyclin and beraprost sodium as suppressors of activated rat polymorphonuclear leukocytes. Biochem Pharmacol 1990; 39: 477-84.
10. Dray A. Inflammatory mediators of pain. Br J Anaesth 1995; 75: 125-31.
11. Szallasi A, Blumberg PM. Vanilloid receptors: new insights enhance potential as a therapeutic target. Pain 1996; 68: 195-208.
12. Crossman D, McEwan J, MacDermot J, et al. Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells. Br J Pharmacol 1987; 92: 695-701.
13. Fields HL. Pain. New York: McGraw-Hill, 1987.
14. Harada N, Okajima K, Uchiba M, et al. Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats. J Lab Clin Med 2002; 139: 218-26.
15. Harada N, Okajima K, Yuksel M, et al. Contribution of capsaicin-sensitive sensory neurons to antithrombin-induced reduction of ischemia/reperfusion-induced liver injury in rats. Thromb Haemost 2005; 93: 48-56.
16. Uchiba M, Okajima K, Kaun C, et al. Inhibition of the endothelial cell activation by antithrombin in vitro. Thromb Haemost 2004; 92: 1420-7.
17. De Petrocellis L, Harrison S, Bisogno T, et al. The vanilloid receptor (VR-1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase. J Neurochem 2001; 77: 1660-3.
18. Oh-hashi Y, Shindo T, Kurihara Y, et al. Elevated sympathetic nervous activity in mice deficient in aCGRP. Circ Res 2001; 89: 983-90.
19. Miller-Anderson M, Borg H, Anderson LO. Purification of antithrombin III by affinity chromatography. Thromb Res 1974; 5: 439-52.
20. 1α in rats. Thromb Res 1995; 80: 201-8.
21. Khandoga A, Biberthaler P, Messmer K, et al. Platelet-endothelial cell interactions during hepatic ischemia-reperfusion in vivo: a systematic analysis. Microvasc Res 2003; 65: 71-7.
22. Hayashi H, Chaudry IH, Clemens MG, et al. Hepatic ischemia models for determining the effects of ATP-MgCl2 treatment. J Surg Res 1986; 40: 167-75.
23. Liu L, Simon SA. Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. Neurosci Lett 1997; 228: 29-32.
24. Akiyoshi H, Gonda T, Terada T. A comparative histochemical and immunohistochemical study of aminergic, cholinergic and peptidergic innervation in rat, hamster, guinea pig, dog and human livers. Liver 1998; 18: 352-9.
25. Harada N, Okajima K, Kushimoto S, et al. Antithrombin reduces ischemia/ reperfusion injury of rat liver by increasing the hepatic level of prostacyclin. Blood 1999; 93: 157-64.
26. Shito M, Wakabayashi G, Ueda M, et al. Interleukin 1 receptor blockade reduces tumor necrosis factor production, tissue injury, and mortality after hepatic ischemia-reperfusion in the rat. Transplantation 1997; 63: 143-8.
27. Warren JS, Yabroff KR, Remick DG, et al. Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat. J Clin Invest 1989; 84: 1873-82.
28. Kushimoto S, Okajima K, Uchiba M, et al. Role of granulocyte elastase in ischemia/reperfusion injury of rat liver. Crit Care Med 1996; 24: 1908-12.
29. Tognetto M, Amadesi S, Harrison S, et al. Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation. J Neurosci 2001; 21: 1104-9.
30. Price TJ, Patwardhan A, Akopian AN, et al. Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyldopamine and arachidonyl-2-chloroethylamide. Br J Pharmacol 2004; 141: 1118-30.
31. 2+]i elevation in DRG neurons of neonatal rats. J Neurosci Res 2001; 66: 592-600.
32. Bull HA, Hothersall J, Chowdhury N, et al. Neuropeptides induce release of nitric oxide from human dermal microvascular endothelial cells. J Invest Dermatol 1996; 106: 655-60.
33. 2) in chloralose anesthetized dogs. Br J Pharmacol 1977; 61: 136-41.
34. Harada N, Okajima K, Kushimoto S. Gabexate mesilate, a synthetic protease inhibitor, reduces ischemia/reperfusion injury of rat liver by inhibiting leukocyte activation. Crit Care Med 1999; 27: 1958-64.
35. Stoyanova II, Gulubova MV. Peptidergic nerve fibers in the human liver. Acta Histochem 1998; 100: 245-56.
36. Koj A, Regoeczi E. Effect of experimental inflammation on the synthesis and distribution of antithrombin III and alpha-1-antitrypsin in rabbits. Br J Exp Pathol 1978; 59: 473-81.
37. van Nieuw Amerongen GP, van Hinsbergh VW. Targets for pharmacological intervention of endothelial hyperpermeability and barrier function. Vascular Phamacol 2003; 39: 257-72.
38. Okajima K, Harada N, Uchiba M, et al. Neutrophil elasatase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats. Am J Physiol Gastrointest Liver Physiol 2004; 287: G1116-G1123.
39. Harada N, Okajima K, Uchiba M, et al. Antithrombin reduces ischemia/ reperfusion-induced liver injury in rats by activation of cyclooxygenase-1. Thromb Haemost 2004; 92: 550-8.