γ-Syntrophin scaffolding is spatially and functionally distinct from that of the α/β syntrophins

Experimental Cell Research

Volumn 312, Issue 16, 2006, Pages 3084-3095

  Alessi, Amy ^a   Bragg, April D ^a   Percival, Justin M ^a   Yoo, Jean ^a   Albrecht, Douglas E ^a   Froehner, Stanley C ^a   Adams, Marvin E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Dystrobrevin; Dystrophin; Neuronal nitric oxide synthase; Sarcoplasmic reticulum; Syntrophin; Utrophin

Indexed keywords

ALPHA SYNTROPHIN; BETA SYNTROPHIN; DYSTROPHIN; GAMMA SYNTROPHIN; SYNTROPHIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN; BRAIN NERVE CELL; CONTROLLED STUDY; HIPPOCAMPUS; MEMBRANE CHANNEL; MOUSE; NEUROMUSCULAR SYNAPSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PURKINJE CELL; PYRAMIDAL NERVE CELL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TISSUE DISTRIBUTION;

EID: 33747877879     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.06.019     Document Type: Article

References (43)

1. Albrecht D.E., and Froehner S.C. Syntrophins and dystrobrevins: defining the dystrophin scaffold at synapses. Neurosignals 11 (2002) 123-129
2. Percival J.M., Adams M.E., and Froehner S.C. Syntrophin: A Molecular Adaptor Conferring a Signaling Role to the Dystrophin-Associated Protein Complex (2004), Landers Bioscience, Georgetown, TX
3. Adams M.E., Dwyer T.M., Dowler L.L., White R.A., and Froehner S.C. Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome localization, and homology with a discs large domain. J. Biol. Chem. 270 (1995) 25859-25865
4. Ahn A.H., Yoshida M., Anderson M.S., Feener C.A., Selig S., Hagiwara Y., Ozawa E., and Kunkel L.M. Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 4446-4450
5. Ahn A.H., and Kunkel L.M. Syntrophin binds to an alternatively spliced exon of dystrophin. J. Cell Biol. 128 (1995) 363-371
6. Suzuki A., Yoshida M., and Ozawa E. Mammalian alpha 1- and beta 1-syntrophin bind to the alternative splice-prone region of the dystrophin COOH terminus. J. Cell Biol. 128 (1995) 373-381
7. Kachinsky A.M., Froehner S.C., and Milgram S.L. A PDZ-containing scaffold related to the dystrophin complex at the basolateral membrane of epithelial cells. J. Cell Biol. 145 (1999) 391-402
8. Adams M.E., Butler M.H., Dwyer T.M., Peters M.F., Murnane A.A., and Froehner S.C. Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Neuron 11 (1993) 531-540
9. Kramarcy N.R., and Sealock R. Syntrophin isoforms at the neuromuscular junction: developmental time course and differential localization. Mol. Cell. Neurosci. 15 (2000) 262-274
10. Adams M.E., Kramarcy N., Krall S.P., Rossi S.G., Rotundo R.L., Sealock R., and Froehner S.C. Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J. Cell Biol. 150 (2000) 1385-1398
11. Peters M.F., Adams M.E., and Froehner S.C. Differential association of syntrophin pairs with the dystrophin complex. J. Cell Biol. 138 (1997) 81-93
12. Peters M.F., Kramarcy N.R., Sealock R., and Froehner S.C. b2-Syntrophin: localization at the neuromuscular junction in skeletal muscle. NeuroReport 5 (1994) 1577-1580
13. Lumeng C., Phelps S., Crawford G.E., Walden P.D., Barald K., and Chamberlain J.S. Interactions between beta2-syntrophin and a family of microtubule-associated serine/threonine kinases. Nat. Neurosci. 2 (1999) 611-617
14. Hasegawa M., Cuenda A., Spillantini M.G., Thomas G.M., Buee-Scherrer V., Cohen P., and Goedert M. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. J. Biol. Chem. 274 (1999) 12626-12631
15. Hogan A., Shepherd L., Chabot J., Quenneville S., Prescott S.M., Topham M.K., and Gee S.H. Interaction of {gamma}1-syntrophin with diacylglycerol kinase-{zeta}: regulation of nuclear localization by PDZ interactions. J. Biol. Chem. 14 (2001) 14
16. Ort T., Maksimova E., Dirkx R., Kachinsky A.M., Berghs S., Froehner S.C., and Solimena M. The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. Eur. J. Cell Biol. 79 (2000) 621-630
17. Gee S.H., Madhavan R., Levinson S.R., Caldwell J.H., Sealock R., and Froehner S.C. Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. J. Neurosci. 18 (1998) 128-137
18. Schultz J., Hoffmuller U., Krause G., Ashurst J., Macias M.J., Schmieder P., Schneider-Mergener J., and Oschkinat H. Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels. Nat. Struct. Biol. 5 (1998) 19-24
19. Leonoudakis D., Conti L.R., Anderson S., Radeke C.M., McGuire L.M., Adams M.E., Froehner S.C., Yates III J.R., and Vandenberg C.A. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. J. Biol. Chem. 279 (2004) 22331-22346
20. Connors N.C., Adams M.E., Froehner S.C., and Kofuji P. The potassium channel Kir4.1 associates with the dystrophin glycoprotein complex via alpha-syntrophin in glia. J. Biol. Chem. 279 (2004) 28387-28392
21. Neely J.D., Amiry-Moghaddam M., Ottersen O.P., Froehner S.C., Agre P., and Adams M.E. Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 14108-14113
22. Brenman J.E., Chao D.S., Gee S.H., McGee A.W., Craven S.E., Santillano D.R., Wu Z., Huang F., Xia H., Peters M.F., Froehner S.C., and Bredt D.S. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 84 (1996) 757-767
23. Froehner S.C., Murnane A.A., Tobler M., Peng H.B., and Sealock R. A postsynaptic Mr 58,000 (58K) protein concentrated at acetylcholine receptor-rich sites in Torpedo electroplaques and skeletal muscle. J. Cell Biol. 104 (1987) 1633-1646
24. Adams M.E., Mueller H.A., and Froehner S.C. In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4. J. Cell Biol. 155 (2001) 113-122
25. Newey S.E., Benson M.A., Ponting C.P., Davies K.E., and Blake D.J. Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. Curr. Biol. 10 (2000) 1295-1298
26. Kramarcy N.R., Vidal A., Froehner S.C., and Sealock R. Association of utrophin and multiple dystrophin short forms with the mammalian Mr 58,000 dystrophin-associated protein (syntrophin). J. Biol. Chem. 269 (1994) 2870-2876
27. Musacchio A., Gibson T., Rice P., Thompson J., and Saraste M. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem. Sci. 18 (1993) 343-348
28. Saraste M., Sibbald P.R., and Wittinghofer A. The P-loop-a common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci. 15 (1990) 430-434
29. Bragg A.D., Amiry-Moghaddam M., Ottersen O.P., Adams M.E., and Froehner S.C. Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on alpha-syntrophin. Glia (2006)
30. Piluso G., Mirabella M., Ricci E., Belsito A., Abbondanza C., Servidei S., Puca A.A., Tonali P., Puca G.A., and Nigro V. Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. J. Biol. Chem. 275 (2000) 15851-15860
31. Hillier B.J., Christopherson K.S., Prehoda K.E., Bredt D.S., and Lim W.A. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science 284 (1999) 812-815
32. Thomas G.D., Shaul P.W., Yuhanna I.S., Froehner S.C., and Adams M.E. Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal Nitric oxide synthase. Circ. Res. 92 (2003) 554-560
33. r 87,000 postsynaptic protein. J. Biol. Chem. 267 (1992) 6213-6218
34. Yang B., Jung D., Rafael J.A., Chamberlain J.S., and Campbell K.P. Identification of alpha-syntrophin binding to syntrophin triplet, dystrophin, and utrophin. J. Biol. Chem. 270 (1995) 4975-4978
35. Jones K.J., Compton A.G., Yang N., Mills M.A., Peters M.F., Mowat D., Kunkel L.M., Froehner S.C., and North K.N. Deficiency of the syntrophins and alpha-dystrobrevin in patients with inherited myopathy. Neuromuscul. Disord. 13 (2003) 456-467
36. Marchand S., Stetzkowski-Marden F., and Cartaud J. Differential targeting of components of the dystrophin complex to the postsynaptic membrane. Eur. J. Neurosci. 13 (2001) 221-229
37. 2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. EMBO J. 20 (2001) 4013-4023
38. Mignery G.A., Sudhof T.C., Takei K., and De Camilli P. Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor. Nature 342 (1989) 192-195
39. Otsu H., Yamamoto A., Maeda N., Mikoshiba K., and Tashiro Y. Immunogold localization of inositol 1, 4, 5-trisphosphate (InsP3) receptor in mouse cerebellar Purkinje cells using three monoclonal antibodies. Cell Struct. Funct. 15 (1990) 163-173
40. Satoh T., Ross C.A., Villa A., Supattapone S., Pozzan T., Snyder S.H., and Meldolesi J. The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. J. Cell Biol. 111 (1990) 615-624
41. Berridge M.J. Neuronal calcium signaling. Neuron 21 (1998) 13-26
42. Yan J., Wen W., Xu W., Long J.F., Adams M.E., Froehner S.C., and Zhang M. Structure of the split PH domain and distinct lipid-binding properties of the PH-PDZ supramodule of alpha-syntrophin. EMBO J. 24 (2005) 3985-3995
43. Nagaya H., Wada I., Jia Y.J., and Kanoh H. Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains. Mol. Biol. Cell 13 (2002) 302-316