Tracking the in vivo fate of recombinant polypeptides by isotopic labeling

Journal of Controlled Release

Volumn 114, Issue 2, 2006, Pages 184-192

  Liu, Wenge ^a   Dreher, Matthew R ^a   Chow, Dominic C ^a   Zalutsky, Michael R ^b   Chilkoti, Ashutosh ^a  

^a Duke University   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carbon 13 and carbon 14; E. coli; Elastin like polypeptide; Isotope labeling; Lower critical solution temperature; Pharmacokinetics; Radiolabeling

Indexed keywords

BIOTECHNOLOGY; CARBON; CELL CULTURE; ESCHERICHIA COLI; GLUCOSE; ISOTOPES; PHARMACOKINETICS;

CARBON-13 AND CARBON-14; ELASTIN-LIKE POLYPEPTIDE (ELP); ISOTOPE LABELING; LOWER CRITICAL SOLUTION TEMPERATURE; RADIOLABELING;

POLYPEPTIDES;

CARBON; CARBON 13; CARBON 14; ELASTIN; GLUCOSE; ISOPROPYL BETA THIOGALACTOSIDE; PHOSPHATE BUFFERED SALINE; POLYPEPTIDE; PYRANOSIDE; RECOMBINANT PROTEIN; TRACE ELEMENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BACTERIAL GROWTH; BACTERIUM CULTURE; BIOTECHNOLOGY; CELL DENSITY; CONTROLLED STUDY; CULTURE MEDIUM; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG STABILITY; ESCHERICHIA COLI; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; QUANTITATIVE ASSAY; SERUM; STOICHIOMETRY; TEMPERATURE DEPENDENCE; TISSUE ENGINEERING;

AUTORADIOGRAPHY; CARBON ISOTOPES; CULTURE MEDIA; DRUG STABILITY; ELASTIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; ISOTOPE LABELING; PEPTIDES; RECOMBINANT PROTEINS; TEMPERATURE; TISSUE DISTRIBUTION; TISSUE ENGINEERING;

EID: 33747875376     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.06.001     Document Type: Article

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