Aromatase Gene (CYP 19) Polymorphisms and Endogenous Androgen Concentrations in a Multiracial/Multiethnic, Multisite Study of Women at Midlife

American Journal of Medicine

Volumn 119, Issue 9 SUPPL. 1, 2006, Pages

  Sowers, MaryFran R ^a   Wilson, Angela L ^a   Kardia, Sharon R ^a   Chu, Jian ^a   Ferrell, Robert ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Androgens; Genetics; Sex hormones; Women

Indexed keywords

ANDROGEN; AROMATASE; BIOLOGICAL MARKER; CYTOCHROME P450; ESTRADIOL; ESTROGEN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AFRICAN AMERICAN; ANDROGEN BLOOD LEVEL; ARTICLE; BODY MASS; CAUCASIAN; CHINESE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME MECHANISM; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENOTYPE; GROUPS BY AGE; HEALTH STATUS; HORMONE DETERMINATION; HUMAN; JAPAN; MEDICAL ASSESSMENT; PRIORITY JOURNAL; RACE DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ANDROGENS; AROMATASE; CONTINENTAL POPULATION GROUPS; ESTRADIOL; FEMALE; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 33747884326     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2006.07.003     Document Type: Article

References (26)

1. Griffin J.E., and Wilson J.D. Disorders of the testes and the male reproductive tract. In: Williams R.H., Larsen P.R., Kronenberg H.M., Melmed S., and Polonsky K.S. (Eds). Williams Textbook of Endocrinology. 10th ed. (2003), WB Saunders, Philadelphia 715
2. Dhatariya K.K., and Nair K. Dehydroepiandrosterone: is there a role for replacement?. Mayo Clin Proc 78 (2003) 1257-1273
3. Bulun S.E., Sebastian S., Takayama K., Suzuki T., Sasano H., and Shozu M. The human CYP 19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters. J Steroid Biochem Mol Biol 86 (2003) 219-224
4. Meinhardt U., and Mullis P.E. The essential role of the aromatase/p450arom. Semin Reprod Med 20 (2002) 277-283
5. Bulun S.E., Takayama K., Suzuki T., Sasano H., Yilmaz B., and Sebastian S. Organization of the human aromatase P450 (CYP19) gene. Semin Reprod Med 22 (2004) 5-9
6. Fisher C.R., Graves K.H., Parlow A.F., and Simpson E.R. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the CYP19 gene. Proc Natl Acad Sci U S A 95 (1998) 6965-6970
7. Britt K.L., Drummond A.E., Dyson M., et al. The ovarian phenotype of the aromatase knockout (ArKO) mouse. J Steroid Biochem Mol Biol 79 (2001) 181-185
8. Ito Y., Fisher C.R., Conte F.A., Grumbach M.M., and Simpson E.R. Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Proc Natl Acad Sci U S A 90 (1993) 11673-11677
9. Morishima A., Grumbach M.M., Simpson E.R., Fisher C., and Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80 (1995) 3689-3698
10. arom gene: impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries and bone densitometry in childhood. J Clin Endocrinol Metab 82 (1997) 1739-1745
11. Belgorosky A., Pepe C., Marino R., et al. Hypothalamic-pituitary-ovarian axis during infancy, early and late prepuberty in an aromatase-deficient girl who is a compound heterozygote for two new point mutations of the CYP19 gene. J Clin Endocrinol Metab 88 (2003) 5127-5131
12. Berstein L.M., Imyanitov E.N., Suspitsin E.N., et al. CYP19 gene polymorphism in endometrial cancer patients. J Cancer Res Clin Oncol 127 (2001) 135-138
13. Dunning A.M., Dowsett M., Healey C.S., et al. Polymorphisms associated with circulating sex hormone in postmenopausal women. J Natl Cancer Inst 96 (2004) 936-945
14. Tworoger S.S., Chubak J., Aiello E.J., et al. Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women. Cancer Epidemiol Biomarkers Prev 13 (2004) 94-101
15. Single Nucleotide Polymorphism database: dbSNP search page. National Center for Biotechnology Information Web site. Available at: http://www.ncbi.nlm.nih.gov/SNP/. Accessed September 23, 2005.
16. Sowers M.F., Crawford S., Sternfeld B., et al. Design, survey sampling and recruitment methods of SWAN: a multicenter, multiethnic, community-based cohort study of women and the menopausal transition. In: Lobo R.A., Kelsey J., and Marcus R. (Eds). Menopause: Biology and Pathobiology (2000), Academic Press, San Diego, CA 175-188
17. Kardia S.R., Chu J., Sowers M.F., et al. Characterizing variation in sex steroid hormone pathway genes in women of 4 races/ethnicities: the Study of Women's Health Across the Nation (SWAN). Am J Med 119 suppl 9A (2006) S3-S15
18. Haiman C.A., Stram D.O., Pike M.C., et al. A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort. Hum Mol Genet 12 (2003) 2679-2692
19. Ferris B.G. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis 188 (1978) 1-120
20. Beer D.G., Kardia S.L.R., Huang C.-C., et al. Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med 8 (2002) 816-824
21. Buster J.E., and Casson P.R. DHEA: biology and use in therapeutic intervention. In: Lobo R.A., Kelsey J., and Marcus R. (Eds). Menopause: Biology and Pathobiology (2000), Academic Press, San Diego, CA 625-638
22. Simpson E., Rubin G., Clyne C., et al. The role of local estrogen biosynthesis in males and females. Trends Endocrinol Metab 11 (2000) 184-188
23. Labrie F., Bélanger A., Cusan L., Gomez J.L., and Candas B. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 82 (1997) 2396-2402
24. Haiman C.A., Hankinson S.E., Spiegelman D., et al. A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk. Int J Cancer 87 (2000) 204-210
25. Davison S.L., and Davis S.R. Androgens in women. J Steroid Biochem Mol Biol 85 (2003) 363-366
26. Key T., Appleby P., Barnes I., Reeves G., and Endogenous Hormones and Breast Cancer Collaborative Group. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 94 (2002) 606-616