메뉴 건너뛰기




Volumn 44, Issue 4, 2007, Pages 377-388

Low doses of antigen coupled to anti-CR2 mAbs induce rapid and enduring IgG immune responses in mice and in cynomolgus monkeys

Author keywords

Anthrax protective antigen; Antigen presentation; B lymphocytes; Complement; Vaccination

Indexed keywords

7G6 MONOCLONAL ANTIBODY; ANTHRAX PROTECTIVE ANTIGEN; ANTHRAX TOXIN; ANTIBODY; ANTIGEN; COMPLEMENT RECEPTOR 2 MONOCLONAL ANTIBODY; HAPTEN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PROTEIN; UNCLASSIFIED DRUG;

EID: 33747868712     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.02.032     Document Type: Article
Times cited : (20)

References (58)
  • 1
    • 21544474979 scopus 로고    scopus 로고
    • Oral spore vaccine based on live attenuated nontoxinogenic Bacillus anthracis expressing recombinant mutant protective antigen
    • Aloni-Grinstein R., Gat O., Altboum Z., Velan B., Cohen S., and Shafferman A. Oral spore vaccine based on live attenuated nontoxinogenic Bacillus anthracis expressing recombinant mutant protective antigen. Infect. Immun. 73 (2005) 4043-4053
    • (2005) Infect. Immun. , vol.73 , pp. 4043-4053
    • Aloni-Grinstein, R.1    Gat, O.2    Altboum, Z.3    Velan, B.4    Cohen, S.5    Shafferman, A.6
  • 2
    • 0034283681 scopus 로고    scopus 로고
    • Antibody production in mice deficient for complement receptors 1 and 2 can be induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes
    • Applequist S.E., Dahlstrom J., Jiang N., Molina H., and Heyman B. Antibody production in mice deficient for complement receptors 1 and 2 can be induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes. J. Immunol. 165 (2000) 2398-2403
    • (2000) J. Immunol. , vol.165 , pp. 2398-2403
    • Applequist, S.E.1    Dahlstrom, J.2    Jiang, N.3    Molina, H.4    Heyman, B.5
  • 3
    • 19744368945 scopus 로고    scopus 로고
    • Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines
    • Aulinger B.A., Roehrl M.H., Mekalanos J.J., Collier R.J., and Wang J.Y. Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect. Immunity 73 (2005) 3408-3414
    • (2005) Infect. Immunity , vol.73 , pp. 3408-3414
    • Aulinger, B.A.1    Roehrl, M.H.2    Mekalanos, J.J.3    Collier, R.J.4    Wang, J.Y.5
  • 4
    • 0033559145 scopus 로고    scopus 로고
    • Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors
    • Baiu D.C., Preschl J., Tchorbanov A., Molina H.D., Erdei A., Sulica A., Capel P.J.A., and Hazenbos W.L.W. Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors. J. Immunol. 162 (1999) 3125-3130
    • (1999) J. Immunol. , vol.162 , pp. 3125-3130
    • Baiu, D.C.1    Preschl, J.2    Tchorbanov, A.3    Molina, H.D.4    Erdei, A.5    Sulica, A.6    Capel, P.J.A.7    Hazenbos, W.L.W.8
  • 5
    • 0018882953 scopus 로고
    • The use of avidin-biotin complex as a tool in molecular biology
    • Bayer E.A., and Wilchek M. The use of avidin-biotin complex as a tool in molecular biology. Methods Biochem. Anal. 26 (1980) 1-45
    • (1980) Methods Biochem. Anal. , vol.26 , pp. 1-45
    • Bayer, E.A.1    Wilchek, M.2
  • 6
    • 0037514199 scopus 로고    scopus 로고
    • Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen
    • Boyaka P.N., Tafaro A., Fischer R., Leppla S.H., Fujihashi K., and McGhee J.R. Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen. J. Immunol. 170 (2003) 5636-5643
    • (2003) J. Immunol. , vol.170 , pp. 5636-5643
    • Boyaka, P.N.1    Tafaro, A.2    Fischer, R.3    Leppla, S.H.4    Fujihashi, K.5    McGhee, J.R.6
  • 7
    • 0014960964 scopus 로고
    • Lymphocyte-mediated transport of aggregated human γ-globulin into germinal centre areas of normal mouse spleen
    • Brown J.C., De Jesus D.G., and Holborow E.J. Lymphocyte-mediated transport of aggregated human γ-globulin into germinal centre areas of normal mouse spleen. Nature 228 (1970) 367-369
    • (1970) Nature , vol.228 , pp. 367-369
    • Brown, J.C.1    De Jesus, D.G.2    Holborow, E.J.3
  • 8
    • 0015852050 scopus 로고
    • The localization of aggregated human γ-globulin in the spleens of normal mice
    • Brown J.C., Harris G., Papamichail M., Sljivic V.S., and Holborow E.J. The localization of aggregated human γ-globulin in the spleens of normal mice. Immunology 24 (1973) 955-968
    • (1973) Immunology , vol.24 , pp. 955-968
    • Brown, J.C.1    Harris, G.2    Papamichail, M.3    Sljivic, V.S.4    Holborow, E.J.5
  • 9
    • 0033990632 scopus 로고    scopus 로고
    • The role of complement in B cell activation and tolerance
    • Carroll M.C. The role of complement in B cell activation and tolerance. Adv. Immunol. 74 (2000) 61-88
    • (2000) Adv. Immunol. , vol.74 , pp. 61-88
    • Carroll, M.C.1
  • 10
    • 5444259851 scopus 로고    scopus 로고
    • The complement system in regulation of adaptive immunity
    • Carroll M.C. The complement system in regulation of adaptive immunity. Nat. Immunol. 5 (2004) 981-985
    • (2004) Nat. Immunol. , vol.5 , pp. 981-985
    • Carroll, M.C.1
  • 13
    • 0029916530 scopus 로고    scopus 로고
    • Antibody response to a T-dependent antigen requires B cell expression of complement receptors
    • Croix D.A., Ahearn J.M., Rosengard A.M., Han S., Kelsoe G., Ma M., and Carroll M.C. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J. Exp. Med. 183 (1996) 1857-1864
    • (1996) J. Exp. Med. , vol.183 , pp. 1857-1864
    • Croix, D.A.1    Ahearn, J.M.2    Rosengard, A.M.3    Han, S.4    Kelsoe, G.5    Ma, M.6    Carroll, M.C.7
  • 14
    • 0030593030 scopus 로고    scopus 로고
    • C3d of complement as a molecular adjuvant: bridging innate and acquired immunity
    • Dempsey P.W., Allison M.E., Akkaraju S., Goodnow C.C., and Fearon D.T. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271 (1996) 348-350
    • (1996) Science , vol.271 , pp. 348-350
    • Dempsey, P.W.1    Allison, M.E.2    Akkaraju, S.3    Goodnow, C.C.4    Fearon, D.T.5
  • 15
    • 0032104018 scopus 로고    scopus 로고
    • Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response
    • Fang Y., Chenguang X., Yang-Xin F., Holers M., and Molina H. Expression of complement receptors 1 and 2 on follicular dendritic cells is necessary for the generation of a strong antigen-specific IgG response. J. Immunol. 160 (1998) 5273-5279
    • (1998) J. Immunol. , vol.160 , pp. 5273-5279
    • Fang, Y.1    Chenguang, X.2    Yang-Xin, F.3    Holers, M.4    Molina, H.5
  • 16
    • 0034097043 scopus 로고    scopus 로고
    • Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
    • Fearon D.T., and Carroll M.C. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu. Rev. Immunol. 18 (2000) 393-422
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 393-422
    • Fearon, D.T.1    Carroll, M.C.2
  • 17
    • 5044252309 scopus 로고    scopus 로고
    • Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells
    • Ferguson A.R., Youd M.E., and Corley R.B. Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells. Intl. Immunol. 16 (2004) 1411-1422
    • (2004) Intl. Immunol. , vol.16 , pp. 1411-1422
    • Ferguson, A.R.1    Youd, M.E.2    Corley, R.B.3
  • 19
    • 2142718128 scopus 로고    scopus 로고
    • IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fcγ receptors
    • Getahun A., Dahlstrom J., Wernersson S., and Heyman B. IgG2a-mediated enhancement of antibody and T cell responses and its relation to inhibitory and activating Fcγ receptors. J. Immunol. 172 (2004) 5269-5276
    • (2004) J. Immunol. , vol.172 , pp. 5269-5276
    • Getahun, A.1    Dahlstrom, J.2    Wernersson, S.3    Heyman, B.4
  • 20
    • 27744568318 scopus 로고    scopus 로고
    • Genetic fusion of three tandem copies of murine C3d sequences to diptheria toxin fragment B elicits a decreased fragment B-specific antibody response
    • Gor D.O., Ding X., Li Q., and Greenspan N.S. Genetic fusion of three tandem copies of murine C3d sequences to diptheria toxin fragment B elicits a decreased fragment B-specific antibody response. Immunol. Lett. 102 (2005) 38-49
    • (2005) Immunol. Lett. , vol.102 , pp. 38-49
    • Gor, D.O.1    Ding, X.2    Li, Q.3    Greenspan, N.S.4
  • 21
    • 0021240781 scopus 로고
    • Relation of intra-splenic migration of marginal zone B cells to antigen localization on follicular dendritic cells
    • Gray D., Kumararatne D.S., Lortan J., Khan M., and MacLennan I.C.M. Relation of intra-splenic migration of marginal zone B cells to antigen localization on follicular dendritic cells. Immunology 52 (1984) 659-669
    • (1984) Immunology , vol.52 , pp. 659-669
    • Gray, D.1    Kumararatne, D.S.2    Lortan, J.3    Khan, M.4    MacLennan, I.C.M.5
  • 23
    • 0035889946 scopus 로고    scopus 로고
    • Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface
    • Guthridge J.M., Young K., Gipson M.G., Sarrias M.R., Szakonyi G., Chen X.S., Malaspina A., Donoghue E., James J.A., Lambris J.D., Moir S.A., Perkins S.J., et al. Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface. J. Immunol. 167 (2001) 5758-5766
    • (2001) J. Immunol. , vol.167 , pp. 5758-5766
    • Guthridge, J.M.1    Young, K.2    Gipson, M.G.3    Sarrias, M.R.4    Szakonyi, G.5    Chen, X.S.6    Malaspina, A.7    Donoghue, E.8    James, J.A.9    Lambris, J.D.10    Moir, S.A.11    Perkins, S.J.12
  • 24
    • 18744396051 scopus 로고    scopus 로고
    • Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses
    • Haas K.M., Hasegawa M., Steeber D.A., Poe J.C., Zabel M.D., Bock C.B., Karp D.R., Briles D.E., Weis J.H., and Tedder T.F. Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. Immunity 17 (2002) 713-723
    • (2002) Immunity , vol.17 , pp. 713-723
    • Haas, K.M.1    Hasegawa, M.2    Steeber, D.A.3    Poe, J.C.4    Zabel, M.D.5    Bock, C.B.6    Karp, D.R.7    Briles, D.E.8    Weis, J.H.9    Tedder, T.F.10
  • 26
    • 0029797256 scopus 로고    scopus 로고
    • In vitro complement-dependent binding and in vivo kinetics of pneumococcal polysaccharide TI-2 antigens in the rat spleen marginal zone and follicle
    • Harms G., Hardonk M.J., and Timens W. In vitro complement-dependent binding and in vivo kinetics of pneumococcal polysaccharide TI-2 antigens in the rat spleen marginal zone and follicle. Infect. Immun. 64 (1996) 4220-4225
    • (1996) Infect. Immun. , vol.64 , pp. 4220-4225
    • Harms, G.1    Hardonk, M.J.2    Timens, W.3
  • 27
    • 0035545679 scopus 로고    scopus 로고
    • Generation of recombinant human C3dg tetramers for the analysis of CD21 binding and function
    • Henson S.E., Smith D., Boackle S.A., Holers V.M., and Karp D.R. Generation of recombinant human C3dg tetramers for the analysis of CD21 binding and function. J. Immunol. Methods 258 (2001) 97-109
    • (2001) J. Immunol. Methods , vol.258 , pp. 97-109
    • Henson, S.E.1    Smith, D.2    Boackle, S.A.3    Holers, V.M.4    Karp, D.R.5
  • 29
    • 0034046181 scopus 로고    scopus 로고
    • Regulation of antibody responses via antibodies, complement, and Fc receptors
    • Heyman B. Regulation of antibody responses via antibodies, complement, and Fc receptors. Ann. Rev. Immunol. 18 (2000) 709-737
    • (2000) Ann. Rev. Immunol. , vol.18 , pp. 709-737
    • Heyman, B.1
  • 30
    • 0025127325 scopus 로고
    • In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody
    • Heyman B., Wiersma E.J., and Kinoshita T. In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody. J. Exp. Med. 172 (1990) 665-668
    • (1990) J. Exp. Med. , vol.172 , pp. 665-668
    • Heyman, B.1    Wiersma, E.J.2    Kinoshita, T.3
  • 31
    • 0021191226 scopus 로고
    • The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them
    • Humphrey J.H., Grennan D., and Sundaram V. The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them. Eur. J. Immunol. 14 (1984) 859-864
    • (1984) Eur. J. Immunol. , vol.14 , pp. 859-864
    • Humphrey, J.H.1    Grennan, D.2    Sundaram, V.3
  • 32
    • 0038173808 scopus 로고    scopus 로고
    • Evaluation of the compatibility of a second generation recombinant anthrax vaccine with aluminum-containing adjuvants
    • Jendrek S., Little S.F., Hem S., Mitra G., and Giardina S. Evaluation of the compatibility of a second generation recombinant anthrax vaccine with aluminum-containing adjuvants. Vaccine 21 (2003) 3011-3018
    • (2003) Vaccine , vol.21 , pp. 3011-3018
    • Jendrek, S.1    Little, S.F.2    Hem, S.3    Mitra, G.4    Giardina, S.5
  • 34
    • 0025299101 scopus 로고
    • Characterization of murine complement receptor type 2 and its immunological cross-reactivity with type 1 receptor
    • Kinoshita T., Thyphronitis G., Tsokos G.C., Finkelman F.D., Hong K., Sakai H., and Inoue K. Characterization of murine complement receptor type 2 and its immunological cross-reactivity with type 1 receptor. Int. Immunol. 2 (1990) 651-659
    • (1990) Int. Immunol. , vol.2 , pp. 651-659
    • Kinoshita, T.1    Thyphronitis, G.2    Tsokos, G.C.3    Finkelman, F.D.4    Hong, K.5    Sakai, H.6    Inoue, K.7
  • 35
    • 3142602923 scopus 로고    scopus 로고
    • CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques
    • Klinman D.M., Xie H., Little S.F., Currie D., and Ivins B.E. CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques. Vaccine 22 (2004) 2881-2886
    • (2004) Vaccine , vol.22 , pp. 2881-2886
    • Klinman, D.M.1    Xie, H.2    Little, S.F.3    Currie, D.4    Ivins, B.E.5
  • 36
    • 29144503991 scopus 로고    scopus 로고
    • Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement
    • Lee Y., Haas K.M., Gor D.O., Ding X., Karp D.R., Greenspan N.S., Poe J.C., and Tedder T.F. Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. J. Immunol. 175 (2005) 8011-8023
    • (2005) J. Immunol. , vol.175 , pp. 8011-8023
    • Lee, Y.1    Haas, K.M.2    Gor, D.O.3    Ding, X.4    Karp, D.R.5    Greenspan, N.S.6    Poe, J.C.7    Tedder, T.F.8
  • 39
    • 0345096575 scopus 로고    scopus 로고
    • Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine
    • Little S.F., Ivines B.E., Fellows P.F., Pitt M.L.M., Norris S.L.W., and Andrews G.P. Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine. Vaccine 22 (2003) 422-430
    • (2003) Vaccine , vol.22 , pp. 422-430
    • Little, S.F.1    Ivines, B.E.2    Fellows, P.F.3    Pitt, M.L.M.4    Norris, S.L.W.5    Andrews, G.P.6
  • 40
    • 0023895994 scopus 로고
    • Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin
    • Little S.F., Leppla S.H., and Cora E. Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin. Infect. Immun. 56 (1988) 1807-1813
    • (1988) Infect. Immun. , vol.56 , pp. 1807-1813
    • Little, S.F.1    Leppla, S.H.2    Cora, E.3
  • 41
    • 0029912953 scopus 로고    scopus 로고
    • Human immune response to pneumococcal polysaccharides: complement-mediated localization preferentially on CD21-positive splenic marginal zone B cells and follicular dendritic cells
    • Llopis M.J., Harms G., Hardonk M., and Timens W. Human immune response to pneumococcal polysaccharides: complement-mediated localization preferentially on CD21-positive splenic marginal zone B cells and follicular dendritic cells. J. Allergy Clin. Immunol. 97 (1996) 1015-1024
    • (1996) J. Allergy Clin. Immunol. , vol.97 , pp. 1015-1024
    • Llopis, M.J.1    Harms, G.2    Hardonk, M.3    Timens, W.4
  • 44
    • 0016165221 scopus 로고
    • Role of complement in induction of antibody production in vivo
    • Pepys M.B. Role of complement in induction of antibody production in vivo. J. Exp. Med. 140 (1974) 126-145
    • (1974) J. Exp. Med. , vol.140 , pp. 126-145
    • Pepys, M.B.1
  • 45
    • 0037220540 scopus 로고    scopus 로고
    • Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice
    • Pozdnyakova O., Guttormsen H.K., Lalani F.N., Carroll M.C., and Kasper D.L. Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice. J. Immunol. 170 (2003) 84-90
    • (2003) J. Immunol. , vol.170 , pp. 84-90
    • Pozdnyakova, O.1    Guttormsen, H.K.2    Lalani, F.N.3    Carroll, M.C.4    Kasper, D.L.5
  • 47
    • 0032211058 scopus 로고    scopus 로고
    • Characterization of C3dg binding to a recess formed between short consensus repeats 1 and 2 of complement receptor type 2 (CR2; CD21)
    • Prodinger W.M., Schwendinger M.G., Schoch J., Kochle M., Larcher C., and Dierich M.P. Characterization of C3dg binding to a recess formed between short consensus repeats 1 and 2 of complement receptor type 2 (CR2; CD21). J. Immunol. 161 (1998) 4604-4610
    • (1998) J. Immunol. , vol.161 , pp. 4604-4610
    • Prodinger, W.M.1    Schwendinger, M.G.2    Schoch, J.3    Kochle, M.4    Larcher, C.5    Dierich, M.P.6
  • 48
    • 0141703227 scopus 로고    scopus 로고
    • A dually active anthrax vaccine that confers protection against both bacilli and toxins
    • Rhie G., Roehrl M., Mourez M., Collier R.J., Mekalanos J.J., and Wang J. A dually active anthrax vaccine that confers protection against both bacilli and toxins. PNAS 100 (2003) 10925-10930
    • (2003) PNAS , vol.100 , pp. 10925-10930
    • Rhie, G.1    Roehrl, M.2    Mourez, M.3    Collier, R.J.4    Mekalanos, J.J.5    Wang, J.6
  • 50
    • 0034252626 scopus 로고    scopus 로고
    • C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge
    • Ross T.M., Xu Y., Bright R.A., and Robinson H.L. C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge. Nat. Immunol. 1 (2000) 127-131
    • (2000) Nat. Immunol. , vol.1 , pp. 127-131
    • Ross, T.M.1    Xu, Y.2    Bright, R.A.3    Robinson, H.L.4
  • 51
    • 0034924961 scopus 로고    scopus 로고
    • Enhanced avidity maturation of antibody to human immunodeficiency virus envelope: DNA vaccination with gp120-C3d fusion proteins
    • Ross T.M., Xu Y., Green T.D., Montefiori D.C., and Robinson H. Enhanced avidity maturation of antibody to human immunodeficiency virus envelope: DNA vaccination with gp120-C3d fusion proteins. AIDS Res. Human Retroviruses 17 (2001) 829-835
    • (2001) AIDS Res. Human Retroviruses , vol.17 , pp. 829-835
    • Ross, T.M.1    Xu, Y.2    Green, T.D.3    Montefiori, D.C.4    Robinson, H.5
  • 53
    • 0021245419 scopus 로고
    • Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody
    • Tedder T.F., Clement L.T., and Cooper M.D. Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. J. Immunol. 133 (1984) 678-683
    • (1984) J. Immunol. , vol.133 , pp. 678-683
    • Tedder, T.F.1    Clement, L.T.2    Cooper, M.D.3
  • 56
    • 0842347779 scopus 로고    scopus 로고
    • Fusion to C3d enhances immunogenicity of the E2 glycoprotein of type 2 bovine viral diarrhea virus
    • Wang L., Sunyer O., and Bello L.J. Fusion to C3d enhances immunogenicity of the E2 glycoprotein of type 2 bovine viral diarrhea virus. J. Virol. 78 (2004) 1616-1622
    • (2004) J. Virol. , vol.78 , pp. 1616-1622
    • Wang, L.1    Sunyer, O.2    Bello, L.J.3
  • 57
    • 4043065702 scopus 로고    scopus 로고
    • Analyses of the in vivo trafficking of stoichiometric doses of an anti-complement receptor 1/2 monoclonal antibody infused intravenously in mice
    • Whipple E.C., Shanahan R.S., Ditto A.H., Taylor R.P., and Lindorfer M.A. Analyses of the in vivo trafficking of stoichiometric doses of an anti-complement receptor 1/2 monoclonal antibody infused intravenously in mice. J. Immunol. 173 (2004) 2297-2306
    • (2004) J. Immunol. , vol.173 , pp. 2297-2306
    • Whipple, E.C.1    Shanahan, R.S.2    Ditto, A.H.3    Taylor, R.P.4    Lindorfer, M.A.5
  • 58
    • 12844272901 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine
    • Xie H., Gursel I., Ivins B.E., Singh M., O'Hagan D.T., Ulmer J.B., and Klinman D.M. CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine. Infect. Immun. 73 (2005) 828-833
    • (2005) Infect. Immun. , vol.73 , pp. 828-833
    • Xie, H.1    Gursel, I.2    Ivins, B.E.3    Singh, M.4    O'Hagan, D.T.5    Ulmer, J.B.6    Klinman, D.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.