Cytoskeletal basis of ion channel function in cardiac muscle

Future Cardiology

Volumn 2, Issue 4, 2006, Pages 467-476

  Vatta, Matteo ^a   Faulkner, Georgine ^b  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

Arrythmias; Caveolin 3; Cytoskeleton; Dystrophin; Dystrophin glycoprotein complex; Ion Channel; Potassium channels; SCN5A; Syntrophin

Indexed keywords

ACTIN; ANKYRIN; CALCIUM CHANNEL L TYPE; CYTOSKELETON PROTEIN; DYSTROPHIN; GLYCOPROTEIN; ION CHANNEL; MYOSIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNQ1; SODIUM CHANNEL; SYNTROPHIN;

ARRHYTHMOGENESIS; BECKER MUSCULAR DYSTROPHY; CARDIOMYOPATHY; CELL MEMBRANE; CHOLINERGIC SYSTEM; CLINICAL PRACTICE; CLINICAL TRIAL; CONGESTIVE CARDIOMYOPATHY; CYTOPLASM; CYTOSKELETON; DISEASE PREDISPOSITION; DUCHENNE MUSCULAR DYSTROPHY; ELECTROCARDIOGRAPHY; ELECTROSTIMULATION; GENE FUNCTION; GENE LOCATION; GENE MUTATION; HEART ARRHYTHMIA; HEART ASSIST DEVICE; HEART FAILURE; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; INTRACELLULAR TRANSPORT; MOLECULAR MECHANICS; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REVIEW; SARCOLEMMA; SYMPATHETIC TONE; TREATMENT OUTCOME;

EID: 33747742456     PISSN: 14796678     EISSN: 17448298     Source Type: Journal    
DOI: 10.2217/14796678.2.4.467     Document Type: Review

References (73)

1. Hombach V: Electrocardiogram of the failing heart. Card. Electrophysiol. Rev. 6(3), 209-214 (2002).
2. Harding JD, Piacentino VR, Gaughan JP et al.: Electrophysiological alterations after mechanical circulatory support in patients with advanced cardiac failure. Circulation 104(11), 1241-1247 (2001).
3. Iqbal I, Ventura HO, Smart FW et al.: Difficult cases in heart failure: left ventricular assist device implantation for the treatment of recurrent ventricular tachycardia in end stage heart failure. Congest. Heart Fail. 5(3), 129-130 (1999).
4. Maile S, Kunz M, Oechslin E et al.: Intractable ventricular tachycardia and bridging to heart transplantation with a non-pulsatile flow assist device in a patient with isolated left-ventricular non-compaction. J. Heart Lung Transplant. 23(1), 147-149 (2004).
5. Salzberg SP, Lachat ML, Zund G et al.: Left ventricular assist device (LVAD) enables survival during 7 h of sustained ventricular fibrillation. Eur. J. Cardiothorac. Surg. 26(2), 444-446 (2004).
6. Rose EA, Gelijns AC, Moskowitz AJ et al.: Long-term mechanical left ventricular assistance for end-stage heart failure. N. Engl. J. Med. 345(20), 1435-1443 (2001).
7. Harding JD, Piacentino V 3rd, Rothman S et al.: Prolonged repolarization after ventricular assist device support is associated with arrhythmias in humans with congestive heart failure. J. Card. Fail. 11(3), 227-232 (2005).
8. Ziv O, Dizon J, Thosani A et al.: Effects of left ventricular assist device therapy on ventricular arrhythmias. J. Am. Coll. Cardiol. 45(9), 1428-1434 (2005).
9. Kamkin A, Kiseleva I, Isenberg G: Stretch-activated currents in ventricular myocytes: amplitude and arrhythmogenic effects increase with hypertrophy. Cardiovasc. Res. 48(3), 409-420 (2000).
10. Agarkova I, Perriard JC: The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere. Trends Cell Biol. 15(9), 477-485 (2005).
11. Lange S, Himmel M, Auerbach D et al.: Dimerisation of myomesin: implications for the structure of the sarcomeric M-band. J. Mol. Biol. 345(2), 289-298 (2005).
12. Faulkner G, Pallavicini A, Formentin E et al.: ZASP: a new Z-band alternatively spliced PDZ-motif protein. J. Cell Biol. 146(2), 465-475 (1999).
13. Faulkner G, Pallavicini A, Comelli A et al.: FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle. J. Biol. Chem. 275(52), 41234-41242 (2000).
14. Zhou Q, Ruiz-Lozano P, Martone ME et al.: Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to α-actinin-2 and protein kinase C. J. Biol. Chem. 274(28), 19807-19813 (1999).
15. Klaavuniemi T, Ylanne J: Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with α-actinin-analysis of patient mutations. Exp. Cell Res. 312(8), 1299-1311 (2006).
16. Frey N, Olson EN: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. J. Biol. Chem. 277(16, 13998-14004 (2002).
17. Towbin JA, Bowles NE: The failing heart. Nature 415(6868), 227-233 (2002).
18. + channel activity. Am. J. Physiol. 261(5 Pt 1), C882-C888 (1991).
19. Undrovinas AI, Shander GS, Makielski JC: Cytoskeleton modulates gating of voltage-dependent sodium channel in heart. Am. J. Physiol. 269(1 Pt 2), H203-H214 (1995).
20. Maruoka ND, Steele DF, Au BP et al.: A-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells. FEBS Lett. 473(2), 188-194 (2000).
21. + channel protein in explanted cardiac tissue. J. Clin. Invest. 96(1), 282-292 (1995).
22. Furukawa T, Ono Y, Tsuchiya H et al.: Specific interaction of the potassium channel β-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. J. Mol. Biol. 313(4), 775-784 (2001).
23. Vatta M, Li H, Towbin JA: Molecular biology of arrhythmic syndromes. Curr. Opin. Cardiol. 15(1), 12-22 (2000).
24. Knoll R, Hoshijima M, Hoffman HM et al.: The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111(7), 943-955 (2002).
25. Vatta M, Mohapatra B, Jimenez S et al.: Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. J. Am. Cell. Cardiol. 42(11), 2014-2027 (2003).
26. Kuryshev YA, Wible BA, Gudz TI et al.: KChAP/Kvβ1.2 interactions and their effects on cardiac Kv channel expression. Am. J. Physiol. Cell Physiol. 281(1), C290-C299 (2001).
27. + channel surface expression through effects early in biosynthesis. Neuron 16(4), 843-852 (1996).
28. Peri R, Wible BA, Brown AM: Mutations in the Kv β 2 binding site for NADPH and their effects on Kv1.4. J. Mol. Chem. 276(1), 738-741 (2001).
29. Lombardi SJ, Truong A, Spence P et al.: Structure-activity relationships of the Kvβ1 inactivation domain and its putative receptor probed using peptide analogs of voltage-gated potassium channel α- and β-subunits. J. Biol. Chem. 273(46, 30092-30096 (1998).
30. Nerbonne JM, Kass RS: Molecular physiology of cardiac repolarization. Physiol. Rev. 85(4), 1205-1253 (2005).
31. Li D, Takimoto K, Levitan ES: Surface expression of Kv1 channels is governed by a C-terminal motif. J. Biol. Chem. 275(16), 11597-11602 (2000).
32. Griffith LC: Potassium channels: the importance of transport signals. Curr. Biol. 11(6), R226-R228 (2001).
33. Jiang C, Atkinson D, Towbin JA et al.: Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity. Nat. Genet. 8(2), 141-147 (1994).
34. Keating M, Dunn C, Atkinson D et al.: Consistent linkage of the long-QT syndrome to the Harvey ras-1 locus on chromosome 11. Am. J. Hum. Genet. 49(6), 1335-1339 (1991).
35. Barhanin J, Lesage F, Guillemare E et al.: K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384(6604), 78-80 (1996).
36. Sanguinetti MC, Curran ME, Zou A et al.: Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384(6604), 80-83 (1996).
37. Abbott GW, Sesti F, Splawski I et al.: MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97(2), 175-187 (1999).
38. Derst C, Karschin C, Wischmeyer E et al.: Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits. FEBS Lett. 491(3), 305-311 (2001).
39. Plaster NM, Tawil R, Tristani-Firouzi M et al.: Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell 105(4), 511-519 (2001).
40. Splawski I, Timothy KW, Sharpe LM et al.: Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 119(1), 19-31 (2004).
41. Splawski I, Timothy KW, Decher N et al.: Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proc. Natl Acad. Sci. USA 102(23), 8089-8096 (2005).
42. Mohler PJ, Schott JJ, Gramolini AO et al.: Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature 421(6923), 634-639 (2003).
43. + channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. Circ. Res. 86(4), 441-447 (2000).
44. Baroudi G, Pouliot V, Denjoy I et al.: Novel mechanism for Brugada syndrome: defective surface localization of an SCN5A mutant (R1432G). Circ. Res. 88(2), E78-E83 (2001).
45. McNair WP, Ku L, Taylor MR et al.: SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation 110(15), 2163-2167 (2004).
46. Olson TM, Michels VV, Ballew JD et al.: Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA 293(4), 447-454 (2005).
47. Blake DJ, Weir A, Newey SE et al.: Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol. Rev. 82(2), 291-329 (2002).
48. Rybakova IN, Humston JL, Sonnemann KJ Ervasti JM: Dystrophin and utrophin bind actin through distinct modes of contact. J. Biol. Chem. (2006).
49. Hoffman EP, Brown RH, Jr, Kunkel LM: Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 51(6), 919-928 (1987).
50. Towbin JA, Hejtmancik JF, Brink P et al.: X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. Circulation 87(6), 1854-1865 (1993).
51. Brown SC, Lucy JA: Dystrophin as a mechanochemical transducer in skeletal muscle. Bioessays 15, 413-419 (1993).
52. Ribaux P, Bleicher F, Couble ML et al.: Voltage-gated sodium channel (SkM1) content in dystrophin-deficient muscle. Pflugers Arch. 441(6), 746-755 (2001).
53. Ahn AH, Yoshida M, Anderson MS et al.: Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24. Proc. Natl Acad. Sci. USA 91(10), 4446-4450 (1994).
54. Adams ME, Dwyer TM, Dowler LL et al.: Mouse α1- and β2-syntrophin gene structure, chromosome localization, and homology with a discs large domain. J. Biol. Chem. 270(43), 25859-25865 (1995).
55. Piluso G, Mirabella M, Ricci E et al.: H1- and γ2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. J. Biol. Chem. 275(21), 15851-15860 (2000).
56. Ahn AH, Kunkel LM: Syntrophin binds to an alternatively spliced exon of dystrophin. J. Cell Biol. 128(3), 363-371 (1995).
57. Kachinsky AM, Froehner SC, Milgram SL: A PDZ-containing scaffold related to the dystrophin complex at the basolateral membrane of epithelial cells. J. Cell Biol. 145(2), 391-402 (1999).
58. Chockalingam PS, Gee SH, Jarrett HW: Pleckstrin homology domain 1 of mouse α 1-syntrophin binds phosphatidylinositol 4,5-bisphosphate. Biochemistry 38(17), 5596-5602 (1999).
59. Brenman JE, Chao DS, Gee SH et al.: Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains. Cell 84(5), 757-767 (1996).
60. Frigeri A, Nicchia GP, Verbavatz JM et al.: Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle. J. Clin. Invest. 102(4), 695-703 (1998).
61. Hasegawa M, Cuenda A, Spillantini MG et al.: Stress-activated protein kinase-3 interacts with the PDZ domain of α1-syntrophin. A mechanism for specific substrate recognition. J. Biol. Chem. 274(18), 12626-12631 (1999).
62. Gee SH, Madhavan R, Levinson SR et al.: Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. J. Neurosci. 18(1), 128-137 (1998).
63. Adams ME, Mueller HA, Froehner SC: In vivo requirement of the α-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4. J. Cell Biol. 155(1), 113-122 (2001).
64. Peters MF, Adams ME, Froehner SC: Differential association of syntrophin pairs with the dystrophin complex. J. Cell Biol. 138(1), 81-93 (1997).
65. Peters MF, Kramarcy NR, Sealock R et al.: X 2-Syntrophin: localization at the neuromuscular junction in skeletal muscle. Neuroreport 5(13), 1577-1580 (1994).
66. Kramarcy NR, Sealock R: Syntrophin isoforms at the neuromuscular junction: developmental time course and differential localization. Mol. Cell Neurosci. 15(3), 262-274 (2000).
67. Ou Y, Strege P, Miller SM et al.: Syntrophin γ2 regulates SCN5A gating by a PDZ domain-mediated interaction. J. Biol. Chem. 278(3), 1915-1923 (2003).
68. Feron O, Kelly RA: Gaining respectability: membrane-delimited, caveolar-restricted activation of ion channels. Circ. Res. 90(4), 369-370 (2002).
69. Parton RG, Way M, Zorzi N et al.: Caveolin-3 associates with developing T-tubules during muscle differentiation. J. Cell Biol. 136(1), 137-154 (1997).
70. Bossuyt J, Taylor BE, James-Kracke M et al.: Evidence for cardiac sodium-calcium exchanger association with caveolin-3. FEBS Lett. 511(1-3), 113-117 (2002).
71. Venema VJ, Ju H, Zou R et al.: Interaction of neuronal nitric-oxide synthase with caveolin-3 in skeletal muscle. Identification of a novel caveolin scaffolding/inhibitory domain. J. Mol. Chem. 272(45), 28187-28190 (1997).
72. Campbell KP, Kahl SD: Association of dystrophin and an integral membrane glycoprotein. Nature 338(6212), 259-262 (1989).
73. Durbeej M, Campbell KP: Muscular dystrophies involving the dystrophin-glycoprotein complex: an overview of current mouse models. Curr. Opin. Gen. Dev. 12(3), 349-361 (2002).